Areas of Focus
- Neurodegenerative diseases, autoimmune diseases, cancer research
- Protein structure and dynamics, epigenetics, histone modification
- Peptide drug development, GPCR and ion channel targeting
- Spectroscopy methods for protein dynamics, NMR, ESR, FLIM
- Electron biology, high-field ESR, biological catalysis
Work Experience
- 2003-2006 - Postdoctoral Research in Biochemistry: Vanderbilt University
- 2009-2014/2020-present - Deputy Director: High Magnetic Field Science Center, Chinese Academy of Sciences
Academic Background & Achievements
- 1995 - Bachelor's degrees in Biochemical Engineering and Applied Electronic Technology: Shanghai Jiao Tong University
- 1997 - Master's degree in Molecular Biology: Shanghai Jiao Tong University
- 2003 - Ph.D. in Molecular Biophysics: Florida State University/National High Magnetic Field Laboratory
Publications
- Cryo-EM structure of the hyperpolarization-activated inwardly rectifying potassium channel KAT1 from Arabidopsis, Li, S., F. Yang, D. Sun, Y. Zhang, M. Zhang, S. Liu, P. Zhou, C. Shi, L. Zhang, and C. Tian, 2020
- Structural Insights into Human Acid-sensing Ion Channel 1a Inhibition by Snake Toxin Mambalgin1, Sun, D., S. Liu, S. Li, M. Zhang, F. Yang, M. Wen, P. Shi, T. Wang, M. Pan, S. Chang, X. Zhang, L. Zhang, C. Tian, and L. Liu, 2020
- The New Salicylaldehyde S,S-Propanedithioacetal Ester Enables N-to-C Sequential Native Chemical Ligation and Ser/Thr Ligation for Chemical Protein Synthesis, Huang, D. L., Y. Li, J. Liang, L. Yu, M. Xue, X. X. Cao, B. Xiao, C. L. Tian, L. Liu, and J. S. Zheng, 2020
- Chemical Synthesis of Native S-Palmitoylated Membrane Proteins through Removable- Backbone-Modification- Assisted Ser/Thr Ligation, Huang, D. L., C. Montigny, Y. Zheng, V. Beswick, Y. Li, X. X. Cao, T. Barbot, C. Jaxel, J. Liang, M. Xue, C. L. Tian, N. Jamin, and J. S. Zheng, 2020
- Synthesis of Disulfide Surrogate Peptides Incorporating Large-Span Surrogate Bridges Through a Native-Chemical-Ligation-Assisted Diaminodiacid Strategy, Qu, Q., S. Gao, F. Wu, M. G. Zhang, Y. Li, L. H. Zhang, D. Bierer, C. L. Tian, J. S. Zheng, and L. Liu, 2020
- Chemical synthesis and biological activity of peptides incorporating an ether bridge as a surrogate for a disulfide bond, Zhao, Rui, Pan Shi, Junyou Chen, Shuaishuai Sun, Jingnan Chen, Jibin Cui, Fangming Wu, Gemin Fang, Changlin Tian, Jing Shi, Donald Bierer, Lei Liu, and Yi-Ming Li, 2020
- A genetically encoded small-size fluorescent pair reveals allosteric conformational changes of G proteins upon its interaction with GPCRs by fluorescence lifetime based FRET, Shi, P., Y. Zhang, P. Lv, W. Fang, S. Ling, X. Guo, D. Li, S. Liu, D. Sun, L. Zhang, D. Liu, J. S. Zheng, and C. Tian, 2020
- Chemical synthesis of di-ubiquitin modified histones for further biochemical studies, Li, J. B., J. Liang, and C. Tian, 2020
- Single-particle cryo-EM structural studies of the beta2AR-Gs complex bound with a full agonist formoterol, Zhang, Y., F. Yang, S. Ling, P. Lv, Y. Zhou, W. Fang, W. Sun, L. Zhang, P. Shi, and C. Tian, 2020
- Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF, Gong, Hongri, Yan Gao, Xiaoting Zhou, Yu Xiao, Weiwei Wang, Yanting Tang, Shan Zhou, Yuying Zhang, Wenxin Ji, Lu Yu, Changlin Tian, Sin Man Lam, Guanghou Shui, Luke W. Guddat, Luet-Lok Wong, Quan Wang, and Zihe Rao, 2020
Awards
- National Distinguished Young Scholar