1996 - Bachelor's Degree: University of Science and Technology of China
1999 - Master's Degree: University of Science and Technology of China
2004 - PhD: University of Wisconsin, Cancer Research Institute
Achievements: Published in Nature and Science, discovered siRNA pathways and mechanisms
2005-2010 - Postdoctoral Researcher: University of Wisconsin, Department of Genetics
2010-present - Researcher: School of Life Sciences
Research
Regulation of RNA expression and processing in eukaryotic cells Mechanisms of transcriptional regulation in eukaryotes Expression and regulation of non-coding RNA Genetics and development of model organisms New technologies and methods for gene editing and chromosome manipulation
Nucleolar stress induces nucleolar stress body formation via the NOSR-1/NUMR-1 axis in Caenorhabditis elegans, Minjie Hong, Xiaotian Zhou, Chenming Zeng, Demin Xu, Ting Xu, Shimiao Liao, Ke Wang, Chengming Zhu, Ge Shan, Xinya Huang, Xiangyang Chen, Xuezhu Feng & Shouhong Guang, 2024
Germ granule compartments coordinate specialized small RNA production, Xiangyang Chen, Ke Wang, Farees Ud Din Mufti, Demin Xu, Chengming Zhu, Xinya Huang, Chenming Zeng, Qile Jin, Xiaona Huang, Yong-hong Yan, Meng-qiu Dong, Xuezhu Feng, Yunyu Shi, Scott Kennedy & Shouhong Guang, 2024
The absence of the ribosomal protein Rpl2702 elicits the MAPK-mTOR signaling to modulate mitochondrial morphology and functions, Ling Liu, Yifan Wu, Ke Liu, Mengdan Zhu, Shouhong Guang, Fengsong Wang, Xing Liu, Xuebiao Yao, Jiajia He, Chuanhai Fu, 2024
Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin, Wei I Jiang, Henry De Belly, Bingying Wang, Andrew Wong, Minseo Kim, Fiona Oh, Jason DeGeorge, Xinya Huang, Shouhong Guang, Orion D Weiner, Dengke K Ma, 2024
xQTLbiolinks: a comprehensive and scalable tool for integrative analysis of molecular QTLs, Ruofan Ding, Xudong Zou, Yangmei Qin, Lihai Gong, Hui Chen, Xuelian Ma, Shouhong Guang, Chen Yu, Gao Wang, Lei Li, 2023
Acquired stress resilience through bacteria-to-nematode interdomain horizontal gene transfer, Pandey T, Kalluraya CA, Wang B, Xu T, Huang X, Shouhong Guang, Daugherty MD, Ma DK, 2023
rRNA intermediates coordinate the formation of nucleolar vacuoles in C. elegans, Demin Xu, Xiangyang Chen, Yan Kuang, Minjie Hong, Ting Xu, Ke Wang, Xinya Huang, Chuanhai Fu, Ke Ruan, Chengming Zhu, Xuezhu Feng and Shouhong Guang, 2023
Systematic characterization of chromodomain proteins reveals an H3K9me1/2 reader regulating aging in C. elegans, Xinhao Hou, Mingjing Xu, Chengming Zhu, Jianing Gao, Meili Li, Xiangyang Chen, Cheng Sun, Björn Nashan, Jianye Zang, Ying Zhou, Shouhong Guang, and Xuezhu Feng, 2022
A ZTF-7/RPS-2 complex mediates the cold-warm response in C. elegans, Ting Xu, Shimiao Liao, Meng Huang, Chengming Zhu, Xiaona Huang, Qile Jin, Demin Xu, Chuanhai Fu, Xiangyang Chen, Xuezhu Feng and Shouhong Guang, 2023
H3K9me1/2 methylation limits the lifespan of daf-2 mutants in C. elegans, Meng Huang, Minjie Hong, Chengming Zhu, Di Chen, Xiangyang Chen, Shouhong Guang, and Xuezhu Feng, 2022
ipaQTL-atlas: an atlas of intronic polyadenylation quantitative trait loci across human tissues, Xuelian Ma, Shumin Cheng, Ruofan Ding, Zhaozhao Zhao, XuDong Zou, Shouhong Guang, Qixuan Wang, Huan Jing, Chen Yu, Ting Ni, Lei Li, 2022
