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Haiyan Liu
Life Science
University of Science and Technology of China
Anhui
Language: English, Chinese
Protein Structure
Dynamics
Computer Simulation
Protein Design
Synthetic Biology
Spatial Structure
Experimental Methods
Biomolecular Design
Enzyme Catalysis
Neural Networks
Areas of Focus
- Computer simulation methods and applications of protein spatial structure and dynamics
- Protein design theory and experimental methods and their application in synthetic biology
Work Experience
- Current - Professor and Doctoral Supervisor at the School of Life Sciences and Medicine, University of Science and Technology of China
Academic Background & Achievements
- 1990 - Bachelor's and Doctorate: University of Science and Technology of China, Department of Biology
- 1996 - Doctorate: University of Science and Technology of China
- 1993-1995 - Joint training at ETH Zurich, Physical Chemistry Laboratory
- 1998-2000 - Postdoctoral research at Duke University and University of North Carolina
- Awarded Guo Moruo Prize
- 2001 - Received National Outstanding Youth Fund
- 2004 - Received Anhui Youth Science and Technology Award
Publications
- De novo protein design with a denoising diffusion network independent of pre-trained structure prediction models, Yufeng Liu, Sheng Wang, Jixin Dong, Linghui Chen, Xinyu Wang, Lei Wang, Fudong Li, Chenchen Wang, Jiahai Zhang, Yuzhu Wang, Si Wei, Quan Chen*, Haiyan Liu*, 2024
- De novo Design of Cavity-containing Proteins with a Backbone-centred Neural Network Energy Function, Xu, Yang; Hu, Xiuhon; Wang, Chenchen; Liu, Yongrui Liu; Chen, Quan*; Liu, Haiyan*, 2024
- Combined prediction and design reveals the target recognition mechanism of an intrinsically disordered protein interaction domain, Hu, Xiuhong; Xu, Yang; Wang, Chenchen; Liu, Yufeng Liu; Zhang, Lu; Zhang, Jiahai; Wang, Wenning*; Chen, Quan*; Liu, Haiyan*, 2023
- Rotamer-free protein sequence design based on deep learning and self-consistency, Liu, Yufeng; Zhang, Lu; Wang, Weilun; Zhu, Min; Wang, Chenchen; Li, Fudong;, Zhang, Jiahai; Li, Houqiang; Chen, Quan*; Liu, Haiyan*, 2022
- A backbone-centred energy function of neural networks for protein design, Huang, Bin; Xu. Yang; Hu,Xiuhon; Liu, Yongrui; Liao, Shanhui; Zhang, Jiahai; Huang, Chengdong; Hong, Jingjun; Chen, Quan*; Liu, Haiyan*, 2022
Awards
- Guo Moruo Prize
- 2001: National Outstanding Youth Fund
- 2004: Anhui Youth Science and Technology Award
