Professor | Yigong Shi | Asia Growth Partners

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Name	Yigong Shi
Contact Information	shi-lab@mail.tsinghua.edu.cn
Language ability	English, Chinese
Province	Beijing

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Name

Yigong Shi

Contact Information

shi-lab@mail.tsinghua.edu.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Tsinghua University
Faculty	Life Sciences
Academic Background & Achievements	1985-1989 Bachelor of Biological Sciences and Technology: Tsinghua University 1990-1995 PhD in Molecular Biophysics: Johns Hopkins University School of Medicine Member of the Chinese Academy of Sciences Foreign Associate of the US National Academy of Sciences Foreign Honorary Member of the American Academy of Arts and Sciences
Work Experience	1995 Postdoctoral Fellow: Johns Hopkins University School of Medicine 1996-1997 Postdoctoral Fellow: Sloan-Kettering Cancer Center, New York 1998-2001 Assistant Professor: Department of Molecular Biology, Princeton University 2001-2003 Associate Professor (Tenured): Department of Molecular Biology, Princeton University 2003-2007 Professor (Tenured): Department of Molecular Biology, Princeton University 2007-2008 Warner-Lambert/Parke-Davis Professor: Department of Molecular Biology, Princeton University 2008-present Professor and Doctoral Supervisor: School of Life Sciences, Tsinghua University

University/Lab Affiliation and Title

Tsinghua University

Faculty

Life Sciences

Academic Background & Achievements

1985-1989 Bachelor of Biological Sciences and Technology: Tsinghua University
1990-1995 PhD in Molecular Biophysics: Johns Hopkins University School of Medicine
Member of the Chinese Academy of Sciences
Foreign Associate of the US National Academy of Sciences
Foreign Honorary Member of the American Academy of Arts and Sciences

Work Experience

1995 Postdoctoral Fellow: Johns Hopkins University School of Medicine
1996-1997 Postdoctoral Fellow: Sloan-Kettering Cancer Center, New York
1998-2001 Assistant Professor: Department of Molecular Biology, Princeton University
2001-2003 Associate Professor (Tenured): Department of Molecular Biology, Princeton University
2003-2007 Professor (Tenured): Department of Molecular Biology, Princeton University
2007-2008 Warner-Lambert/Parke-Davis Professor: Department of Molecular Biology, Princeton University
2008-present Professor and Doctoral Supervisor: School of Life Sciences, Tsinghua University

Areas of Focus	Structural biology, biochemistry, and biophysics of RNA splicing and apoptosis Molecular mechanisms of Alzheimer's disease mediated by γ-secretase
Publications	Structural basis of γ-secretase inhibition and modulation by small molecule drugs, Guanghui Yang, Rui Zhou, Xuefei Guo, Chuangye Yan, Jianlin Lei, Yigong Shi, 2021 Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis, Gaoxingyu Huang, Yanqing Zhang, Xuechen Zhu, Chao Zeng, Qifan Wang, Qiang Zhou, Qinghua Tao, Minhao Liu, Jianlin Lei, Chuangye Yan, Yigong Shi, 2020 Recognition of the amyloid precursor protein by human γ-secretase, Rui Zhou, Guanghui Yang, Xuefei Guo, Qiang Zhou, Jianlin Lei, Yigong Shi, 2019 Structural basis of Notch recognition by human γ-secretase, Guanghui Yang, Rui Zhou, Qiang Zhou, Xuefei Guo, Chuangye Yan, Meng Ke, Jianlin Lei, Yigong Shi, 2019 Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activation, Rui Bai, Ruixue Wan, Chuangye Yan, Jianlin Lei, Yigong Shi, 2018 Structure of a human catalytic step I spliceosome, Xiechao Zhan, Chuangye Yan, Xiaofeng Zhang, Jianlin Lei, Yigong Shi, 2018 An atomic structure of the human spliceosome, Xiaofeng Zhang, Chuangye Yan, Jing Hang, Lorenzo I. Finci, Jianlin Lei, Yigong Shi, 2017 Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae, Rui Bai, Chuangye Yan, Ruixue Wan, Jianlin Lei, Yigong Shi, 2017 Structure of a yeast catalytically activated spliceosome at 3.5 Å resolution, Chuangye Yan, Ruixue Wan, Rui Bai, Gaoxingyu Huang, Yigong Shi, 2016 Structure of a yeast catalytic step I spliceosome at 3.4 Å resolution, Ruixue Wan, Chuangye Yan, Rui Bai, Gaoxingyu Huang, Yigong Shi, 2016 Structure of a yeast spliceosome at 3.6-angstrom resolution, Chuangye Yan, Jing Hang, Ruixue Wan, Min Huang, Catherine C. L. Wong, Yigong Shi, 2015 Structural basis of pre-mRNA splicing, Jing Hang, Ruixue Wan, Chuangye Yan, Yigong Shi, 2015 Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1, Mengying Zhou, Yini Li, Qi Hu, Xiaochen Bai, Weijiao Huang, Chuangye Yan, Sjors H. W. Scheres, Yigong Shi, 2015 Three-dimensional structure of human γ-secretase, Peilong Lu, Xiao-chen Bai, Dan Ma, Tian Xie, Chuangye Yan, Linfeng Sun, Guanghui Yang, Yanyu Zhao, Rui Zhou, Sjors H. W. Scheres, Yigong Shi, 2014 Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4, Shiqian Qi, Yuxuan Pang, Qi Hu, Qun Liu, Hua Li, Yulian Zhou, Tianxi He, Qionglin Liang, Yexing Liu, Xiaoqiu Yuan, Guoan Luo, Huilin Li, Jiawei Wang, Nieng Yan, Yigong Shi, 2010

