Professor | Cao Can | Asia Growth Partners

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Name	Cao Can
Contact Information	caocan23@ustc.edu.cn
Language ability	English, Chinese
Province	Anhui

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Name

Cao Can

Contact Information

caocan23@ustc.edu.cn

Language ability

English, Chinese

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Life Sciences
Academic Background & Achievements	2011 - Bachelor's Degree: China Agricultural University 2017 - Doctorate: University of Chinese Academy of Sciences, Institute of Biophysics
Work Experience	2018-10 to 2023-04 - University of North Carolina at Chapel Hill - Postdoctoral Research 2023-04 to Present - University of Science and Technology of China - Life Sciences and Medicine Department

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Life Sciences

Academic Background & Achievements

2011 - Bachelor's Degree: China Agricultural University
2017 - Doctorate: University of Chinese Academy of Sciences, Institute of Biophysics

Work Experience

2018-10 to 2023-04 - University of North Carolina at Chapel Hill - Postdoctoral Research
2023-04 to Present - University of Science and Technology of China - Life Sciences and Medicine Department

Areas of Focus	Structural pharmacology of immune and neuropsychiatric GPCRs Drug discovery
Publications	Novel agonists reveal recognition motifs for the MRGPRD GPCR, Chunyu Wang, Yongfeng Liu, Marion Lanier, Adam Yeager, Isha Singh, Ryan H. Gumpper, Brian E. Krumm, Chelsea DeLeon, Shicheng Zhang, Marcus Boehm, Richard Pittner, Alain Baron, Lisa Dvorak, Corinne Bacon, Brian K. Shoichet, Esther Martinborough, Jonathan F. Fay, Can Cao, Bryan L. Roth, 2024 Structure, function and pharmacology of human itch GPCRs, Cao, C., Kang, H. J., Singh, I., Chen, H., Zhang, C., Ye, W., Hayes, B. W., Liu, J., Gumpper, R. H., Bender, B. J., Slocum, S. T., Krumm, B. E., Lansu, K., McCorvy, J. D., Kroeze, W. K., English, J. G., DiBerto, J. F., Olsen, R. H. J., Huang, X. P., Zhang, S., Liu, Y., Kim, K., Karpiak, J., Jan, L. Y., Abraham, S. N., Jin, J., Shoichet, B. K., Fay, J. F., Roth, B. L., 2021 MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model, Chien, D. C., Limjunyawong, N., Cao, C., Meixiong, J., Peng, Q., Ho, C. Y., Fay, J. F., Roth, B. L., Dong, X., 2024 The structure, function and pharmacology of MRGPRs, Cao, C., Roth, B. L., 2023 Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD, Cao, C., Barros-Alvarez, X., Zhang, S., Kim, K., Damgen, M. A., Panova, O., Suomivuori, C. M., Fay, J. F., Zhong, X., Krumm, B. E., Gumpper, R. H., Seven, A. B., Robertson, M. J., Krogan, N. J., Huttenhain, R., Nichols, D. E., Dror, R. O., Skiniotis, G., Roth, B. L., 