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Chen Yuxing
Life Science
University of Science and Technology of China
Anhui
Language: English, Chinese, French
Membrane Transport Proteins
Human Diseases
Cholestasis
Liver Cirrhosis
Bile Acid Transporters
Cardiovascular Diseases
Cholesterol Transporters
Alzheimer'S Disease
Lipid Transporters
Structural Biology
Areas of Focus
- Research on the structure and function of membrane transport proteins related to major human diseases
Work Experience
- 2003-2004: Postdoctoral Researcher at the French National Research Center
- 2004: Professor and Doctoral Supervisor at Tongji University, Institute of Protein Research
- 2007-present: Professor and Doctoral Supervisor at University of Science and Technology of China
Academic Background & Achievements
- 2000-2003: PhD at Université Paris-Sud, France
- 2006: Awarded 'New Century Excellent Talents' by the Ministry of Education
- 2006: Awarded 'Pujiang Talent' by Shanghai
Publications
- Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain, Mao YX, Chen ZP, Wang L, Wang J, Zhou CZ, Hou WT, Chen Y, 2024
- Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket, Wang J, Li X, Wang FF, Cheng MT, Mao YX, Fang SC, Wang L, Zhou CZ, Hou WT, Chen Y, 2023
- Structural insights into human ABCC4-mediated transport of platelet agonist and antagonist, Chen Y, Wang L, Hou WT, Zha ZH, Xu K, Zhou CZ, Li Q, Chen YX, 2023
- Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1, Chen ZP, Xu D, Wang L, Mao YX, Li Y, Cheng MT, Zhou CZ, Hou WT, Chen Y, 2022
- Structures of human bile acid exporter ABCB11 reveal a transport mechanism facilitated by two tandem substrate-binding pockets, Wang L, Hou WT, Wang J, Xu D, Guo C, Sun LF, Ruan K, Zhou CZ, Chen Y, 2022
- Structure and Transport Mechanism of the Human Cholesterol Transporter ABCG1, Xu D, Li YY, Yang FR, Sun CR, Pan JH, Wang L, Chen ZP, Fang SC, Yao XB, Hou WT, Zhou CZ, Chen Y, 2022
- Cryo-EM structure of human bile salts exporter ABCB11, Wang L, Hou WT, Chen L, Jiang YL, Xu D, Sun LF, Zhou CZ, Chen Y, 2020
- Cryo-EM structure of human lysosomal cobalamin exporter ABCD4, Xu D, Feng Z, Hou WT, Jiang YL, Wang L, Sun LF, Zhou CZ, Chen Y, 2019
- Structure of a MacAB-like efflux pump from Streptococcus pneumoniae, Yang HB, Hou WT, Cheng MT, Jiang YL, Chen Y, Zhou CZ, 2018
Awards
- 2006: 'New Century Excellent Talents' by the Ministry of Education
- 2006: 'Pujiang Talent' by Shanghai
