Professor | Xiaoyuan Song | Asia Growth Partners

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Name	Xiaoyuan Song
Contact Information	songxy5@ustc.edu.cn
Language ability	English, Chinese
Province	Anhui

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Name

Xiaoyuan Song

Contact Information

songxy5@ustc.edu.cn

Language ability

English, Chinese

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Life Sciences
Academic Background & Achievements	1996 - Bachelor's degree in Biology: Beijing Normal University 1999 - Master's degree in Biology: Beijing Normal University 2006 - Ph.D. in Molecular, Cellular, and Developmental Biology: University of Rochester Postdoctoral research at University of California, San Diego Received Cancer Research Institute Postdoctoral Fellowship
Work Experience	2012-Present - University of Science and Technology of China - Associate Professor
Awards	Cancer Research Institute Postdoctoral Fellowship

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Life Sciences

Academic Background & Achievements

1996 - Bachelor's degree in Biology: Beijing Normal University
1999 - Master's degree in Biology: Beijing Normal University
2006 - Ph.D. in Molecular, Cellular, and Developmental Biology: University of Rochester
Postdoctoral research at University of California, San Diego
Received Cancer Research Institute Postdoctoral Fellowship

Work Experience

2012-Present - University of Science and Technology of China - Associate Professor

Awards

Cancer Research Institute Postdoctoral Fellowship

Areas of Focus	Role of 3D spatial transcriptional regulation in brain aging Transcriptional regulation of lncRNA and chromatin interactions in meiosis and spermatogenesis
Publications	Machine-learning and scRNA-Seq-based diagnostic and prognostic models illustrating survival and therapy response of lung adenocarcinoma., Cheng Q., Zhao W., Song X., Jin T., 2024 piR-36249 and DHX36 together inhibit testicular cancer cells progression by upregulating OAS2., Wang Q.#, Chen P.#, Wang X.#, Wu Y., Xia K., Mu X., Xuan Q., Xiao J., He Y., Liu W., Song X., Sun F, 2023 NicE-C efficiently reveals open chromatin-associated chromosome interactions at high resolution., Luo Z.#, Zhang R.#, Hu T.#, Zhu Y., Wu Y., Li W., Zhang Z., Yao X., Liang H., Song X., 2022 The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum., Wang F.#, Wang Q.#, Liu B.#, Mei L., Ma S., Wang S., Wang R., Zhang Y., Niu C., Xiong Z., Zheng Y., Zhang Z., Shi J., Song X., 2021 RGL2 as an age-dependent factor regulates colon cancer progression., Cheng Q., Wu Y, Xia H., Song X., 2021 Rearrangement of macronucleus chromosomes correspond to TAD-like structures of micronucleus chromosomes in Tetrahymena thermophila., Luo Z.#, Hu T. , Jiang H., Wang R., Xu Q., Zhang S., Cao J., Song X., 2020 Reorganized 3D genome structures support transcriptional regulation in mouse spermatogenesis., Luo Z.#, Wang X.#, Jiang H.#, Wang R.#, Chen J., Chen Y., Xu Q., Cao J., Gong X., Wu J., Yang Y., Li W., Han C., Cheng YC., Rosenfeld MG., Sun F., Song X., 2020 New insights into chronological mobility of retrotransposable elements in vivo., Ghanam AR., Cao J., Ouyang X., and Song X., 2019 A long noncoding RNA cluster-based genomic locus maintains proper development and visual function., Wang F.#, Ren D.#, Liang X.#, Ke S., Zhang B., Hu B., Song X., Wang X., 2019 The key role of CYC2 during meiosis in Tetrahymena thermophila., Xu Q.#, Wang R.#, Ghanam AR., Yan G., Miao W., Song X., 2016 Three-dimensional regulation of transcription., Cao J., Luo Z., Cheng Q., Xu Q., Zhang Y., Wang F., Wu Y., Song X., 2015 The nonhistone, N-terminal tail of an essential, chimeric H2A variant regulates mitotic H3-S10 dephosphorylation., Song X., Bowen J., Miao W., Liu Y., and Gorovsky MA., 2012 Promoter-associated noncoding RNA from the CCND1 promoter., Song X.#, Wang X.#, Arai S. and Kurokawa R., 2012 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response., Harismendy O.#, Notani D.#, Song X., Rahim NG., Tanasa B., Heintzman N., Ren B., Fu XD., Topol EJ., Rosenfeld MG, and Frazer KA, 2011 The Long Arm of Long Noncoding RNAs: Roles as Sensors Regulating Gene Transcriptional Programs., Wang X.# and Song X.#, Glass CK., and Rosenfeld MG, 2011 Induced ncRNAs allosterically modify RNA binding proteins in cis to inhibit transcription., Wang X., Arai S.%, Song X.%, Reichart D., Du K., Pascual G., Tempst P., Rosenfeld MG.#, Glass CK.#, and Kurokawa R.#, 2008 Phosphorylation of the SQ H2A.X motif is required for proper meiosis and mitosis in Tetrahymena thermophila., Song, X.#, Gjoneska E.#, Ren Q.#, Taverna SD., Allis C.D., and Gorovsky MA., 2007 Unphosphorylated H1 is enriched in a specific region of the promoter when CDC2 is down-regulated during starvation., Song X. and Gorovsky MA., 2007 A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila., Shang Y., Song X., Bowen J., Corstanje R., Gao Y., Gaertig J., and Gorovsky MA.*, 2002