2022 Ligand recognition and allosteric modulation of the human MRGPRX1 receptor, Liu, Y., Cao, C., Huang, X. P., Gumpper, R.H., Rachman, M.M., Shih, S.L., Krumm, B.E., Zhang, S., Shoichet, B.K., Fay, J. F., Roth, B. L., 2022 Structural basis for signal recognition and transduction by platelet-activating-factor receptor, Cao, C., Tan, Q., Xu, C., He, L., Yang, L., Zhou, Y., Zhou, Y., Qiao, A., Lu, M., Yi, C., Han, G. W., Wang, X., Li, X., Yang, H., Rao, Z., Jiang, H., Zhao, Y., Liu, J., Stevens, R. C., Zhao, Q., Zhang, X. C., Wu, B., 2018 Peptide recognition, signaling and modulation of class B G protein-coupled receptors, Cao, C., Zhang, H., Yang, Z., Wu, B., 2018 Cryo-electron microscopy structure of human ABCB6 transporter, Wang, C., Cao, C., Wang, N., Wang, X., Wang, X., Zhang, X. C., 2020 Extending the Structural View of Class B GPCRs, de Graaf, C., Song, G., Cao, C., Zhao, Q., Wang, M. W., Wu, B., Stevens, R. C., 2017 Bitter taste receptor activation by cholesterol and an intracellular tastant, Kim, Y., Gumpper, R. H., Liu, Y., Kocak, D. D., Xiong, Y., Cao, C., Deng, Z., Krumm, B. E., Jain, M. K., Zhang, S., Jin, J., Roth, B. L., 2024 Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870, Zhou, Y., Cao, C., He, L., Wang, X., Zhang, X. C., 2019 Molecular basis for selective activation of DREADD-based chemogenetics, Zhang, S., Gumpper, R. H., Huang, X. P., Liu, Y., Krumm, B. E., Cao, C., Fay, J. F., Roth, B. L., 2022 Inactive and active state structures template selective tools for the human 5-HT5A receptor, Zhang, S., Chen, H., Zhang, C., Yang, Y., Popov, P., Liu, J., Krumm, B. E., Cao, C., Kim, K., Xiong, Y., Katritch, V., Shoichet, B. K., Jin, J., Fay, J. F., Roth, B. L., 2022 Proton transfer during class-A GPCR activation: do the CWxP motif and the membrane potential act in concert?, Zhang, X. C., Zhou, Y., Cao, C., 2018 Structure of the glucagon receptor in complex with a glucagon analogue, Zhang, H., Qiao, A., Yang, L., Van Eps, N., Frederiksen, K. S., Yang, D., Dai, A., Cai, X., Zhang, H., Yi, C., Cao, C., He, L., Yang, H., Lau, J., Ernst, O. P., Hanson, M. A., Stevens, R. C., Wang, M. W., Reedtz-Runge, S., Jiang, H., Zhao, Q., Wu, B., 2018 Proton transfer-mediated GPCR activation, Zhang, X. C., Zhou, Y., Cao, C., 2015 Thermodynamics of GPCR activation, Zhang, X. C., Zhou, Y., Cao, C., 2015 GPCR activation: protonation and membrane potential, Zhang, X. C., Sun, K., Zhang, L., Li, X., Cao, C., 2013

