Professor | Hu Jiazhi | Asia Growth Partners

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Name	Hu Jiazhi
Contact Information	hujz (AT) pku.edu.cn
Language ability	Chinese, English
Province	Beijing

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Name

Hu Jiazhi

Contact Information

hujz (AT) pku.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Life Sciences
Academic Background & Achievements	2006 Bachelor: Peking University 2012 PhD: Peking University
Work Experience	2016 - Present: Researcher at Peking University 2012 - 2016: Postdoctoral Researcher at Harvard Medical School and Boston Children's Hospital
Awards	Outstanding Young Award, 2022 Teaching Excellence Award, 2021 Zheng Chang Teaching Award, 2021 Qiushi Outstanding Young Scholar, 2018 Green Leaf Biomedicine Outstanding Young, 2018 Bayer Scholar, 2018 Yifang Scholar, 2017 Harvard Chinese Life Science Research Award, 2016 American Cancer Research Center Postdoctoral Scholarship, 2014 Wu Rui Scholarship, 2012 Beijing Outstanding Graduate, 2012 Peking University Outstanding Graduate, 2012 Peking University Outstanding Thesis Award, 2012

University/Lab Affiliation and Title

Peking University

Faculty

Life Sciences

Academic Background & Achievements

2006 Bachelor: Peking University
2012 PhD: Peking University

Work Experience

2016 - Present: Researcher at Peking University
2012 - 2016: Postdoctoral Researcher at Harvard Medical School and Boston Children's Hospital

Awards

Outstanding Young Award, 2022
Teaching Excellence Award, 2021
Zheng Chang Teaching Award, 2021
Qiushi Outstanding Young Scholar, 2018
Green Leaf Biomedicine Outstanding Young, 2018
Bayer Scholar, 2018
Yifang Scholar, 2017
Harvard Chinese Life Science Research Award, 2016
American Cancer Research Center Postdoctoral Scholarship, 2014
Wu Rui Scholarship, 2012
Beijing Outstanding Graduate, 2012
Peking University Outstanding Graduate, 2012
Peking University Outstanding Thesis Award, 2012