Areas of Focus

Role of 3D spatial transcriptional regulation in brain aging
Transcriptional regulation of lncRNA and chromatin interactions in meiosis and spermatogenesis

Publications

Machine-learning and scRNA-Seq-based diagnostic and prognostic models illustrating survival and therapy response of lung adenocarcinoma., Cheng Q., Zhao W., Song X.*, Jin T.*, 2024
piR-36249 and DHX36 together inhibit testicular cancer cells progression by upregulating OAS2., Wang Q.#, Chen P.#, Wang X.#, Wu Y., Xia K., Mu X., Xuan Q., Xiao J., He Y., Liu W., Song X.*, Sun F*, 2023
NicE-C efficiently reveals open chromatin-associated chromosome interactions at high resolution., Luo Z.#, Zhang R.#, Hu T.#, Zhu Y., Wu Y., Li W., Zhang Z., Yao X., Liang H., Song X.*, 2022
The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum., Wang F.#, Wang Q.#, Liu B.#, Mei L., Ma S., Wang S., Wang R., Zhang Y., Niu C., Xiong Z., Zheng Y., Zhang Z., Shi J., Song X.*, 2021
RGL2 as an age-dependent factor regulates colon cancer progression., Cheng Q., Wu Y, Xia H.*, Song X.*, 2021
Rearrangement of macronucleus chromosomes correspond to TAD-like structures of micronucleus chromosomes in Tetrahymena thermophila., Luo Z.*#, Hu T. *, Jiang H., Wang R., Xu Q., Zhang S., Cao J., Song X.*, 2020
Reorganized 3D genome structures support transcriptional regulation in mouse spermatogenesis., Luo Z.#, Wang X.#, Jiang H.#, Wang R.#, Chen J., Chen Y., Xu Q., Cao J., Gong X., Wu J., Yang Y., Li W., Han C., Cheng YC., Rosenfeld MG., Sun F.*, Song X.*, 2020
New insights into chronological mobility of retrotransposable elements in vivo., Ghanam AR., Cao J., Ouyang X., and Song X.*, 2019
A long noncoding RNA cluster-based genomic locus maintains proper development and visual function., Wang F.#, Ren D.#, Liang X.#, Ke S., Zhang B., Hu B.*, Song X.*, Wang X.*, 2019
The key role of CYC2 during meiosis in Tetrahymena thermophila., Xu Q.#, Wang R.#, Ghanam AR., Yan G., Miao W., Song X.*, 2016
Three-dimensional regulation of transcription., Cao J., Luo Z., Cheng Q., Xu Q., Zhang Y., Wang F., Wu Y., Song X.*, 2015
The nonhistone, N-terminal tail of an essential, chimeric H2A variant regulates mitotic H3-S10 dephosphorylation., Song X., Bowen J., Miao W., Liu Y., and Gorovsky MA.*, 2012
Promoter-associated noncoding RNA from the CCND1 promoter., Song X.#, Wang X.#, Arai S. and Kurokawa R.*, 2012
9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response., Harismendy O.#, Notani D.#, Song X., Rahim NG., Tanasa B., Heintzman N., Ren B., Fu XD., Topol EJ., Rosenfeld MG*, and Frazer KA*, 2011
The Long Arm of Long Noncoding RNAs: Roles as Sensors Regulating Gene Transcriptional Programs., Wang X.# and Song X.#, Glass CK., and Rosenfeld MG*, 2011
Induced ncRNAs allosterically modify RNA binding proteins in cis to inhibit transcription., Wang X., Arai S.%, Song X.%, Reichart D., Du K., Pascual G., Tempst P., Rosenfeld MG.#, Glass CK.#, and Kurokawa R.#, 2008
Phosphorylation of the SQ H2A.X motif is required for proper meiosis and mitosis in Tetrahymena thermophila., Song, X.#, Gjoneska E.#, Ren Q.#, Taverna SD., Allis C.D., and Gorovsky MA.*, 2007
Unphosphorylated H1 is enriched in a specific region of the promoter when CDC2 is down-regulated during starvation., Song X. and Gorovsky MA.*, 2007
A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila., Shang Y., Song X., Bowen J., Corstanje R., Gao Y., Gaertig J., and Gorovsky MA.*, 2002

3D Genome Transcriptional Regulation Brain Aging Lncrna Chromatin Interactions Meiosis Spermatogenesis Gene Expression Epigenetics Neurobiology

Miao Yu - Fudan University

Xingwang Li - Huazhong Agricultural University

Jiapai Yan - Huazhong Agricultural University

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