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Rongbin Zhou
Basic Medical Sciences
University of Science and Technology of China
Anhui
Language: English, Chinese
Danger Signals
Sensing Receptors
Sterile Inflammation
Immune Suppression
Tissue Repair
Nlrp3
Chronic Diseases
Drug Discovery
Metabolic Regulation
Neural Regulation
Areas of Focus
- Danger signal recognition and sensing mechanisms in sterile inflammation
- Neural and metabolic regulation mechanisms in sterile inflammation
- Drug discovery targeting sterile inflammation and danger signal sensing receptors
Academic Background & Achievements
- Identified new danger signal sensing receptors MC5R, GPR34 and revealed their mechanisms in tumor immune suppression and tissue damage repair.
- Discovered the role of NLRP3 in sterile inflammation in chronic diseases like type 2 diabetes and Parkinson's.
- Developed candidate drugs targeting danger signal sensing receptors.
Publications
- GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity., Yan J, Zhang C, Xu Y, Huang Z, Ye Q, Qian X, Zhu L, Huang G, Wang X, Jiang W, Zhou R., 2024
- DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways., Huang Y, Jiang W, Zhou R., 2024
- DAMPs and DAMP-sensing receptors in inflammation and diseases., Ma M, Jiang W, Zhou R., 2024
- Cytosolic transfer of circulating LPS by EVs., Huang Y, Zhou R., 2023
- Pituitary hormone α-MSH promotes tumor-induced myelopoiesis and immunosuppression., Xu Y, Yan J, Tao Y, Qian X, Zhang C, Yin L, Gu P, Liu Y, Pan Y, Tang R, Jiang W, Zhou R., 2022
- GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair., Wang X, Cai J, Lin B, Ma M, Tao Y, Zhou Y, Bai L, Jiang W, Zhou R., 2021
- Myeloid PTEN promotes chemotherapy-induced NLRP3 inflammasome activation and antitumor immunity., Huang Y, Wang H, Hao Y, Lin H, Dong M, Ye J, Song L, Wang Y, Li Q, Shan B, Jiang Y, Li H, Shao Z, Kroemer G, Zhang H, Bai L, Jin T, Wang C, Ma Y, Cai Y, Ding C, Liu S, Pan Y, Jiang W, Zhou R., 2020
- DAMP-sensing receptors in sterile inflammation and inflammatory diseases., Gong T, Liu L, Jiang W, Zhou R., 2020
- ApoC3: an 'alarmin' triggering sterile inflammation., Gong T, Zhou R., 2020
- Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling., Liu L, Gong T, Tao W, Lin B, Li C, Zheng X, Zhu S, Jiang W, Zhou R., 2019
- Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome., Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z, Zhou R., 2015
- RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway., Wang X, Jiang W, Yan Y, Gong T, Han J, Tian Z, Zhou R., 2014
- ω-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation., Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G, Tian Z, Tschopp J, Zhou R., 2013
Awards
- National Natural Science Second Prize: First Contributor
- National Innovation Award
- Tan Jiazhen Life Science Innovation Award
- China Outstanding Young Scientist Award
- China Youth Science and Technology Award