Areas of Focus

Structural biology, biochemistry, and biophysics of RNA splicing and apoptosis
Molecular mechanisms of Alzheimer's disease mediated by γ-secretase

Publications

Structural basis of γ-secretase inhibition and modulation by small molecule drugs, Guanghui Yang, Rui Zhou, Xuefei Guo, Chuangye Yan, Jianlin Lei, Yigong Shi, 2021
Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis, Gaoxingyu Huang, Yanqing Zhang, Xuechen Zhu, Chao Zeng, Qifan Wang, Qiang Zhou, Qinghua Tao, Minhao Liu, Jianlin Lei, Chuangye Yan, Yigong Shi, 2020
Recognition of the amyloid precursor protein by human γ-secretase, Rui Zhou, Guanghui Yang, Xuefei Guo, Qiang Zhou, Jianlin Lei, Yigong Shi, 2019
Structural basis of Notch recognition by human γ-secretase, Guanghui Yang, Rui Zhou, Qiang Zhou, Xuefei Guo, Chuangye Yan, Meng Ke, Jianlin Lei, Yigong Shi, 2019
Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activation, Rui Bai, Ruixue Wan, Chuangye Yan, Jianlin Lei, Yigong Shi, 2018
Structure of a human catalytic step I spliceosome, Xiechao Zhan, Chuangye Yan, Xiaofeng Zhang, Jianlin Lei, Yigong Shi, 2018
An atomic structure of the human spliceosome, Xiaofeng Zhang, Chuangye Yan, Jing Hang, Lorenzo I. Finci, Jianlin Lei, Yigong Shi, 2017
Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae, Rui Bai, Chuangye Yan, Ruixue Wan, Jianlin Lei, Yigong Shi, 2017
Structure of a yeast catalytically activated spliceosome at 3.5 Å resolution, Chuangye Yan, Ruixue Wan, Rui Bai, Gaoxingyu Huang, Yigong Shi, 2016
Structure of a yeast catalytic step I spliceosome at 3.4 Å resolution, Ruixue Wan, Chuangye Yan, Rui Bai, Gaoxingyu Huang, Yigong Shi, 2016
Structure of a yeast spliceosome at 3.6-angstrom resolution, Chuangye Yan, Jing Hang, Ruixue Wan, Min Huang, Catherine C. L. Wong, Yigong Shi, 2015
Structural basis of pre-mRNA splicing, Jing Hang, Ruixue Wan, Chuangye Yan, Yigong Shi, 2015
Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1, Mengying Zhou, Yini Li, Qi Hu, Xiaochen Bai, Weijiao Huang, Chuangye Yan, Sjors H. W. Scheres, Yigong Shi, 2015
Three-dimensional structure of human γ-secretase, Peilong Lu, Xiao-chen Bai, Dan Ma, Tian Xie, Chuangye Yan, Linfeng Sun, Guanghui Yang, Yanyu Zhao, Rui Zhou, Sjors H. W. Scheres, Yigong Shi, 2014
Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4, Shiqian Qi, Yuxuan Pang, Qi Hu, Qun Liu, Hua Li, Yulian Zhou, Tianxi He, Qionglin Liang, Yexing Liu, Xiaoqiu Yuan, Guoan Luo, Huilin Li, Jiawei Wang, Nieng Yan, Yigong Shi, 2010

Structural Biology Biochemistry Biophysics Rna Splicing Apoptosis Molecular Machines Γ-Secretase Alzheimer'S Disease Cellular Mechanisms Protein Structures

Yigong Shi - Tsinghua University

Wei Hong - University of Chinese Academy of Sciences

Minglin Lang - University of Chinese Academy of Sciences

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