Transcriptional and epigenetic regulation mechanisms in T lymphocytes during antiviral infection and cancer Pathogenesis of common autoimmune diseases and biological basis for drug development Mechanisms of early lineage differentiation of myeloid and lymphoid thymic T lymphocytes and their relation to major diseases like leukemia
TFH cells depend on Tcf1-intrinsic HDAC activity to suppress CTLA4 and guard B-cell help function, Fengyin Li*, Xin Zhao#, Yali Zhang, Peng Shao, Xiaoke Ma, William J. Paradee, Chengyu Liu, Jianmin Wang, and Hai-Hui Xue*, 2021
Prostaglandin E1 and Its Analog Misoprostol Inhibit Human CML Stem Cell Self-Renewal via EP4 Receptor Activation and Repression of AP-1, Fengyin Li, Bing He, Xiaoke Ma, Shuyang Yu, Rupali R. Bhave, Steven R. Lentz, Kai Tan, Monica L. Guzman, Chen Zhao*, Hai-Hui Xue*, 2017
Tcf1 and Lef1 transcription factors establish CD8+ T cell identity through intrinsic HDAC activity, Shaojun Xing#, Fengyin Li#, Zhouhao Zeng#, Yunjie Zhao, Shuyang Yu, Qiang Shan, Yalan Li, Farrah C Phillips, Peterson K Maina, Hank H Qi, Chengyu Liu, Jun Zhu, R Marshall Pope, Catherine A Musselman, Chen Zeng, Weiqun Peng*, Hai-Hui Xue*, 2016
Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf, Fengyin Li, Zhouhao Zeng, Shaojun Xing, Jodi A. Gullicksrud, Qiang Shan, Jinyong Choi, Vladimir P. Badovinac, Shane Crotty, Weiqun Peng & Hai-Hui Xue*, 2018
MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists, Cong Lv#, Fengyin Li#, Xiang Li#, Yuhua Tian#, Yue Zhang, Xiaole Sheng, Yongli Song, Qingyong Meng, Shukai Yuan, Liming Luan, Thomas Andl, XuFeng, Baowei Jiao, Mingang Xu, Maksim V. Plikus, Xing Dai, Christopher Lengner, Wei Cui, Fazheng Ren, Jianwei Shuai, Sarah E. Millar, Zhengquan Yu*, 2017
Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors, Shuyang Yu#, Fengyin Li#, Shaojun Xing, Tianyan Zhao, Weiqun Peng, Hai-Hui Xue*, 2016
Numb and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial identity, and support lactogenesis, Yue Zhang#, Fengyin Li#, Yongli Song, Xiaole Sheng, Kai Xiong, Lei Chen, Dequan Liu, Christopher Lengner, Lixiang Xue, Zhengquan Yu*, 2016
Cutting edge: Tcf1 instructs follicular helper cell differentiation by repressing blimp1 in response to acute viral infection, Peng Shao#, Fengyin Li#, Jinyong Wang, Xia Chen, Chenyu Liu and Hai-Hui Xue*, 2019
Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria, Rahul Vijay#, Jenna J Guthmiller#, Alexandria J Sturtz, Fionna A Surette, Kai J Rogers, Ramakrishna R Sompallae, Fengyin Li, Rosemary L Pope, Jo-Anne Chan, Fabian de Labastida Rivera, Dean Andrew, Lachlan Webb, Wendy J Maury, Hai-Hui Xue, Christian R Engwerda, James S McCarthy, Michelle J Boyle, Noah S Butler, 2020
β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells, Xin Zhao, Peng Shao, Kexin Gai, Fengyin Li, Qiang Shan, Hai-Hui Xue, 2020
The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage, Qiang Shan#, Zhouhao Zeng#, Shaojun Xing, Fengyin Li, Stacey M Hartwig, Jodi A Gullicksrud, Samarchith P Kurup, Natalija Van Braeckel-Budimir, Yao Su, Matthew D Martin, Steven M Varga, Ichiro Taniuchi, John T Harty, Weiqun Peng, Vladimir P Badovinac*, Hai-Hui Xue*, 2017
Differential Requirements for Tcf1 Long Isoforms in CD8+ and CD4+ T Cell Responses to Acute Viral Infection, Jodi A. Gullicksrud, Fengyin Li, Shaojun Xing, Zhouhao Zeng, Weiqun Peng, Vladimir P. Badovinac, John T. Harty, Hai-Hui Xue*, 2017
Stabilization of NF-KB-inducing kinase suppresses MLL-AF9–induced acute myeloid leukemia, Yan Xiu, Qianze Dong, Qingchang Li, Fengyin Li, Nick Borcherding, Weizhou Zhang, Brendan Boyce, Hai-hui Xue*, Chen Zhao*, 2018
Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity, Shaojun Xing, Peng Shao, Fengyin Li, Xudong Zhao, Wooseok Seo, Justin C. Wheat, Selvi Ramasamy, Jianfeng Wang, Xiang Li, Weiqun Peng, Shuyang Yu, Chengyu Liu, Ichiro Taniuchi, David A. Sweetser, Hai-Hui Xue*, 2018
TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow, Qi Yang, Fengyin Li, Christelle Harly, Shaojun Xing, Longyun Ye, Xuefeng Xia, Haikun Wang, Xinxin Wang, Shuyang Yu, Xinyuan Zhou, Maggie Cam, Hai-Hui Xue*, Avinash Bhandoola*, 2015
LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6, Youn Soo Choi#, Jodi A Gullicksrud#, Shaojun Xing, Zhouhao Zeng, Qiang Shan, Fengyin Li, Paul E Love, Weiqun Peng, Hai-Hui Xue*, Shane Crotty*, 2015
Keywords
T LymphocytesTranscriptional RegulationEpigeneticsAntiviralCancerAutoimmune DiseasesDrug DevelopmentThymic DifferentiationLeukemiaBiological Mechanisms