The SNAPc complex mediates starvation-induced trans-splicing in C. elegans, Xinhao Hou, Chengming Zhu, Mingjing Xu, Xiangyang Chen, Cheng Sun, Björn Nashana, Shouhong Guang, and Xuezhu Feng, 2022
Structural recognition of the mRNA 3’ UTR by PUF-8 restricts the lifespan of C. elegans, Zheng Xu, Jie Zhao, Minjie Hong, Chenming Zeng, Shouhong Guang, Yunyu Shi, 2021
A chromodomain protein mediates heterochromatin-directed piRNA expression, Xinya Huang, Peng Cheng, Chenchun Weng, Zongxiu Xu, Chenming Zeng, Xiangyang Chen, Chengming Zhu, Shouhong Guang, and Xuezhu Feng, 2021
Functional proteomics identifies a PICS complex required for piRNA maturation and chromosome segregation, Chenming Zeng, Chenchun Weng, Xiaoyang Wang, Yong-Hong Yan, Wen-Jun Li, Demin Xu, Minjie Hong, Shanhui Liao, Meng-Qiu Dong, Xuezhu Feng, Chao Xu, and Shouhong Guang, 2019
The USTC complex co-opts an ancient machinery to drive piRNA transcription in C. elegans, Chenchun Weng, Joanna Kosalka, Ahmet C. Berkyurek, Przemyslaw Stempor, Xuezhu Feng, Hui Mao, Chenming Zeng, Wen-Jun Li, Yong-Hong Yan, Meng-Qiu Dong, Natalia Rosalía Morero, Cecilia Zuliani, Orsolya Barabas, Julie Ahringer, Shouhong Guang, and Eric A. Miska, 2018
Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA, Chengming Zhu, Qi Yan, Chenchun Weng, Xinhao Hou, Hui Mao, Dun Liu, Xuezhu Feng, Shouhong Guang, 2018
A cytoplasmic Argonaute protein promotes the inheritance of RNAi, Fei Xu, Xuezhu Feng, Xiangyang Chen, Chenchun Weng, Qi Yan, Ting Xu, Minjie Hong, and Shouhong Guang, 2018
RdRP-synthesized antisense ribosomal siRNAs silence pre-rRNA via the nuclear RNAi pathway, Xufei Zhou, Xuezhu Feng, Hui Mao, Mu Li, Fei Xu, Kai Hu, and Shouhong Guang, 2017
The Nrde pathway mediates small RNA-directed histone H3 lysine 27 trimethylation in Caenorhabditis elegans, Hui Mao, Chengming Zhu, Dandan Zong, Chenchun Weng, Xiangwei Yang, Hui Huang, Dun Liu, Xuezhu Feng, and Shouhong Guang, 2015
Targeted Chromosomal Translocations and Essential Gene Knockout Using CRISPR/Cas9 Technology in Caenorhabditis elegans, Chen X, Li M, Feng X, Shouhong Guang, 2015
Nuclear RNAi Contributes to the Silencing of Off-Target Genes and Repetitive Sequences in Caenorhabditis elegans, Zhou X, Xu F, Mao H, Ji J, Yin M, Feng X, and Shouhong Guang, 2014
Dual sgRNA-directed gene knockout using CRISPR/Cas9 technology in Caenorhabditis elegans, Xiangyang Chen, Fei Xu, Chengming Zhu, Jiaojiao Ji, Xufei Zhou, Xuezhu Feng, and Shouhong Guang, 2014
Small regulatory RNAs inhibit RNA Polymerase II during the elongation phase of transcription, Guang, S., Bochner, A.F., Pavelec, D.M., Burkhart, K.B., Burton, N., and Kennedy, S., 2010
An Argonaute transports siRNAs from the cytoplasm to the nucleus, Guang, S., Bochner, A.F., Pavelec, D.M., Burkhart, K.B., Harding, S., Lachowiec, J., and Kennedy, S., 2008
Binding of hnRNP L to the pre-mRNA processing enhancer (PPE) of herpes simplex virus’ thymidine kinase gene enhances both polyadenylation and nucleocytoplasmic export of intronless mRNAs, Guang, Shouhong, Felthauser, A., and Mertz, J., 2005
PPE-like elements from intronless genes play additional roles in mRNA biogenesis than do ones from intron-containing genes, Guang, Shouhong and Mertz, J.E., 2005
