Professor | Long Dong | Asia Growth Partners

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Name	Long Dong
Contact Information	{'en': 'Email: dlong[at]ustc.edu.cn', 'zh': '电子邮件: dlong[at]ustc.edu.cn', 'de': 'E-Mail: dlong[at]ustc.edu.cn'}
Language ability	English, Chinese
Province	Anhui

Upload Avatar (500 x 500)

Name

Long Dong

Contact Information

{'en': 'Email: dlong[at]ustc.edu.cn', 'zh': '电子邮件: dlong[at]ustc.edu.cn', 'de': 'E-Mail: dlong[at]ustc.edu.cn'}

Language ability

English, Chinese

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Life Sciences
Academic Background & Achievements	2005 - Bachelor's Degree: Wuhan University 2010 - Doctorate: National University of Singapore 2018 - Received the National Natural Science Foundation of China 'Outstanding Youth Science Fund'
Work Experience	2010-2015 - Postdoctoral Research: National High Magnetic Field Laboratory, USA and University of Toronto, Canada 2015-present - Joined University of Science and Technology of China, School of Life Sciences and National Research Center for Microscale Material Science
Awards	2018: National Natural Science Foundation of China 'Outstanding Youth Science Fund'

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Life Sciences

Academic Background & Achievements

2005 - Bachelor's Degree: Wuhan University
2010 - Doctorate: National University of Singapore
2018 - Received the National Natural Science Foundation of China 'Outstanding Youth Science Fund'

Work Experience

2010-2015 - Postdoctoral Research: National High Magnetic Field Laboratory, USA and University of Toronto, Canada
2015-present - Joined University of Science and Technology of China, School of Life Sciences and National Research Center for Microscale Material Science

Awards

2018: National Natural Science Foundation of China 'Outstanding Youth Science Fund'

Areas of Focus	Nuclear Magnetic Resonance Spectroscopy Biophysical Chemistry
Publications	Unveiling the invisible druggable conformations of GDP-bound inactive Ras, D. Liu, Y. Mao, X. Gu, Y. Zhou, D. Long, 2021 Millisecond Allosteric Dynamics of Activated Ras Reproduced with a Slowly Hydrolyzable GTP Analogue, X. Chen, H. Gao, D. Long, 2021 NMR-Derived Conformational Ensemble of State 1 of Activated Ras Reveals Insights into a Druggable Pocket, D. Liu, X. Chen, D. Long, 2020 Extending the lifetime of native GTP-bound Ras for site-resolved NMR measurements: Quantifying the allosteric dynamics, X. Chen, H. Yao, H. Wang, Y. Mao, D. Liu, D. Long, 2019 Atomistic Insights into the Functional Instability of the Second Helix of Fatty Acid Binding Protein, P. Cheng, D. Liu, P. X. Chee, D. Yang, D. Long, 2019 Characterization of the interaction interface and conformational dynamics of human TGIF1 homeodomain upon the binding of consensus DNA, S. Li, R. Hu, H. Yao, D. Long, F. Luo, X. Zhou, X. Zhang, M. Liu, J. Zhu, Y. Yang, 2018 Probing transient release of membrane-sequestered tyrosine-based signaling motif by solution NMR spectroscopy, H. Wang, S. Wang, C. Li, H. Li, Y. Mao, W. Liu, C. Xu, D. Long, 2017 Microsecond timescale dynamics of GDP-bound Ras underlies the formation of novel inhibitor-binding pockets, Y. Mao, H. Yao, H. Wang, P. Cheng, D. Long, 2016 Probing invisible, excited protein states by non-uniformly sampled pseudo-4D CEST spectroscopy, D. Long, F. Delaglio, A. Sekhar, L. E. Kay, 2015 Triple resonance-based 13Cα and 13Cβ CEST experiments for studies of ms timescale dynamics in proteins, D. Long, A. Sekhar, L. E. Kay, 2014 Measuring hydrogen exchange rates in invisible protein excited states, D. Long, G. Bouvignies, L. E. Kay, 2014 A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues, D. Long, C. B. Marshall, G. Bouvignies, M. T. Mazhab-Jafari, M. J. Smith, M. Ikura, L. E. Kay, 2013 Carbon relaxation in 13Cα-Hα and 13Cα-Dα spin pairs as a probe of backbone dynamics in proteins, H. Sun, D. Long, R. Brüschweiler, V. Tugarinov, 2013 Directional selection precedes conformational selection in ubiquitin-UIM binding, D. Long, R. Brüschweiler, 2013 Structural and entropic allosteric signal transduction strength via correlated motions, D. Long, R. Brüschweiler, 2012 Atomistic kinetic model for population shift and allostery in biomolecules, D. Long, R. Brüschweiler, 2011 Toward a predictive understanding of slow methyl group dynamics in proteins, D. Long, D.W. Li, K. Walter, C. Griesinger, R. Brüschweiler, 2011 In silico elucidation of the recognition dynamics of ubiquitin, D. Long, R. Brüschweiler, 2011

