Professor | 田长麟 | 数字化转型顾问

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Name	田长麟
Contact Information	cltian@ustc.edu.cn
Language ability	英语, 中文
Province	安徽

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Name

田长麟

Contact Information

cltian@ustc.edu.cn

Language ability

英语, 中文

Province

安徽

University/Lab Affiliation and Title	中国科学技术大学
Faculty	Life Sciences
Academic Background & Achievements	1995年 - 生化工程和应用电子技术学士学位：上海交通大学 1997年 - 分子生物学硕士学位：上海交通大学 2003年 - 分子生物物理博士学位：佛罗里达州立大学/国家强磁场实验室
Work Experience	2003-2006年 - 生物化学博士后研究：范德堡大学 2009-2014年/2020年至今 - 副主任：中科院强磁场科学中心
Awards	国家杰出青年科学基金获得者

University/Lab Affiliation and Title

中国科学技术大学

Faculty

Life Sciences

Academic Background & Achievements

1995年 - 生化工程和应用电子技术学士学位：上海交通大学
1997年 - 分子生物学硕士学位：上海交通大学
2003年 - 分子生物物理博士学位：佛罗里达州立大学/国家强磁场实验室

Work Experience

2003-2006年 - 生物化学博士后研究：范德堡大学
2009-2014年/2020年至今 - 副主任：中科院强磁场科学中心

Awards

国家杰出青年科学基金获得者

Areas of Focus	神经退行性疾病，自身免疫疾病，癌症研究蛋白质结构与动态，表观遗传学，组蛋白修饰多肽药物开发，GPCR和离子通道靶向蛋白质动态的光谱学方法，NMR，ESR，FLIM 电子生物学，高场ESR，生物催化
Publications	Cryo-EM structure of the hyperpolarization-activated inwardly rectifying potassium channel KAT1 from Arabidopsis, Li, S., F. Yang, D. Sun, Y. Zhang, M. Zhang, S. Liu, P. Zhou, C. Shi, L. Zhang, and C. Tian, 2020 Structural Insights into Human Acid-sensing Ion Channel 1a Inhibition by Snake Toxin Mambalgin1, Sun, D., S. Liu, S. Li, M. Zhang, F. Yang, M. Wen, P. Shi, T. Wang, M. Pan, S. Chang, X. Zhang, L. Zhang, C. Tian, and L. Liu, 2020 The New Salicylaldehyde S,S-Propanedithioacetal Ester Enables N-to-C Sequential Native Chemical Ligation and Ser/Thr Ligation for Chemical Protein Synthesis, Huang, D. L., Y. Li, J. Liang, L. Yu, M. Xue, X. X. Cao, B. Xiao, C. L. Tian, L. Liu, and J. S. Zheng, 2020 Chemical Synthesis of Native S-Palmitoylated Membrane Proteins through Removable- Backbone-Modification- Assisted Ser/Thr Ligation, Huang, D. L., C. Montigny, Y. Zheng, V. Beswick, Y. Li, X. X. Cao, T. Barbot, C. Jaxel, J. Liang, M. Xue, C. L. Tian, N. Jamin, and J. S. Zheng, 2020 Synthesis of Disulfide Surrogate Peptides Incorporating Large-Span Surrogate Bridges Through a Native-Chemical-Ligation-Assisted Diaminodiacid Strategy, Qu, Q., S. Gao, F. Wu, M. G. Zhang, Y. Li, L. H. Zhang, D. Bierer, C. L. Tian, J. S. Zheng, and L. Liu, 2020 Chemical synthesis and biological activity of peptides incorporating an ether bridge as a surrogate for a disulfide bond, Zhao, Rui, Pan Shi, Junyou Chen, Shuaishuai Sun, Jingnan Chen, Jibin Cui, Fangming Wu, Gemin Fang, Changlin Tian, Jing Shi, Donald Bierer, Lei Liu, and Yi-Ming Li, 2020 A genetically encoded small-size fluorescent pair reveals allosteric conformational changes of G proteins upon its interaction with GPCRs by fluorescence lifetime based FRET, Shi, P., Y. Zhang, P. Lv, W. Fang, S. Ling, X. Guo, D. Li, S. Liu, D. Sun, L. Zhang, D. Liu, J. S. Zheng, and C. Tian, 2020 Chemical synthesis of di-ubiquitin modified histones for further biochemical studies, Li, J. B., J. Liang, and C. Tian, 2020 Single-particle cryo-EM structural studies of the beta2AR-Gs complex bound with a full agonist formoterol, Zhang, Y., F. Yang, S. Ling, P. Lv, Y. Zhou, W. Fang, W. Sun, L. Zhang, P. Shi, and C. Tian, 2020 Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF, Gong, Hongri, Yan Gao, Xiaoting Zhou, Yu Xiao, Weiwei Wang, Yanting Tang, Shan Zhou, Yuying Zhang, Wenxin Ji, Lu Yu, Changlin Tian, Sin Man Lam, Guanghou Shui, Luke W. Guddat, Luet-Lok Wong, Quan Wang, and Zihe Rao, 2020

