Professor | Xuezhu Feng | Asia Growth Partners

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Name	Xuezhu Feng
Contact Information	{'en': 'Email: fengxz@@@ustc.edu.cn', 'zh': '电子邮件：fengxz@@@ustc.edu.cn', 'de': 'E-Mail: fengxz@@@ustc.edu.cn'}
Language ability	English, Chinese
Province	Anhui

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Name

Xuezhu Feng

Contact Information

{'en': 'Email: fengxz@@@ustc.edu.cn', 'zh': '电子邮件：fengxz@@@ustc.edu.cn', 'de': 'E-Mail: fengxz@@@ustc.edu.cn'}

Language ability

English, Chinese

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Life Sciences
Academic Background & Achievements	1999 - Bachelor's degree in Clinical Medicine: Beijing Medical University 2007 - PhD in Molecular and Cellular Biology: University of Wisconsin-Madison
Work Experience	1999-2001 - Lecturer: Beijing Medical University, Department of Embryology 2007-2014 - Senior Scientist: Cellular Dynamics International Inc. 2014-present - Special Researcher: University of Science and Technology of China, School of Life Sciences

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Life Sciences

Academic Background & Achievements

1999 - Bachelor's degree in Clinical Medicine: Beijing Medical University
2007 - PhD in Molecular and Cellular Biology: University of Wisconsin-Madison

Work Experience

1999-2001 - Lecturer: Beijing Medical University, Department of Embryology
2007-2014 - Senior Scientist: Cellular Dynamics International Inc.
2014-present - Special Researcher: University of Science and Technology of China, School of Life Sciences

Areas of Focus	Regulation of RNA expression and processing in eukaryotic cells Transcriptional regulation mechanisms in eukaryotes Expression and regulation mechanisms of non-coding RNA in human pluripotent stem cells and their biological functions
Publications	Functional Proteomics Identifies a PICS Complex Required for piRNA Maturation and Chromosome Segregation, Chenming Zeng, Chenchun Weng, Xiaoyang Wang, Yong-Hong Yan, Wen-Jun Li, Demin Xu, Minjie Hong, Shanhui Liao, Meng-Qiu Dong, Xuezhu Feng, Chao Xu, Shouhong Guang, 2019 The USTC complex co-opts an ancient machinery to drive piRNA transcription in C. elegans, Chenchun Weng, Joanna Kosalka, Ahmet C. Berkyurek, Przemyslaw Stempor, Xuezhu Feng, Hui Mao, Chenming Zeng, Wen-Jun Li, Yong-Hong Yan, Meng-Qiu Dong, Natalia Rosalía Morero, Cecilia Zuliani, Orsolya Barabas, Julie Ahringer, Shouhong Guang, Eric A. Miska, 2018 Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA, Chengming Zhu, Qi Yan, Chenchun Weng, Xinhao Hou, Hui Mao, Dun Liu, Xuezhu Feng, Shouhong Guang, 2018 A cytoplasmic Argonaute protein promotes the inheritance of RNAi, Fei Xu, Xuezhu Feng, Xiangyang Chen, Chenchun Weng, Qi Yan, Ting Xu, Minjie Hong, Shouhong Guang, 2018 RNA-dependent RNA polymerases-synthesized antisense ribosomal siRNAs silence pre-rRNA via the nuclear RNAi pathway in C. elegans, Xufei Zhou, Xuezhu Feng, Hui Mao, Mu Li, Fei Xu, Kai Hu, Shouhong Guang, 2017 The Nrde pathway mediates small RNA-directed histone H3 lysine 27 trimethylation in Caenorhabditis elegans, Hui Mao, Chengming Zhu, Dandan Zong, Chenchun Weng, Xiangwei Yang, Hui Huang, Dun Liu, Xuezhu Feng, Shouhong Guang, 2015 Targeted Chromosomal Rearrangements via a Combinatorial Use of CRISPR/Cas9 and Cre/LoxP Technologies in Caenorhabditis elegans, Chen X, Liao S, Huang X, Xu T, Feng X, Guang S, 2018 Targeted Chromosomal Translocations and Essential Gene Knockout Using CRISPR/Cas9 Technology in Caenorhabditis elegans, Xiangyang Chen, Mu Li, Xuezhu Feng, Shouhong Guang, 2015 Nuclear RNAi Contributes to the Silencing of Off-Target Genes and Repetitive Sequences in Caenorhabditis elegans, Zhou X, Xu F, Mao H, Ji J, Meng Y, Feng X, Guang S, 2014 Protein kinase C mediated extraembryonic endoderm differentiation of human embryonic stem cells, Feng X, Zhang J, Smuga-Otto K, Tian S, Yu J, Stewart R, Thomson JA, 2012 Derivation of induced pluripotent stem cells from human peripheral blood T lymphocytes, Matthew E. Brown, Elizabeth Rondon, Deepika Rajesh, Amanda Mack, Rachel Lewis, Xuezhu Feng, Laura Jo Zitur, Randall D. Learish, Emile F. Nuwaysir, 2010 Mass spectrometry identifies and quantifies 74 unique histone H4 isoforms in differentiating human embryonic stem cells, Phanstiel D, Brumbaugh J, Berggren WT, Conard K, Feng X, Levenstein ME, McAlister GC, Thomson JA, Coon JJ, 2008 Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells, Xu RH, Peck RM, Li DS, Feng X, Ludwig T, Thomson JA, 2005