Areas of Focus	Study of DNA replication, damage, and metabolism in mammalian chromatin environments Research on lymphocyte function changes over time and across different tissues Exploration of antibody development and maturation using synthetic biology
Publications	Fork coupling directs DNA replication elongation and termination, Liu Y, Zhangding Z, Liu X, Gan T, Ai C, Wu J, Liang H, Chen M, Guo Y, Lu R, Jiang Y, Ji X, Gao N, Kong DC, Li Q & Hu J, 2024 Cohesin maintains replication timing to suppress DNA damage on cancer genes, Wu J, Liu Y, Zhangding Z, Liu X, Ai C, Gan T, Liang H, Guo Y, Chen M, Liu Y, Yin J, Zhang W & Hu J, 2023 Safeguarding genome integrity during gene-editing therapy of age-related macular degeneration, Yin J, Fang K, Gao Y, Ou L, Yuan S, Xin C, Wu W, Wu W-W, Hong J, Yang H & Hu J, 2022 Engineering of efficiency enhanced Cas9 and base editors with improved gene therapy efficacies, Yin S, Zhang M, Liu Y, Sun X, Chen X, Yang L, Huo Y, Yang J, Zhang X, Han H, Zhang J, Li G, Xiao M, Guan Y, Liu M, Hu J, Wang L & Li D, 2022 CRISPR/Cas9-induced structural variations expand in T lymphocytes in vivo, Wu J, Zou Ziye, Liu Y, Liu X, Zhangding Z, Xu M & Hu J, 2022 Comprehensive assessment of miniature CRISPR-Cas12f nucleases for gene disruption, Xin C, Yin J, Yuan S, Ou L, Liu M, Zhang W & Hu J, 2022 Long-term correction of haemophilia B through CRISPR/Cas9 induced homology-independent targeted integration, Chen X, Niu X, Liu Y, Zheng R, Yang L, Lu J, Yin S, Wei Y, Pan J, Sayed A, Ma X, Liu M, Jing F, Liu M, Hu J, Wang L & Li D, 2022 The origin of unwanted editing byproducts in gene editing, Yin J & Hu J, 2022 C-terminal deletion-induced condensation sequesters AID from IgH targets in immunodeficiency, Xie X, Gan T, Rao B, Zhang W, Panchakshari RA, Yang D, Ji X, Cao Y, Alt FW, Meng F-L & Hu J, 2022 Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing, Yin J, Lu R, Xin C, Wang Y, Ling X, Li D, Zhang W, Liu M, Xie W, Kong L, Si W, Wei P, Xiao B, LEE HY, Liu T & Hu J, 2022 PEM-seq comprehensively quantifies DNA repair outcomes during gene-editing and DSB repair, Liu Y, Yin J, Gan T, Liu M, Xin C, Zhang W & Hu J, 2022 RAG2 abolishes RAG1 aggregation to facilitate V(D)J recombination, Gan T, Wang Y, Schatz DG & Hu J, 2021 Global detection of DNA repair outcomes induced by CRISPR-Cas9, Liu M, Zhang W, Xin C, Yin J, Shang Y, Ai C, Li J, Meng F-L & Hu J, 2021 In-depth assessment of the PAM compatibility and editing activities of Cas9 variants, Zhang W, Yin J, Zhang-Ding Z, Xin C, Liu M, Wang Y, Ai C & Hu J, 2021 Transcription shapes DNA replication initiation to preserve genome integrity, Liu Y, Ai C, Gan T, Wu J, Jiang Y, Liu X, Lu R, Gao N, Li Q, Ji X & Hu J, 2021 Optimizing genome editing strategy by primer-extension-mediated sequencing, Yin J, Liu M, Liu Y, Wu J, Gan T, Zhang W, Li Y, Zhou Y & Hu J, 2019 CRISPR/Cas9-mediated targeted chromosome elimination, Zuo E, Huo X, Yao X, Hu X, Sun Y, Yin J, He B, Wang X, Shi L, Ping J, Wei Y, Ying W, Wei W, Liu W, Tang C, Li Y, Hu J & Yang H, 2017 A highly sensitive and unbiased approach for elucidating antibody repertoires, Lin SG, Ba Z, Du Z, Zhang Y, Hu J & Alt FW, 2016 Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing, Hu J, Meyers RM, Dong J, Panchakshari RA, Alt FW & Frock RL, 2016 Chromosomal loop domains direct the recombination of antigen receptor genes, Hu J, Zhang Y, Zhao L, Frock RL, Du Z, Meyers RM, Meng F-L, Schatz DG & Alt FW, 2015 Mechanisms of recurrent chromosomal translocations, Frock RL, Hu J & Alt FW, 2015 Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases, Frock RL, Hu J, Meyers RM, Ho Y-J, Kii E & Alt FW, 2015 Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes, Hu J, Tepsuporn S, Meyers RM, Gostissa M & Alt FW, 2014 Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice, Tepsuporn S, Hu J, Gostissa M & Alt FW, 2014 The intra-S phase checkpoint pathway targets Dna2 to prevent stalled replication forks from reversing, Hu J, Sun L, Shen F, Chen Y, Hua Y, Liu Y, Zhang M, Hu Y, Wang Q, Xu W, Sun F, Ji J, Murray JM, Carr AM & Kong D, 2012

Areas of Focus

Study of DNA replication, damage, and metabolism in mammalian chromatin environments
Research on lymphocyte function changes over time and across different tissues
Exploration of antibody development and maturation using synthetic biology

