Professor | Zheng Ji Shen | Asia Growth Partners

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Name	Zheng Ji Shen
Contact Information	jszheng@ustc.edu.cn
Language ability	Chinese, English
Province	Anhui

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Name

Zheng Ji Shen

Contact Information

jszheng@ustc.edu.cn

Language ability

Chinese, English

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Life Sciences
Academic Background & Achievements	2002-2006 Bachelor's Degree: University of Science and Technology of China 2006-2012 Doctorate: University of Science and Technology of China Published over 50 research papers as corresponding author in journals like J Am Chem Soc, Angew Chem Int Ed, Chem, Science Advance, Nature Protocols Recipient of the National Science Fund for Excellent Young Scholars
Work Experience	2012-2014 - Tsinghua University - Postdoctoral Researcher 2014-2016 - Hefei Institutes of Physical Science, Chinese Academy of Sciences - Associate Researcher 2016-2020 - University of Science and Technology of China - Researcher 2021-present - University of Science and Technology of China - Professor
Awards	National Science Fund for Excellent Young Scholars

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Life Sciences

Academic Background & Achievements

2002-2006 Bachelor's Degree: University of Science and Technology of China
2006-2012 Doctorate: University of Science and Technology of China
Published over 50 research papers as corresponding author in journals like J Am Chem Soc, Angew Chem Int Ed, Chem, Science Advance, Nature Protocols
Recipient of the National Science Fund for Excellent Young Scholars

Work Experience

2012-2014 - Tsinghua University - Postdoctoral Researcher
2014-2016 - Hefei Institutes of Physical Science, Chinese Academy of Sciences - Associate Researcher
2016-2020 - University of Science and Technology of China - Researcher
2021-present - University of Science and Technology of China - Professor

