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Xing Yuhang
Life Science
University of Science and Technology of China
Anhui
Language: Chinese, English
Rna
Gene Transcription
Cancer
Noncoding Rna
Enhancer Rna
Mitosis
Transcription Factors
3D Genome
Chromatin
Epigenetics
Areas of Focus
- RNA-mediated gene transcription regulation in cancer cells
- Identification of key transcription factors during mitosis
- Relationship between 3D genome organization and gene transcription regulation
Work Experience
- 2018-2023 - Harvard Medical School - Postdoctoral Research
- 2023-Present - University of Science and Technology of China - Specially Appointed Professor
Academic Background & Achievements
- 2012 - Bachelor's Degree: Nanjing University
- 2018 - PhD: Shanghai Institute of Life Sciences, Chinese Academy of Sciences
- Published as first author in journals like Cell and Nature Biotechnology
Publications
- DisP-seq reveals the genome-wide functional organization of DNA-associated disordered proteins, Xing YH, Dong R, Lee L, Rengarajan S, Riggi N, Boulay G, Rivera MN, 2023
- Highly connected 3D chromatin networks established by an oncogenic fusion protein shape tumor cell identity, Rajendran S, Dong R, Lee L, Xing YH, Iyer S, 2023
- Condensates induced by transcription inhibition localize active chromatin to nucleoli, Yasuhara T, Xing YH, Bauer N, Lee L, Dong R, Yadav T, Soberman R, Rivera MN, Zou L, 2022
- EWSR1-ATF1 dependent 3D connectivity regulates oncogenic and differentiation programs in Clear Cell Sarcoma, Möller E, Praz V, Rajendran S, Dong R, Cauderay A, Xing YH, 2022
- lncRNA SLERT controls phase separation of FC/DFCs to facilitate Pol I transcription, Wu M, Xu G, Han C, Luan PF, Xing YH, Nan F, Yang LZ, Huang YK, Yang ZH, Shan L, Yang L, Liu JQ, Chen LL, 2021
- The chromatin landscape of primary synovial sarcoma organoids is linked to specific epigenetic mechanisms and dependencies, Boulay G, Cironi L, Garcia S.P, Rengarajan S, Xing YH, 2020
- Distinct processing of lncRNAs contributes to non-conserved functions in stem cells, Guo CJ, Ma XK, Xing YH, Zheng CC, Xu YF, Shan L, Zhang J, Wang SH, Wang YM, Carmichael GG, Yang L, Chen LL, 2020
- Nascent Pre-rRNA Sorting via Phase Separation Drives the Assembly of Dense Fibrillar Components in the Human Nucleolus, Yao RW, Xu G, Wang Y, Shan L, Luan PF, Wang Y, Wu M, Yang LZ, Xing YH, Yang L, Chen LL, 2019
- Processing and roles of snoRNA-ended long noncoding RNAs, Xing YH, Chen LL, 2018
- SLERT regulates DDX21-rings associated with Pol I transcription, Xing YH, Yao RW, Zhang Y, Guo CJ, Jiang S, Xv G, Dong R, Yang L, Chen LL, 2017
- Long Noncoding RNAs Stabilized by Small Nucleolar RNA-Protein (snoRNP) Ends, Xing YH, Chen LL, 2017
- Research progress of long noncoding RNA in China, Xing YH, Bai ZQ, Liu CX, Hu SB, Ruan MH, Chen LL, 2016
- CRISPR-Cas9-Mediated Genetic Screening in Mice with Haploid Embryonic Stem Cells Carrying a Guide RNA Library, Zhong CQ, Yin Q, Xie ZF, Bai MZ, Dong R, Tang W, Xing YH, 2015
- Circular intronic long noncoding RNAs, Zhang Y, Zhang XO, Chen T, Xiang JF, Yin QF, Xing YH, Zhu S, Yang L, Chen LL, 2013
- Remarkable difference of somatic mutation patterns between oncogenes and tumor suppressor genes, Liu HX, Xing YH, Yang SH, Tian DC, 2011
Awards
- Chinese Academy of Sciences Outstanding Doctoral Dissertation
- Chinese Academy of Sciences University Outstanding Graduate
- Chinese Academy of Sciences President's Special Award