Areas of Focus

神经退行性疾病，自身免疫疾病，癌症研究
蛋白质结构与动态，表观遗传学，组蛋白修饰
多肽药物开发，GPCR和离子通道靶向
蛋白质动态的光谱学方法，NMR，ESR，FLIM
电子生物学，高场ESR，生物催化

Publications

Cryo-EM structure of the hyperpolarization-activated inwardly rectifying potassium channel KAT1 from Arabidopsis, Li, S., F. Yang, D. Sun, Y. Zhang, M. Zhang, S. Liu, P. Zhou, C. Shi, L. Zhang, and C. Tian, 2020
Structural Insights into Human Acid-sensing Ion Channel 1a Inhibition by Snake Toxin Mambalgin1, Sun, D., S. Liu, S. Li, M. Zhang, F. Yang, M. Wen, P. Shi, T. Wang, M. Pan, S. Chang, X. Zhang, L. Zhang, C. Tian, and L. Liu, 2020
The New Salicylaldehyde S,S-Propanedithioacetal Ester Enables N-to-C Sequential Native Chemical Ligation and Ser/Thr Ligation for Chemical Protein Synthesis, Huang, D. L., Y. Li, J. Liang, L. Yu, M. Xue, X. X. Cao, B. Xiao, C. L. Tian, L. Liu, and J. S. Zheng, 2020
Chemical Synthesis of Native S-Palmitoylated Membrane Proteins through Removable- Backbone-Modification- Assisted Ser/Thr Ligation, Huang, D. L., C. Montigny, Y. Zheng, V. Beswick, Y. Li, X. X. Cao, T. Barbot, C. Jaxel, J. Liang, M. Xue, C. L. Tian, N. Jamin, and J. S. Zheng, 2020
Synthesis of Disulfide Surrogate Peptides Incorporating Large-Span Surrogate Bridges Through a Native-Chemical-Ligation-Assisted Diaminodiacid Strategy, Qu, Q., S. Gao, F. Wu, M. G. Zhang, Y. Li, L. H. Zhang, D. Bierer, C. L. Tian, J. S. Zheng, and L. Liu, 2020
Chemical synthesis and biological activity of peptides incorporating an ether bridge as a surrogate for a disulfide bond, Zhao, Rui, Pan Shi, Junyou Chen, Shuaishuai Sun, Jingnan Chen, Jibin Cui, Fangming Wu, Gemin Fang, Changlin Tian, Jing Shi, Donald Bierer, Lei Liu, and Yi-Ming Li, 2020
A genetically encoded small-size fluorescent pair reveals allosteric conformational changes of G proteins upon its interaction with GPCRs by fluorescence lifetime based FRET, Shi, P., Y. Zhang, P. Lv, W. Fang, S. Ling, X. Guo, D. Li, S. Liu, D. Sun, L. Zhang, D. Liu, J. S. Zheng, and C. Tian, 2020
Chemical synthesis of di-ubiquitin modified histones for further biochemical studies, Li, J. B., J. Liang, and C. Tian, 2020
Single-particle cryo-EM structural studies of the beta2AR-Gs complex bound with a full agonist formoterol, Zhang, Y., F. Yang, S. Ling, P. Lv, Y. Zhou, W. Fang, W. Sun, L. Zhang, P. Shi, and C. Tian, 2020
Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF, Gong, Hongri, Yan Gao, Xiaoting Zhou, Yu Xiao, Weiwei Wang, Yanting Tang, Shan Zhou, Yuying Zhang, Wenxin Ji, Lu Yu, Changlin Tian, Sin Man Lam, Guanghou Shui, Luke W. Guddat, Luet-Lok Wong, Quan Wang, and Zihe Rao, 2020

神经退行性疾病自身免疫疾病癌症蛋白质结构动态表观遗传学组蛋白修饰多肽药物 Gpcr 离子通道

裴钢 - 同济大学

谢欣 - 同济大学

刘剑峰 - 华中科技大学

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