Areas of Focus

Structural pharmacology of immune and neuropsychiatric GPCRs
Drug discovery

Publications

Novel agonists reveal recognition motifs for the MRGPRD GPCR, Chunyu Wang, Yongfeng Liu, Marion Lanier, Adam Yeager, Isha Singh, Ryan H. Gumpper, Brian E. Krumm, Chelsea DeLeon, Shicheng Zhang, Marcus Boehm, Richard Pittner, Alain Baron, Lisa Dvorak, Corinne Bacon, Brian K. Shoichet, Esther Martinborough, Jonathan F. Fay, Can Cao, Bryan L. Roth, 2024
Structure, function and pharmacology of human itch GPCRs, Cao, C., Kang, H. J., Singh, I., Chen, H., Zhang, C., Ye, W., Hayes, B. W., Liu, J., Gumpper, R. H., Bender, B. J., Slocum, S. T., Krumm, B. E., Lansu, K., McCorvy, J. D., Kroeze, W. K., English, J. G., DiBerto, J. F., Olsen, R. H. J., Huang, X. P., Zhang, S., Liu, Y., Kim, K., Karpiak, J., Jan, L. Y., Abraham, S. N., Jin, J., Shoichet, B. K., Fay, J. F., Roth, B. L., 2021
MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model, Chien, D. C., Limjunyawong, N., Cao, C., Meixiong, J., Peng, Q., Ho, C. Y., Fay, J. F., Roth, B. L., Dong, X., 2024
The structure, function and pharmacology of MRGPRs, Cao, C., Roth, B. L., 2023
Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD, Cao, C., Barros-Alvarez, X., Zhang, S., Kim, K., Damgen, M. A., Panova, O., Suomivuori, C. M., Fay, J. F., Zhong, X., Krumm, B. E., Gumpper, R. H., Seven, A. B., Robertson, M. J., Krogan, N. J., Huttenhain, R., Nichols, D. E., Dror, R. O., Skiniotis, G., Roth, B. L., 2022
Ligand recognition and allosteric modulation of the human MRGPRX1 receptor, Liu, Y., Cao, C., Huang, X. P., Gumpper, R.H., Rachman, M.M., Shih, S.L., Krumm, B.E., Zhang, S., Shoichet, B.K., Fay, J. F., Roth, B. L., 2022
Structural basis for signal recognition and transduction by platelet-activating-factor receptor, Cao, C., Tan, Q., Xu, C., He, L., Yang, L., Zhou, Y., Zhou, Y., Qiao, A., Lu, M., Yi, C., Han, G. W., Wang, X., Li, X., Yang, H., Rao, Z., Jiang, H., Zhao, Y., Liu, J., Stevens, R. C., Zhao, Q., Zhang, X. C., Wu, B., 2018
Peptide recognition, signaling and modulation of class B G protein-coupled receptors, Cao, C., Zhang, H., Yang, Z., Wu, B., 2018
Cryo-electron microscopy structure of human ABCB6 transporter, Wang, C., Cao, C., Wang, N., Wang, X., Wang, X., Zhang, X. C., 2020
Extending the Structural View of Class B GPCRs, de Graaf, C., Song, G., Cao, C., Zhao, Q., Wang, M. W., Wu, B., Stevens, R. C., 2017
Bitter taste receptor activation by cholesterol and an intracellular tastant, Kim, Y., Gumpper, R. H., Liu, Y., Kocak, D. D., Xiong, Y., Cao, C., Deng, Z., Krumm, B. E., Jain, M. K., Zhang, S., Jin, J., Roth, B. L., 2024
Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870, Zhou, Y., Cao, C., He, L., Wang, X., Zhang, X. C., 2019
Molecular basis for selective activation of DREADD-based chemogenetics, Zhang, S., Gumpper, R. H., Huang, X. P., Liu, Y., Krumm, B. E., Cao, C., Fay, J. F., Roth, B. L., 2022
Inactive and active state structures template selective tools for the human 5-HT5A receptor, Zhang, S., Chen, H., Zhang, C., Yang, Y., Popov, P., Liu, J., Krumm, B. E., Cao, C., Kim, K., Xiong, Y., Katritch, V., Shoichet, B. K., Jin, J., Fay, J. F., Roth, B. L., 2022
Proton transfer during class-A GPCR activation: do the CWxP motif and the membrane potential act in concert?, Zhang, X. C., Zhou, Y., Cao, C., 2018
Structure of the glucagon receptor in complex with a glucagon analogue, Zhang, H., Qiao, A., Yang, L., Van Eps, N., Frederiksen, K. S., Yang, D., Dai, A., Cai, X., Zhang, H., Yi, C., Cao, C., He, L., Yang, H., Lau, J., Ernst, O. P., Hanson, M. A., Stevens, R. C., Wang, M. W., Reedtz-Runge, S., Jiang, H., Zhao, Q., Wu, B., 2018
Proton transfer-mediated GPCR activation, Zhang, X. C., Zhou, Y., Cao, C., 2015
Thermodynamics of GPCR activation, Zhang, X. C., Zhou, Y., Cao, C., 2015
GPCR activation: protonation and membrane potential, Zhang, X. C., Sun, K., Zhang, L., Li, X., Cao, C., 2013

Gpcr Immune Neuropsychiatric Structural Pharmacology Drug Discovery Signal Transduction Pharmacological Analysis Disease Treatment Artificial Intelligence Animal Experiments

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