Awards

National Science Fund for Excellent Young Scholars

Areas of Focus	Protein Chemistry and Synthetic Biology
Publications	Mirror-image protein and peptide drug discovery through mirror-image phage display, Qi, Y.-K.; Zheng, J. S.; Liu, L., 2024 Enhanced Native Chemical Ligation by Peptide Conjugation in Trifluoroacetic Acid, Dong-Liang Huang; Wu-Chen Guo; Wei-Wei Shi; Yun-Pu Gao; Yong-Kang Zhou; Long-Jie Wang; Chen Wang; Tang, S.; Liu, L.; Zheng, J. S., 2024 An Enzyme-Cleavable Solubilizing-Tag Facilitates the Chemical Synthesis of Mirror-Image Proteins, Zheng, Y.; Zhang, B.; Shi, W. W.; Deng, X.; Wang, T. Y.; Han, D.; Ren, Y.; Yang, Z.; Zhou, Y. K.; Kuang, J.; Wang, Z.W.; Tang, S.; Zheng, J. S., 2024 L-Glycosidase-Cleavable Natural Glycans Facilitate the Chemical Synthesis of Correctly Folded Disulfide-Bonded D-Proteins, Shi, W. W.; Wang, T. Y.; Yang, Z. Y.; Ren, Y. X.; Han, D. Y.; Zheng, Y. P.; Deng, X. Y.; Tang, S.; Zheng, J. S., 2024 Backbone‐Installed Split Intein‐Assisted Ligation for the Chemical Synthesis of Mirror‐Image Proteins, Zhang, B.; Zheng, Y.; Chu, G.; Deng, X.; Wang, T.; Shi, W.; Zhou, Y.; Tang, S.; Zheng, J. S.; Liu, L., 2023 An improved installation of 2-hydroxy-4-methoxybenzyl (iHmb) method for chemical protein synthesis, Li, Y.; Wang, L.-J.; Zhou, Y.-K.; Liang, J.; Xiao, B.; Zheng, J. S., 2024 Chemical synthesis of a 28 kDa full-length PET degrading enzyme ICCG by the removable backbone modification strategy, Gao, Y.-P.; Sun, P.-F.; Guo, W.-C.; Zhou, Y.-K.; Zheng, J. S.; Tang, S., 2024 Chemically Synthetic D-Sortase Enables Enzymatic Ligation of D-Peptides, Ding, R. C.; Shi, W. W.; Zheng, J. S., 2023 Split Intein: a Versatile Tool for Traceless Peptide Segment Ligation, Han, D. Y.; Ren, Y. X.; Yang, Z. Y.; Huang, H.; Zheng, J. S., 2023 Total Chemical Synthesis of Correctly Folded Disulfide-Rich Proteins Using a Removable O-Linked beta-N-Acetylglucosamine Strategy, Shi, W. W.; Shi, C.; Wang, T. Y.; Li, Y. L.; Zhou, Y. K.; Zhang, X. H.; Bierer, D.; Zheng, J. S.; Liu, L., 2022 Chemical Synthesis of a Full-Length G-Protein-Coupled Receptor beta2-Adrenergic Receptor with Defined Modification Patterns at the C-Terminus, Li, Y.; Heng, J.; Sun, D.; Zhang, B.; Zhang, X.; Zheng, Y.; Shi, W. W.; Wang, T. Y.; Li, J. Y.; Sun, X.; Liu, X.; Zheng, J. S.; Kobilka, B. K.; Liu, L., 2021 Chemical protein synthesis-assisted high-throughput screening strategies for d-peptides in drug discovery, Li, Y.; Cao, X.; Tian, C.; Zheng, J. S., 2020 The New Salcylaldehyde S,S-Propanedithioacetal Ester Enables N-to-C Sequential Native Chemical Ligation and Ser/Thr Ligation for Chemical Protein Synthesis, Huang, D.-L.; Li, Y.; Liang, J.; Yu, L.; Xue, M.; Cao, X.-X.; Xiao, B.; Tian, C.-L.; Liu, L.; Zheng, J. S., 2020 Chemical Synthesis of Native S-palmitoylated Membrane Proteins through Reversible Backbone Modification Assisted Ser/Thr Ligation, Huang, D. L.; Montigny, C.; Zheng, Y.; Beswick, V.; Li, Y.; Cao, X. X.; Barbot, T.; Jaxel, C.; Liang, J.; Tian, C. L.; Jamin, N.; Zheng, J. S., 2020 Synthesis of disulfide surrogate peptides incorporating large-span surrogate bridges through a native chemical ligation-assisted diaminodiacid strategy, Qu, Q.; Gao, S.; Wu, F. M.; Zhang, M. G.; Li, Y; Zhang, L. H.; Donald Bierer; Tian, C. L.; Zheng, J. S.; Liu, L., 2020 Ligation of Soluble but Unreactive Peptide Segments in the Chemical Synthesis of Haemophilus Influenzae DNA Ligase, Zhang, B.; Deng, Q.; Zuo, C.; Yan, B.; Zuo, C.; Cao, X. X.; Zhu, T. F.; Zheng, J. S.; Liu, L., 2019 Recent advances in the chemical synthesis and semi-synthesis of poly-ubiquitin-based proteins and probes, Qi, Y.-K.; Si, Y.-Y.; Du, S.-S.; Liang, J.; Wang, K.-W.; Zheng, J. S., 2019 Channel activity of mirror-image M2 proton channel of influenza A virus is blocked by achiral or chiral inhibitors, Guo, Q. Y.; Zhang, L. H.; Zuo, C.; Huang, D. L.; Wang, Z. A.; Zheng, J. S.; Tian, C. L., 2019

