Professor | Yang Cao | Asia Growth Partners

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Name	Yang Cao
Contact Information	yangcao208@ustc.edu.cn
Language ability	English, Chinese
Province	Anhui

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Name

Yang Cao

Contact Information

yangcao208@ustc.edu.cn

Language ability

English, Chinese

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Basic Medical Sciences
Academic Background & Achievements	2015 - PhD: University of Science and Technology of China Selected for the National Overseas High-Level Talent Program
Work Experience	2015-2023 - Postdoctoral and Assistant Researcher: University of Washington, Yale University, University of California, Los Angeles 2023 April - Present: University of Science and Technology of China, Department of Life Sciences and Medicine
Awards	Selected for the National Overseas High-Level Talent Program

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Basic Medical Sciences

Academic Background & Achievements

2015 - PhD: University of Science and Technology of China
Selected for the National Overseas High-Level Talent Program

Work Experience

2015-2023 - Postdoctoral and Assistant Researcher: University of Washington, Yale University, University of California, Los Angeles
2023 April - Present: University of Science and Technology of China, Department of Life Sciences and Medicine

Awards

Selected for the National Overseas High-Level Talent Program

Areas of Focus	Cardiovascular metabolic diseases Organ interaction in heart failure Genetic mechanisms of cardiac diastolic function Liver metabolism and gut microbiota in cardiac function Role of mitochondrial function in cardiovascular metabolic diseases
Publications	Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure., Cao Y, Wang Y-C, Zhou Z, Pan C, Jiang L, Zhou Z, Meng Y, Charugundla S, Li T, Allayee H, Seldin MM, and Lusis AJ., 2022 Identification of DNA Damage Repair Enzyme Ascc2 as Causal for Heart Failure with Preserved Ejection Fraction (HFpEF)., Cao Y, Pan C, Wang Y-C, Zhou Z, Jedian V, Meng Y, Campbell G, Guardino K, Li C, Wang J, and Lusis AJ., 2022 Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction., Wang YC, Koay YC, Pan C, Zhou Z, Wilson Tang WH, Wilcox J, Li XS, Zagouras A, Marques F, Allayee H, Rey FE, Kaye DM, O'Sullivan JF, Hazen SL, Cao Y, and Lusis AJ., 2024 Sex Differences in Heart Mitochondria Regulate Diastolic Dysfunction., Cao Y, Vergnes L, Wang Y-C, Pan C, Krishnan KC, Moore TM, Rosa-Garrido M, Kimball TH, Zhou Z, Charugundla S, Rau CD, Seldin MM, Wang J, Vondriska TM, Wang Y, Reue K, and Lusis AJ., 2022 Activation of γ2-AMPK Suppresses Ribosome Biogenesis and Protects Against Myocardial Ischemia/Reperfusion Injury., Cao Y#, Bojjireddy N#, Kim M, Li T, Zhai P, Nagarajan N, Sadoshima J, Palmiter RD, Tian R., 2017 miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency., Cao Y#, Guo WT#, Tian S, He X, Wang XW, Liu X, Gu KL, Ma X, Huang D, Hu L, Cai Y, Zhang H, Wang Y, Gao P., 2015 Coagulation factor with potential for the treatment of heart failure., Cao Y, Lusis AJ., 2022 Role of gut microbe-derived metabolites in cardiometabolic diseases: Systems based approach., Cao Y#, Aquino-Martinez R#, Hutchison E#, Allayee H, Lusis AJ, and Rey FE., 2022 Heterogeneity of small intestinal immune and epithelial cells and their cellular response network to a western diet., Wang YC, Cao Y, Pan C, Zhou ZQ, Yang LL, Lusis AJ., 2023 Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury., Li T, Zhang Z, Kolwicz SC Jr, Abell L, Roe ND, Kim M, Zhou B, Cao Y, Ritterhoff J, Gu H, Raftery D, Sun H, Tian R., 2017 Parkin Regulates Adiposity by Coordinating Mitophagy with Mitochondrial Biogenesis in White Adipocytes., Moore T, Cheng L, Wolf D, Ngo J, Segawa M, Zhu X, Strumwasser A, Cao Y, Clifford B, Ma A, Scumpia P, Shirihai O, Vallim T, Laakso M, Lusis AJ, Hevener A, Zhenqi Zhou., 2022 Failed Power Plant Turns into Mass Murder: New Insight on Mitochondrial Cardiomyopathy., Lee CF, Cao Y, Tian R., 2018 Genetic Architecture of Heart Mitochondrial Proteome influencing Cardiac Hypertrophy., Krishnan KC, Hachem EJ, Keller MP, Patel SG, Carroll L, Vegas AD, Gyuricza IG, Light C, Cao Y, Pan C, Kaczor-Urbanowicz KE, Shravah V, Anum D, Pellegrini M, Lee CF, Seldin MM, Rosenthal NA, Churchill GA, Attie AD, Parker BL, James DE, and Lusis AJ., 2023

