Professor | Rongbin Zhou | Asia Growth Partners

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Name	Rongbin Zhou
Contact Information	zrb1980@ustc.edu.cn
Language ability	English, Chinese
Province	Anhui

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Name

Rongbin Zhou

Contact Information

zrb1980@ustc.edu.cn

Language ability

English, Chinese

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Basic Medical Sciences
Academic Background & Achievements	Identified new danger signal sensing receptors MC5R, GPR34 and revealed their mechanisms in tumor immune suppression and tissue damage repair. Discovered the role of NLRP3 in sterile inflammation in chronic diseases like type 2 diabetes and Parkinson's. Developed candidate drugs targeting danger signal sensing receptors.
Awards	National Natural Science Second Prize: First Contributor National Innovation Award Tan Jiazhen Life Science Innovation Award China Outstanding Young Scientist Award China Youth Science and Technology Award

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Basic Medical Sciences

Academic Background & Achievements

Identified new danger signal sensing receptors MC5R, GPR34 and revealed their mechanisms in tumor immune suppression and tissue damage repair.
Discovered the role of NLRP3 in sterile inflammation in chronic diseases like type 2 diabetes and Parkinson's.
Developed candidate drugs targeting danger signal sensing receptors.

Awards

National Natural Science Second Prize: First Contributor
National Innovation Award
Tan Jiazhen Life Science Innovation Award
China Outstanding Young Scientist Award
China Youth Science and Technology Award

Areas of Focus	Danger signal recognition and sensing mechanisms in sterile inflammation Neural and metabolic regulation mechanisms in sterile inflammation Drug discovery targeting sterile inflammation and danger signal sensing receptors
Publications	GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity., Yan J, Zhang C, Xu Y, Huang Z, Ye Q, Qian X, Zhu L, Huang G, Wang X, Jiang W, Zhou R., 2024 DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways., Huang Y, Jiang W, Zhou R., 2024 DAMPs and DAMP-sensing receptors in inflammation and diseases., Ma M, Jiang W, Zhou R., 2024 Cytosolic transfer of circulating LPS by EVs., Huang Y, Zhou R., 2023 Pituitary hormone α-MSH promotes tumor-induced myelopoiesis and immunosuppression., Xu Y, Yan J, Tao Y, Qian X, Zhang C, Yin L, Gu P, Liu Y, Pan Y, Tang R, Jiang W, Zhou R., 2022 GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair., Wang X, Cai J, Lin B, Ma M, Tao Y, Zhou Y, Bai L, Jiang W, Zhou R., 2021 Myeloid PTEN promotes chemotherapy-induced NLRP3 inflammasome activation and antitumor immunity., Huang Y, Wang H, Hao Y, Lin H, Dong M, Ye J, Song L, Wang Y, Li Q, Shan B, Jiang Y, Li H, Shao Z, Kroemer G, Zhang H, Bai L, Jin T, Wang C, Ma Y, Cai Y, Ding C, Liu S, Pan Y, Jiang W, Zhou R., 2020 DAMP-sensing receptors in sterile inflammation and inflammatory diseases., Gong T, Liu L, Jiang W, Zhou R., 2020 ApoC3: an 'alarmin' triggering sterile inflammation., Gong T, Zhou R., 2020 Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling., Liu L, Gong T, Tao W, Lin B, Li C, Zheng X, Zhu S, Jiang W, Zhou R., 2019 Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome., Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z, Zhou R., 2015 RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway., Wang X, Jiang W, Yan Y, Gong T, Han J, Tian Z, Zhou R., 2014 ω-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation., Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G, Tian Z, Tschopp J, Zhou R., 2013

Areas of Focus

Danger signal recognition and sensing mechanisms in sterile inflammation
Neural and metabolic regulation mechanisms in sterile inflammation
Drug discovery targeting sterile inflammation and danger signal sensing receptors

Publications

GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity., Yan J, Zhang C, Xu Y, Huang Z, Ye Q, Qian X, Zhu L, Huang G, Wang X, Jiang W, Zhou R., 2024
DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways., Huang Y, Jiang W, Zhou R., 2024
DAMPs and DAMP-sensing receptors in inflammation and diseases., Ma M, Jiang W, Zhou R., 2024
Cytosolic transfer of circulating LPS by EVs., Huang Y, Zhou R., 2023
Pituitary hormone α-MSH promotes tumor-induced myelopoiesis and immunosuppression., Xu Y, Yan J, Tao Y, Qian X, Zhang C, Yin L, Gu P, Liu Y, Pan Y, Tang R, Jiang W, Zhou R., 2022
GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair., Wang X, Cai J, Lin B, Ma M, Tao Y, Zhou Y, Bai L, Jiang W, Zhou R., 2021
Myeloid PTEN promotes chemotherapy-induced NLRP3 inflammasome activation and antitumor immunity., Huang Y, Wang H, Hao Y, Lin H, Dong M, Ye J, Song L, Wang Y, Li Q, Shan B, Jiang Y, Li H, Shao Z, Kroemer G, Zhang H, Bai L, Jin T, Wang C, Ma Y, Cai Y, Ding C, Liu S, Pan Y, Jiang W, Zhou R., 2020
DAMP-sensing receptors in sterile inflammation and inflammatory diseases., Gong T, Liu L, Jiang W, Zhou R., 2020
ApoC3: an 'alarmin' triggering sterile inflammation., Gong T, Zhou R., 2020
Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling., Liu L, Gong T, Tao W, Lin B, Li C, Zheng X, Zhu S, Jiang W, Zhou R., 2019
Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome., Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z, Zhou R., 2015
RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway., Wang X, Jiang W, Yan Y, Gong T, Han J, Tian Z, Zhou R., 2014
ω-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation., Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G, Tian Z, Tschopp J, Zhou R., 2013

Danger Signals Sensing Receptors Sterile Inflammation Immune Suppression Tissue Repair Nlrp3 Chronic Diseases Drug Discovery Metabolic Regulation Neural Regulation

Bai Li - University of Science and Technology of China

Tie Lu - Peking University

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