Publications

Fork coupling directs DNA replication elongation and termination, Liu Y, Zhangding Z, Liu X, Gan T, Ai C, Wu J, Liang H, Chen M, Guo Y, Lu R, Jiang Y, Ji X, Gao N, Kong DC, Li Q & Hu J, 2024
Cohesin maintains replication timing to suppress DNA damage on cancer genes, Wu J, Liu Y, Zhangding Z, Liu X, Ai C, Gan T, Liang H, Guo Y, Chen M, Liu Y, Yin J, Zhang W & Hu J, 2023
Safeguarding genome integrity during gene-editing therapy of age-related macular degeneration, Yin J, Fang K, Gao Y, Ou L, Yuan S, Xin C, Wu W, Wu W-W, Hong J, Yang H & Hu J, 2022
Engineering of efficiency enhanced Cas9 and base editors with improved gene therapy efficacies, Yin S, Zhang M, Liu Y, Sun X, Chen X, Yang L, Huo Y, Yang J, Zhang X, Han H, Zhang J, Li G, Xiao M, Guan Y, Liu M, Hu J, Wang L & Li D, 2022
CRISPR/Cas9-induced structural variations expand in T lymphocytes in vivo, Wu J, Zou Ziye, Liu Y, Liu X, Zhangding Z, Xu M & Hu J, 2022
Comprehensive assessment of miniature CRISPR-Cas12f nucleases for gene disruption, Xin C, Yin J, Yuan S, Ou L, Liu M, Zhang W & Hu J, 2022
Long-term correction of haemophilia B through CRISPR/Cas9 induced homology-independent targeted integration, Chen X, Niu X, Liu Y, Zheng R, Yang L, Lu J, Yin S, Wei Y, Pan J, Sayed A, Ma X, Liu M, Jing F, Liu M, Hu J, Wang L & Li D, 2022
The origin of unwanted editing byproducts in gene editing, Yin J & Hu J, 2022
C-terminal deletion-induced condensation sequesters AID from IgH targets in immunodeficiency, Xie X, Gan T, Rao B, Zhang W, Panchakshari RA, Yang D, Ji X, Cao Y, Alt FW, Meng F-L & Hu J, 2022
Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing, Yin J, Lu R, Xin C, Wang Y, Ling X, Li D, Zhang W, Liu M, Xie W, Kong L, Si W, Wei P, Xiao B, LEE HY, Liu T & Hu J, 2022
PEM-seq comprehensively quantifies DNA repair outcomes during gene-editing and DSB repair, Liu Y, Yin J, Gan T, Liu M, Xin C, Zhang W & Hu J, 2022
RAG2 abolishes RAG1 aggregation to facilitate V(D)J recombination, Gan T, Wang Y, Schatz DG & Hu J, 2021
Global detection of DNA repair outcomes induced by CRISPR-Cas9, Liu M, Zhang W, Xin C, Yin J, Shang Y, Ai C, Li J, Meng F-L & Hu J, 2021
In-depth assessment of the PAM compatibility and editing activities of Cas9 variants, Zhang W, Yin J, Zhang-Ding Z, Xin C, Liu M, Wang Y, Ai C & Hu J, 2021
Transcription shapes DNA replication initiation to preserve genome integrity, Liu Y, Ai C, Gan T, Wu J, Jiang Y, Liu X, Lu R, Gao N, Li Q, Ji X & Hu J, 2021
Optimizing genome editing strategy by primer-extension-mediated sequencing, Yin J, Liu M, Liu Y, Wu J, Gan T, Zhang W, Li Y, Zhou Y & Hu J, 2019
CRISPR/Cas9-mediated targeted chromosome elimination, Zuo E, Huo X, Yao X, Hu X, Sun Y, Yin J, He B, Wang X, Shi L, Ping J, Wei Y, Ying W, Wei W, Liu W, Tang C, Li Y, Hu J & Yang H, 2017
A highly sensitive and unbiased approach for elucidating antibody repertoires, Lin SG, Ba Z, Du Z, Zhang Y, Hu J & Alt FW, 2016
Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing, Hu J, Meyers RM, Dong J, Panchakshari RA, Alt FW & Frock RL, 2016
Chromosomal loop domains direct the recombination of antigen receptor genes, Hu J, Zhang Y, Zhao L, Frock RL, Du Z, Meyers RM, Meng F-L, Schatz DG & Alt FW, 2015
Mechanisms of recurrent chromosomal translocations, Frock RL, Hu J & Alt FW, 2015
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases, Frock RL, Hu J, Meyers RM, Ho Y-J, Kii E & Alt FW, 2015
Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes, Hu J, Tepsuporn S, Meyers RM, Gostissa M & Alt FW, 2014
Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice, Tepsuporn S, Hu J, Gostissa M & Alt FW, 2014
The intra-S phase checkpoint pathway targets Dna2 to prevent stalled replication forks from reversing, Hu J, Sun L, Shen F, Chen Y, Hua Y, Liu Y, Zhang M, Hu Y, Wang Q, Xu W, Sun F, Ji J, Murray JM, Carr AM & Kong D, 2012

Dna Replication Dna Damage Dna Metabolism Chromatin Genome Stability Cancer Lymphocyte Function Tissue-Specific Changes Antibody Development Synthetic Biology

Zheng Ji Shen - University of Science and Technology of China

Zhang He - Tongji University

Yudong Cai - Shanghai University

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