Areas of Focus

Protein Chemistry and Synthetic Biology

Publications

Mirror-image protein and peptide drug discovery through mirror-image phage display, Qi, Y.-K.; Zheng, J. S.; Liu, L., 2024
Enhanced Native Chemical Ligation by Peptide Conjugation in Trifluoroacetic Acid, Dong-Liang Huang; Wu-Chen Guo; Wei-Wei Shi; Yun-Pu Gao; Yong-Kang Zhou; Long-Jie Wang; Chen Wang; Tang, S.; Liu, L.; Zheng, J. S., 2024
An Enzyme-Cleavable Solubilizing-Tag Facilitates the Chemical Synthesis of Mirror-Image Proteins, Zheng, Y.; Zhang, B.; Shi, W. W.; Deng, X.; Wang, T. Y.; Han, D.; Ren, Y.; Yang, Z.; Zhou, Y. K.; Kuang, J.; Wang, Z.W.; Tang, S.; Zheng, J. S., 2024
L-Glycosidase-Cleavable Natural Glycans Facilitate the Chemical Synthesis of Correctly Folded Disulfide-Bonded D-Proteins, Shi, W. W.; Wang, T. Y.; Yang, Z. Y.; Ren, Y. X.; Han, D. Y.; Zheng, Y. P.; Deng, X. Y.; Tang, S.; Zheng, J. S., 2024
Backbone‐Installed Split Intein‐Assisted Ligation for the Chemical Synthesis of Mirror‐Image Proteins, Zhang, B.; Zheng, Y.; Chu, G.; Deng, X.; Wang, T.; Shi, W.; Zhou, Y.; Tang, S.; Zheng, J. S.; Liu, L., 2023
An improved installation of 2-hydroxy-4-methoxybenzyl (iHmb) method for chemical protein synthesis, Li, Y.; Wang, L.-J.; Zhou, Y.-K.; Liang, J.; Xiao, B.; Zheng, J. S., 2024
Chemical synthesis of a 28 kDa full-length PET degrading enzyme ICCG by the removable backbone modification strategy, Gao, Y.-P.; Sun, P.-F.; Guo, W.-C.; Zhou, Y.-K.; Zheng, J. S.; Tang, S., 2024
Chemically Synthetic D-Sortase Enables Enzymatic Ligation of D-Peptides, Ding, R. C.; Shi, W. W.; Zheng, J. S., 2023
Split Intein: a Versatile Tool for Traceless Peptide Segment Ligation, Han, D. Y.; Ren, Y. X.; Yang, Z. Y.; Huang, H.; Zheng, J. S., 2023
Total Chemical Synthesis of Correctly Folded Disulfide-Rich Proteins Using a Removable O-Linked beta-N-Acetylglucosamine Strategy, Shi, W. W.; Shi, C.; Wang, T. Y.; Li, Y. L.; Zhou, Y. K.; Zhang, X. H.; Bierer, D.; Zheng, J. S.; Liu, L., 2022
Chemical Synthesis of a Full-Length G-Protein-Coupled Receptor beta2-Adrenergic Receptor with Defined Modification Patterns at the C-Terminus, Li, Y.; Heng, J.; Sun, D.; Zhang, B.; Zhang, X.; Zheng, Y.; Shi, W. W.; Wang, T. Y.; Li, J. Y.; Sun, X.; Liu, X.; Zheng, J. S.; Kobilka, B. K.; Liu, L., 2021
Chemical protein synthesis-assisted high-throughput screening strategies for d-peptides in drug discovery, Li, Y.; Cao, X.; Tian, C.; Zheng, J. S., 2020
The New Salcylaldehyde S,S-Propanedithioacetal Ester Enables N-to-C Sequential Native Chemical Ligation and Ser/Thr Ligation for Chemical Protein Synthesis, Huang, D.-L.; Li, Y.; Liang, J.; Yu, L.; Xue, M.; Cao, X.-X.; Xiao, B.; Tian, C.-L.; Liu, L.; Zheng, J. S., 2020
Chemical Synthesis of Native S-palmitoylated Membrane Proteins through Reversible Backbone Modification Assisted Ser/Thr Ligation, Huang, D. L.; Montigny, C.; Zheng, Y.; Beswick, V.; Li, Y.; Cao, X. X.; Barbot, T.; Jaxel, C.; Liang, J.; Tian, C. L.; Jamin, N.; Zheng, J. S., 2020
Synthesis of disulfide surrogate peptides incorporating large-span surrogate bridges through a native chemical ligation-assisted diaminodiacid strategy, Qu, Q.; Gao, S.; Wu, F. M.; Zhang, M. G.; Li, Y; Zhang, L. H.; Donald Bierer; Tian, C. L.; Zheng, J. S.; Liu, L., 2020
Ligation of Soluble but Unreactive Peptide Segments in the Chemical Synthesis of Haemophilus Influenzae DNA Ligase, Zhang, B.; Deng, Q.; Zuo, C.; Yan, B.; Zuo, C.; Cao, X. X.; Zhu, T. F.; Zheng, J. S.; Liu, L., 2019
Recent advances in the chemical synthesis and semi-synthesis of poly-ubiquitin-based proteins and probes, Qi, Y.-K.; Si, Y.-Y.; Du, S.-S.; Liang, J.; Wang, K.-W.; Zheng, J. S., 2019
Channel activity of mirror-image M2 proton channel of influenza A virus is blocked by achiral or chiral inhibitors, Guo, Q. Y.; Zhang, L. H.; Zuo, C.; Huang, D. L.; Wang, Z. A.; Zheng, J. S.; Tian, C. L., 2019

Protein Chemistry Synthetic Biology Bioorthogonal Reactions Protein Modification Functional Regulation Custom Proteins Antibody Development Cellular Drugs Enzyme Evolution Ai In Biology

Hu Jiazhi - Peking University

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