Areas of Focus

Regulation of RNA expression and processing in eukaryotic cells
Transcriptional regulation mechanisms in eukaryotes
Expression and regulation mechanisms of non-coding RNA in human pluripotent stem cells and their biological functions

Publications

Functional Proteomics Identifies a PICS Complex Required for piRNA Maturation and Chromosome Segregation, Chenming Zeng, Chenchun Weng, Xiaoyang Wang, Yong-Hong Yan, Wen-Jun Li, Demin Xu, Minjie Hong, Shanhui Liao, Meng-Qiu Dong, Xuezhu Feng, Chao Xu, Shouhong Guang, 2019
The USTC complex co-opts an ancient machinery to drive piRNA transcription in C. elegans, Chenchun Weng, Joanna Kosalka, Ahmet C. Berkyurek, Przemyslaw Stempor, Xuezhu Feng, Hui Mao, Chenming Zeng, Wen-Jun Li, Yong-Hong Yan, Meng-Qiu Dong, Natalia Rosalía Morero, Cecilia Zuliani, Orsolya Barabas, Julie Ahringer, Shouhong Guang, Eric A. Miska, 2018
Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA, Chengming Zhu, Qi Yan, Chenchun Weng, Xinhao Hou, Hui Mao, Dun Liu, Xuezhu Feng, Shouhong Guang, 2018
A cytoplasmic Argonaute protein promotes the inheritance of RNAi, Fei Xu, Xuezhu Feng, Xiangyang Chen, Chenchun Weng, Qi Yan, Ting Xu, Minjie Hong, Shouhong Guang, 2018
RNA-dependent RNA polymerases-synthesized antisense ribosomal siRNAs silence pre-rRNA via the nuclear RNAi pathway in C. elegans, Xufei Zhou, Xuezhu Feng, Hui Mao, Mu Li, Fei Xu, Kai Hu, Shouhong Guang, 2017
The Nrde pathway mediates small RNA-directed histone H3 lysine 27 trimethylation in Caenorhabditis elegans, Hui Mao, Chengming Zhu, Dandan Zong, Chenchun Weng, Xiangwei Yang, Hui Huang, Dun Liu, Xuezhu Feng, Shouhong Guang, 2015
Targeted Chromosomal Rearrangements via a Combinatorial Use of CRISPR/Cas9 and Cre/LoxP Technologies in Caenorhabditis elegans, Chen X, Liao S, Huang X, Xu T, Feng X, Guang S, 2018
Targeted Chromosomal Translocations and Essential Gene Knockout Using CRISPR/Cas9 Technology in Caenorhabditis elegans, Xiangyang Chen, Mu Li, Xuezhu Feng, Shouhong Guang, 2015
Nuclear RNAi Contributes to the Silencing of Off-Target Genes and Repetitive Sequences in Caenorhabditis elegans, Zhou X, Xu F, Mao H, Ji J, Meng Y, Feng X, Guang S, 2014
Protein kinase C mediated extraembryonic endoderm differentiation of human embryonic stem cells, Feng X, Zhang J, Smuga-Otto K, Tian S, Yu J, Stewart R, Thomson JA, 2012
Derivation of induced pluripotent stem cells from human peripheral blood T lymphocytes, Matthew E. Brown, Elizabeth Rondon, Deepika Rajesh, Amanda Mack, Rachel Lewis, Xuezhu Feng, Laura Jo Zitur, Randall D. Learish, Emile F. Nuwaysir, 2010
Mass spectrometry identifies and quantifies 74 unique histone H4 isoforms in differentiating human embryonic stem cells, Phanstiel D, Brumbaugh J, Berggren WT, Conard K, Feng X, Levenstein ME, McAlister GC, Thomson JA, Coon JJ, 2008
Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells, Xu RH, Peck RM, Li DS, Feng X, Ludwig T, Thomson JA, 2005

Rna Expression Rna Processing Eukaryotic Cells Transcriptional Regulation Non-Coding Rna Pluripotent Stem Cells Biological Functions Gene Expression Molecular Biology Cellular Biology

Yijun Qi - Tsinghua University

Kang Lan - Tongji University

Shi Songhai - Tsinghua University

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