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田长麟
Life Science
中国科学技术大学
安徽
Language: 英语, 中文
神经退行性疾病
自身免疫疾病
癌症
蛋白质结构
动态
表观遗传学
组蛋白修饰
多肽药物
Gpcr
离子通道
Areas of Focus
- 神经退行性疾病，自身免疫疾病，癌症研究
- 蛋白质结构与动态，表观遗传学，组蛋白修饰
- 多肽药物开发，GPCR和离子通道靶向
- 蛋白质动态的光谱学方法，NMR，ESR，FLIM
- 电子生物学，高场ESR，生物催化
Work Experience
- 2003-2006年 - 生物化学博士后研究：范德堡大学
- 2009-2014年/2020年至今 - 副主任：中科院强磁场科学中心
Academic Background & Achievements
- 1995年 - 生化工程和应用电子技术学士学位：上海交通大学
- 1997年 - 分子生物学硕士学位：上海交通大学
- 2003年 - 分子生物物理博士学位：佛罗里达州立大学/国家强磁场实验室
Publications
- Cryo-EM structure of the hyperpolarization-activated inwardly rectifying potassium channel KAT1 from Arabidopsis, Li, S., F. Yang, D. Sun, Y. Zhang, M. Zhang, S. Liu, P. Zhou, C. Shi, L. Zhang, and C. Tian, 2020
- Structural Insights into Human Acid-sensing Ion Channel 1a Inhibition by Snake Toxin Mambalgin1, Sun, D., S. Liu, S. Li, M. Zhang, F. Yang, M. Wen, P. Shi, T. Wang, M. Pan, S. Chang, X. Zhang, L. Zhang, C. Tian, and L. Liu, 2020
- The New Salicylaldehyde S,S-Propanedithioacetal Ester Enables N-to-C Sequential Native Chemical Ligation and Ser/Thr Ligation for Chemical Protein Synthesis, Huang, D. L., Y. Li, J. Liang, L. Yu, M. Xue, X. X. Cao, B. Xiao, C. L. Tian, L. Liu, and J. S. Zheng, 2020
- Chemical Synthesis of Native S-Palmitoylated Membrane Proteins through Removable- Backbone-Modification- Assisted Ser/Thr Ligation, Huang, D. L., C. Montigny, Y. Zheng, V. Beswick, Y. Li, X. X. Cao, T. Barbot, C. Jaxel, J. Liang, M. Xue, C. L. Tian, N. Jamin, and J. S. Zheng, 2020
- Synthesis of Disulfide Surrogate Peptides Incorporating Large-Span Surrogate Bridges Through a Native-Chemical-Ligation-Assisted Diaminodiacid Strategy, Qu, Q., S. Gao, F. Wu, M. G. Zhang, Y. Li, L. H. Zhang, D. Bierer, C. L. Tian, J. S. Zheng, and L. Liu, 2020
- Chemical synthesis and biological activity of peptides incorporating an ether bridge as a surrogate for a disulfide bond, Zhao, Rui, Pan Shi, Junyou Chen, Shuaishuai Sun, Jingnan Chen, Jibin Cui, Fangming Wu, Gemin Fang, Changlin Tian, Jing Shi, Donald Bierer, Lei Liu, and Yi-Ming Li, 2020
- A genetically encoded small-size fluorescent pair reveals allosteric conformational changes of G proteins upon its interaction with GPCRs by fluorescence lifetime based FRET, Shi, P., Y. Zhang, P. Lv, W. Fang, S. Ling, X. Guo, D. Li, S. Liu, D. Sun, L. Zhang, D. Liu, J. S. Zheng, and C. Tian, 2020
- Chemical synthesis of di-ubiquitin modified histones for further biochemical studies, Li, J. B., J. Liang, and C. Tian, 2020
- Single-particle cryo-EM structural studies of the beta2AR-Gs complex bound with a full agonist formoterol, Zhang, Y., F. Yang, S. Ling, P. Lv, Y. Zhou, W. Fang, W. Sun, L. Zhang, P. Shi, and C. Tian, 2020
- Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF, Gong, Hongri, Yan Gao, Xiaoting Zhou, Yu Xiao, Weiwei Wang, Yanting Tang, Shan Zhou, Yuying Zhang, Wenxin Ji, Lu Yu, Changlin Tian, Sin Man Lam, Guanghou Shui, Luke W. Guddat, Luet-Lok Wong, Quan Wang, and Zihe Rao, 2020
Awards
- 国家杰出青年科学基金获得者