Areas of Focus

Nuclear Magnetic Resonance Spectroscopy
Biophysical Chemistry

Publications

Unveiling the invisible druggable conformations of GDP-bound inactive Ras, D. Liu, Y. Mao, X. Gu, Y. Zhou, D. Long, 2021
Millisecond Allosteric Dynamics of Activated Ras Reproduced with a Slowly Hydrolyzable GTP Analogue, X. Chen, H. Gao, D. Long, 2021
NMR-Derived Conformational Ensemble of State 1 of Activated Ras Reveals Insights into a Druggable Pocket, D. Liu, X. Chen, D. Long, 2020
Extending the lifetime of native GTP-bound Ras for site-resolved NMR measurements: Quantifying the allosteric dynamics, X. Chen, H. Yao, H. Wang, Y. Mao, D. Liu, D. Long, 2019
Atomistic Insights into the Functional Instability of the Second Helix of Fatty Acid Binding Protein, P. Cheng, D. Liu, P. X. Chee, D. Yang, D. Long, 2019
Characterization of the interaction interface and conformational dynamics of human TGIF1 homeodomain upon the binding of consensus DNA, S. Li, R. Hu, H. Yao, D. Long, F. Luo, X. Zhou, X. Zhang, M. Liu, J. Zhu, Y. Yang, 2018
Probing transient release of membrane-sequestered tyrosine-based signaling motif by solution NMR spectroscopy, H. Wang, S. Wang, C. Li, H. Li, Y. Mao, W. Liu, C. Xu, D. Long, 2017
Microsecond timescale dynamics of GDP-bound Ras underlies the formation of novel inhibitor-binding pockets, Y. Mao, H. Yao, H. Wang, P. Cheng, D. Long, 2016
Probing invisible, excited protein states by non-uniformly sampled pseudo-4D CEST spectroscopy, D. Long, F. Delaglio, A. Sekhar, L. E. Kay, 2015
Triple resonance-based 13Cα and 13Cβ CEST experiments for studies of ms timescale dynamics in proteins, D. Long, A. Sekhar, L. E. Kay, 2014
Measuring hydrogen exchange rates in invisible protein excited states, D. Long, G. Bouvignies, L. E. Kay, 2014
A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues, D. Long, C. B. Marshall, G. Bouvignies, M. T. Mazhab-Jafari, M. J. Smith, M. Ikura, L. E. Kay, 2013
Carbon relaxation in 13Cα-Hα and 13Cα-Dα spin pairs as a probe of backbone dynamics in proteins, H. Sun, D. Long, R. Brüschweiler, V. Tugarinov, 2013
Directional selection precedes conformational selection in ubiquitin-UIM binding, D. Long, R. Brüschweiler, 2013
Structural and entropic allosteric signal transduction strength via correlated motions, D. Long, R. Brüschweiler, 2012
Atomistic kinetic model for population shift and allostery in biomolecules, D. Long, R. Brüschweiler, 2011
Toward a predictive understanding of slow methyl group dynamics in proteins, D. Long, D.W. Li, K. Walter, C. Griesinger, R. Brüschweiler, 2011
In silico elucidation of the recognition dynamics of ubiquitin, D. Long, R. Brüschweiler, 2011

Nmr Spectroscopy Biophysics Chemistry Molecular Structure Dynamics Proteins Nucleic Acids Drug Development Computational Science

Senfang Sui - Tsinghua University

Sheng Ye - Zhejiang University

Yong Wang - Zhejiang University

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