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Pan Zhengying
College of Chemical Biology and Biotechnology
Peking University
Guangdong
Language: English, Chinese
Tumor
Drug Chemistry
Kinase
Signal Transduction
Synthetic Methodology
Drug Discovery
Cancer
Biochemistry
Pharmacology
Molecular Biology
Areas of Focus
- Tumor-targeted drug chemistry
- Kinase omics - precision tools for signal transduction research
- Development of synthetic methodology
Work Experience
- 2009-present - Peking University Shenzhen Graduate School, Shenzhen - Doctoral Supervisor, Distinguished Researcher
- 2008-2009 - OPTI Medical Systems, IDEXX Laboratories, Roswell - Research Scientist
- 2006-2007 - AtheroGenics, Alpharetta - Senior Scientist
- 2002-2006 - Celera Genomics, South San Francisco - Senior Scientist
- 2000-2002 - Stanford University, Stanford - Postdoctoral Researcher
Academic Background & Achievements
- 1989-1994 Bachelor: Peking University, Beijing
- 1994-1999 PhD: Columbia University, New York
- 1994 Outstanding Graduate Award: Peking University, Beijing
Publications
- Irreversible dual inhibitory mode: the novel Btk inhibitor PLS-123 demonstrates promising anti-tumor activity in human B-cell lymphoma., Ding, N.; Li, X.; Shi, Y.; Ping, L.; Wu, L.; Fu, K.; Feng, L.; Zheng, X.; Song, Y.; Pan, Z.; Zhu, J., 2015
- A general approach for the development of fluorogenic probes suitable for no-wash imaging of kinases in live cells., Zhang Q, Liu H, Pan Z., 2014
- Synthesis of Highly Substituted Imidazolidine-2,4-dione (Hydantoin) through Tf2O-Mediated Dual Activation of Boc-Protected Dipeptidyl Compounds., Liu H, Yang Z, Pan Z., 2014
- Site-selective Protein Immobilization by Covalent Modification of GST Fusion Proteins., Zhou Y, Guo T, Tang G, Wu H, Wong N-K, Pan Z., 2014
- Discovery of a Series of 2,5-Diaminopyrimidine Covalent Irreversible Inhibitors of Bruton’s Tyrosine Kinase with in Vivo Antitumor Activity., Li X, Zuo Y, Tang G, Wang Y, Zhou Y, Wang X, Guo T, Xia M, Ding N, Pan Z., 2014
- Discovery of selective 2,4-diaminopyrimidine-based photoaffinity probes for glyoxalase I., Zhou Y, Guo T, Li X, Dong Y, Galatsis P, Johnson D S, Pan Z., 2014
- Reductant-directed formation of PS-PAMAM-supported gold nanoparticles for use as highly active and recyclable catalysts for the aerobic oxidation of alcohols and the homocoupling of phenylboronic acids., Zheng J, Lin S, Zhu X, Jiang B, Yang Z, Pan Z., 2012
- The Bruton Tyrosine Kinase Inhibitor PCI-32765 Blocks B-cell Activation and Is Efficacious in Models of Autoimmune Disease and B-cell Malignancy., Honigberg, L.A.; Smith, A.M.; Sirisawad, M.; Verner, E.; Loury, D.; Chang, B.; Li, S.; Pan, Z.; Thamm, D.H.; Miller, R.A.; Buggy, J.J., 2010
- Discovery of Selective Irreversible Inhibitors for Bruton’s Tyrosine Kinase., Pan, Z.; Scheerens, H.; Li, S.-J.; Schultz, B. E.; Sprengeler, P. A.; Burrill, L. C.; Mendonca, R. V.; Sweeney, M. D.; Scott, K. C. K.; Grothaus, P. G.; Jeffery, D. A.; Spoerke, J. M.; Honigberg, L. A.; Peter R. Young, Dalrymple, S. A. and Palmer, J. T., 2007
- Development of Activity-based Probes for Trypsin-family Serine Proteases., Pan, Z.; Jeffery, D. A.; Chehade, K.; Beltman, J.; Clark, J. M.; Grothaus, P. G.; Bogyo, M. and Baruch, A., 2006
Awards
- 2013 WuXi AppTec Life Science and Chemistry Scholar Award: Shanghai
- 2005 Celera DNA Award: Celera Genomics, South San Francisco, CA
