Areas of Focus
- Development and functional study of 3D genomic detection technologies
- Study of transcriptional regulation mechanisms
- RNA metabolism and its role in genomic functions
- Structure and function of extrachromosomal DNA in cancer
Work Experience
- 2018.9-2023.4 - University of California, San Diego, Department of Cellular and Molecular Medicine, Postdoctoral Researcher
- 2023.4-present - Southern University of Science and Technology, Department of Systems Biology, Assistant Professor
Academic Background & Achievements
- 2008-2012 Bachelor in Bioinformatics: Huazhong University of Science and Technology
- 2012-2018 PhD in Biology: Tsinghua University (Supervisor: Professor Qiwei Zhang)
Publications
- Pervasive chromatin-RNA binding protein interactions enable RNA-based regulation of transcription, Xiao, R.*, Chen, J.-Y.*, Liang, Z.*, Luo, D., Chen, G., Lu, Z.J., Chen, Y., Zhou, B., Li, H., and Du, X., 2019
- BL-Hi-C is an efficient and sensitive approach for capturing structural and regulatory chromatin interactions, Liang, Z., Li, G., Wang, Z., Djekidel, M.N., Li, Y., Qian, M.-P., Zhang, M.Q., and Chen, Y., 2017
- 3D genome encoded by LINE and SINE repeats, Liang, Z., and Fu, X.-D., 2021
- PRDM16 is a compact myocardium-enriched transcription factor required to maintain compact myocardial cardiomyocyte identity in left ventricle, Wu, T.*, Liang, Z.*, Zhang, Z., Liu, C., Zhang, L., Gu, Y., Peterson, K.L., Evans, S.M., Fu, X.-D., and Chen, J., 2022
- CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming, Song, Y.*, Liang, Z.*, Zhang, J.*, Hu, G.*, Wang, J., Li, Y., Guo, R., Dong, X., Babarinde, I.A., and Ping, W., 2022
- Reversing a model of Parkinson’s disease with in situ converted nigral neurons, Qian, H., Kang, X., Hu, J., Zhang, D., Liang, Z., Meng, F., Zhang, X., Xue, Y., Maimon, R., and Dowdy, S.F., 2020
- Initiation of parental genome reprogramming in fertilized oocyte by splicing kinase SRPK1-catalyzed protamine phosphorylation, Gou, L.-T., Lim, D.-H., Ma, W., Aubol, B.E., Hao, Y., Wang, X., Zhao, J., Liang, Z., Shao, C., and Zhang, X., 2020
- Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem CellsTargeting Transcription Machinery Potentiates Immunotherapy, Qiu, Z., Zhao, L., Shen, J.Z., Liang, Z., Wu, Q., Yang, K., Min, L., Gimple, R.C., Yang, Q., and Bhargava, S., 2022
- Mitochondrial Stress Induces an HRI-eIF2α Pathway Protective for Cardiomyopathy, Zhu, S., Nguyen, A., Pang, J., Zhao, J., Chen, Z.e., Liang, Z., Gu, Y., Huynh, H., Bao, Y., and Lee, S., 2022