Areas of Focus

Cardiovascular metabolic diseases
Organ interaction in heart failure
Genetic mechanisms of cardiac diastolic function
Liver metabolism and gut microbiota in cardiac function
Role of mitochondrial function in cardiovascular metabolic diseases

Publications

Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure., Cao Y, Wang Y-C, Zhou Z, Pan C, Jiang L, Zhou Z, Meng Y, Charugundla S, Li T, Allayee H, Seldin MM, and Lusis AJ., 2022
Identification of DNA Damage Repair Enzyme Ascc2 as Causal for Heart Failure with Preserved Ejection Fraction (HFpEF)., Cao Y, Pan C, Wang Y-C, Zhou Z, Jedian V, Meng Y, Campbell G, Guardino K, Li C, Wang J, and Lusis AJ., 2022
Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction., Wang YC, Koay YC, Pan C, Zhou Z, Wilson Tang WH, Wilcox J, Li XS, Zagouras A, Marques F, Allayee H, Rey FE, Kaye DM, O'Sullivan JF, Hazen SL, Cao Y*, and Lusis AJ*., 2024
Sex Differences in Heart Mitochondria Regulate Diastolic Dysfunction., Cao Y, Vergnes L, Wang Y-C, Pan C, Krishnan KC, Moore TM, Rosa-Garrido M, Kimball TH, Zhou Z, Charugundla S, Rau CD, Seldin MM, Wang J, Vondriska TM, Wang Y, Reue K, and Lusis AJ., 2022
Activation of γ2-AMPK Suppresses Ribosome Biogenesis and Protects Against Myocardial Ischemia/Reperfusion Injury., Cao Y#, Bojjireddy N#, Kim M, Li T, Zhai P, Nagarajan N, Sadoshima J, Palmiter RD, Tian R., 2017
miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency., Cao Y#, Guo WT#, Tian S, He X, Wang XW, Liu X, Gu KL, Ma X, Huang D, Hu L, Cai Y, Zhang H, Wang Y, Gao P., 2015
Coagulation factor with potential for the treatment of heart failure., Cao Y*, Lusis AJ., 2022
Role of gut microbe-derived metabolites in cardiometabolic diseases: Systems based approach., Cao Y#, Aquino-Martinez R#, Hutchison E#, Allayee H, Lusis AJ*, and Rey FE., 2022
Heterogeneity of small intestinal immune and epithelial cells and their cellular response network to a western diet., Wang YC, Cao Y, Pan C, Zhou ZQ, Yang LL, Lusis AJ., 2023
Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury., Li T, Zhang Z, Kolwicz SC Jr, Abell L, Roe ND, Kim M, Zhou B, Cao Y, Ritterhoff J, Gu H, Raftery D, Sun H, Tian R., 2017
Parkin Regulates Adiposity by Coordinating Mitophagy with Mitochondrial Biogenesis in White Adipocytes., Moore T, Cheng L, Wolf D, Ngo J, Segawa M, Zhu X, Strumwasser A, Cao Y, Clifford B, Ma A, Scumpia P, Shirihai O, Vallim T, Laakso M, Lusis AJ, Hevener A, Zhenqi Zhou., 2022
Failed Power Plant Turns into Mass Murder: New Insight on Mitochondrial Cardiomyopathy., Lee CF, Cao Y, Tian R., 2018
Genetic Architecture of Heart Mitochondrial Proteome influencing Cardiac Hypertrophy., Krishnan KC, Hachem EJ, Keller MP, Patel SG, Carroll L, Vegas AD, Gyuricza IG, Light C, Cao Y, Pan C, Kaczor-Urbanowicz KE, Shravah V, Anum D, Pellegrini M, Lee CF, Seldin MM, Rosenthal NA, Churchill GA, Attie AD, Parker BL, James DE, and Lusis AJ., 2023

Cardiovascular Metabolism Heart Failure Genetics Molecular Biology Physiology Organ Interaction Liver Microbiota Mitochondria

Er Dan Dong - Peking University

Yan Zhang - Peking University

Wei Jin Zang - Xi'an Jiaotong University

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