Professor | Zhengyu Liang | Asia Growth Partners

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Name	Zhengyu Liang
Contact Information	liangzy@sustech.edu.cn
Language ability	Chinese, English
Province	Guangdong

Upload Avatar (500 x 500)

Name

Zhengyu Liang

Contact Information

liangzy@sustech.edu.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Southern University of Science and Technology
Faculty	Life Sciences
Academic Background & Achievements	2008-2012 Bachelor in Bioinformatics: Huazhong University of Science and Technology 2012-2018 PhD in Biology: Tsinghua University (Supervisor: Professor Qiwei Zhang)
Work Experience	2018.9-2023.4 - University of California, San Diego, Department of Cellular and Molecular Medicine, Postdoctoral Researcher 2023.4-present - Southern University of Science and Technology, Department of Systems Biology, Assistant Professor

University/Lab Affiliation and Title

Southern University of Science and Technology

Faculty

Life Sciences

Academic Background & Achievements

2008-2012 Bachelor in Bioinformatics: Huazhong University of Science and Technology
2012-2018 PhD in Biology: Tsinghua University (Supervisor: Professor Qiwei Zhang)

Work Experience

2018.9-2023.4 - University of California, San Diego, Department of Cellular and Molecular Medicine, Postdoctoral Researcher
2023.4-present - Southern University of Science and Technology, Department of Systems Biology, Assistant Professor

Areas of Focus	Development and functional study of 3D genomic detection technologies Study of transcriptional regulation mechanisms RNA metabolism and its role in genomic functions Structure and function of extrachromosomal DNA in cancer
Publications	Pervasive chromatin-RNA binding protein interactions enable RNA-based regulation of transcription, Xiao, R., Chen, J.-Y., Liang, Z., Luo, D., Chen, G., Lu, Z.J., Chen, Y., Zhou, B., Li, H., and Du, X., 2019 BL-Hi-C is an efficient and sensitive approach for capturing structural and regulatory chromatin interactions, Liang, Z., Li, G., Wang, Z., Djekidel, M.N., Li, Y., Qian, M.-P., Zhang, M.Q., and Chen, Y., 2017 3D genome encoded by LINE and SINE repeats, Liang, Z., and Fu, X.-D., 2021 PRDM16 is a compact myocardium-enriched transcription factor required to maintain compact myocardial cardiomyocyte identity in left ventricle, Wu, T., Liang, Z., Zhang, Z., Liu, C., Zhang, L., Gu, Y., Peterson, K.L., Evans, S.M., Fu, X.-D., and Chen, J., 2022 CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming, Song, Y., Liang, Z., Zhang, J., Hu, G.*, Wang, J., Li, Y., Guo, R., Dong, X., Babarinde, I.A., and Ping, W., 2022 Reversing a model of Parkinson’s disease with in situ converted nigral neurons, Qian, H., Kang, X., Hu, J., Zhang, D., Liang, Z., Meng, F., Zhang, X., Xue, Y., Maimon, R., and Dowdy, S.F., 2020 Initiation of parental genome reprogramming in fertilized oocyte by splicing kinase SRPK1-catalyzed protamine phosphorylation, Gou, L.-T., Lim, D.-H., Ma, W., Aubol, B.E., Hao, Y., Wang, X., Zhao, J., Liang, Z., Shao, C., and Zhang, X., 2020 Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem CellsTargeting Transcription Machinery Potentiates Immunotherapy, Qiu, Z., Zhao, L., Shen, J.Z., Liang, Z., Wu, Q., Yang, K., Min, L., Gimple, R.C., Yang, Q., and Bhargava, S., 2022 Mitochondrial Stress Induces an HRI-eIF2α Pathway Protective for Cardiomyopathy, Zhu, S., Nguyen, A., Pang, J., Zhao, J., Chen, Z.e., Liang, Z., Gu, Y., Huynh, H., Bao, Y., and Lee, S., 2022

Areas of Focus

Development and functional study of 3D genomic detection technologies
Study of transcriptional regulation mechanisms
RNA metabolism and its role in genomic functions
Structure and function of extrachromosomal DNA in cancer

Publications

Pervasive chromatin-RNA binding protein interactions enable RNA-based regulation of transcription, Xiao, R.*, Chen, J.-Y.*, Liang, Z.*, Luo, D., Chen, G., Lu, Z.J., Chen, Y., Zhou, B., Li, H., and Du, X., 2019
BL-Hi-C is an efficient and sensitive approach for capturing structural and regulatory chromatin interactions, Liang, Z., Li, G., Wang, Z., Djekidel, M.N., Li, Y., Qian, M.-P., Zhang, M.Q., and Chen, Y., 2017
3D genome encoded by LINE and SINE repeats, Liang, Z., and Fu, X.-D., 2021
PRDM16 is a compact myocardium-enriched transcription factor required to maintain compact myocardial cardiomyocyte identity in left ventricle, Wu, T.*, Liang, Z.*, Zhang, Z., Liu, C., Zhang, L., Gu, Y., Peterson, K.L., Evans, S.M., Fu, X.-D., and Chen, J., 2022
CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming, Song, Y.*, Liang, Z.*, Zhang, J.*, Hu, G.*, Wang, J., Li, Y., Guo, R., Dong, X., Babarinde, I.A., and Ping, W., 2022
Reversing a model of Parkinson’s disease with in situ converted nigral neurons, Qian, H., Kang, X., Hu, J., Zhang, D., Liang, Z., Meng, F., Zhang, X., Xue, Y., Maimon, R., and Dowdy, S.F., 2020
Initiation of parental genome reprogramming in fertilized oocyte by splicing kinase SRPK1-catalyzed protamine phosphorylation, Gou, L.-T., Lim, D.-H., Ma, W., Aubol, B.E., Hao, Y., Wang, X., Zhao, J., Liang, Z., Shao, C., and Zhang, X., 2020
Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem CellsTargeting Transcription Machinery Potentiates Immunotherapy, Qiu, Z., Zhao, L., Shen, J.Z., Liang, Z., Wu, Q., Yang, K., Min, L., Gimple, R.C., Yang, Q., and Bhargava, S., 2022
Mitochondrial Stress Induces an HRI-eIF2α Pathway Protective for Cardiomyopathy, Zhu, S., Nguyen, A., Pang, J., Zhao, J., Chen, Z.e., Liang, Z., Gu, Y., Huynh, H., Bao, Y., and Lee, S., 2022

Genomics 3D Genome Transcription Rna Cancer Extrachromosomal Dna Bioinformatics Molecular Biology Gene Regulation Chromatin

Xingwang Li - Huazhong Agricultural University

Jiapai Yan - Huazhong Agricultural University

Xing Yuhang - University of Science and Technology of China

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