Areas of Focus
- Immune regulation and immunotherapy of tumors
- Regulatory mechanisms of biological rhythms
- How neuroimmunity regulates the body's antiviral infection
Work Experience
- 2010-present - National Natural Science Foundation of China - Review Expert
Academic Background & Achievements
- Discovered that bioactive small molecule lysophosphatidic acid (LPA) in serum is a determinant factor in regulating cilia dynamics.
- Revealed the molecular mechanism of UV-induced DNA damage leading to G1/S checkpoint arrest.
Publications
- LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis., Hu HB, Song ZQ, Song GP, Li S, Tu HQ, Wu M, Zhang YC, Yuan JF, Li TT, Li PY, Xu YL, Shen XL, Han QY, Li AL, Zhou T, Chun J, Zhang XM, Li HY*., 2021
- CEP55 promotes cilia disassembly through stabilizing Aurora A kinase., Zhang YC, Bai YF, Yuan JF, Shen XL, Xu YL, Jian XX, Li S, Song ZQ, Hu HB, Li PY, Tu HQ, Han QY, Wang N, Li AL, Zhang XM, Wu M, Zhou T, Li HY*., 2021
- Rab7 regulates primary cilia disassembly through cilia excision., Wang G, Hu HB, Chang Y, Huang Y, Song ZQ, Zhou SB, Chen L, Zhang YC, Wu M, Tu HQ, Yuan JF, Wang N, Pan X, Li AL, Zhou T, Zhang XM, He K, Li HY*., 2019
- LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores., Wu M, Chang Y, Hu H, Mu R, Zhang Y, Qin X, Duan X, Li W, Tu H, Zhang W, Wang G, Han Q, Li A, Zhou T, Iwai K, Zhang X, Li H*., 2019
- Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis., Tu HQ, Qin XH, Liu ZB, Song ZQ, Hu HB, Zhang YC, Chang Y, Wu M, Huang Y, Bai YF, Wang G, Han QY, Li AL, Zhou T, Liu F, Zhang XM, Li HY*., 2018
- Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability., Gao YF, Li T, Chang Y, Wang YB, Zhang WN, Li WH, He K, Mu R, Zhen C, Man JH, Pan X, Li T, Chen L, Yu M, Liang B, Chen Y, Xia Q, Zhou T, Gong WL, Li AL, Li HY*, Zhang XM*., 2011
- Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells., Man JH, Liang B, Gu YX, Zhou T, Li AL, Li T, Jin BF, Bai B, Zhang HY, Zhang WN, Li WH, Gong WL, Li HY*, Zhang XM*., 2010
- Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1., Li HY#, Liu H, Wang CH, Zhang JY, Man JH, Gao YF, Zhang PJ, Li WH, Zhao J, Pan X, Zhou T, Gong WL, Li AL, Zhang XM., 2008
- Phosphorylation-triggered CUEDC2 degradation promotes UV-induced G1 arrest through APC/C(Cdh1) regulation., Zhang WN, Zhou J, Zhou T, Li AL, Wang N, Xu JJ, Chang Y, Man JH, Pan X, Li T, Li WH, Mu R, Liang B, Chen L, Jin BF, Xia Q, Gong WL, Zhang XM, Wang L, Li HY*., 2013
- Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor κB (NF-κB) signaling., Wang YB, Tan B, Mu R, Chang Y, Wu M, Tu HQ, Zhang YC, Guo SS, Qin XH, Li T, Li WH, Li AL, Zhang XM, Li HY*., 2015
Awards
- National Natural Science Award Second Prize (2008)
- Beijing Science and Technology Award First Prize (2012)
- National Outstanding Youth Science Fund Recipient (2013)
- Qiu Shi Outstanding Youth Award (2014)
- Shulan Young Medical Award (2014)
- China Youth Science and Technology Award (2015)
- National Ten Thousand Talents Program Leading Talent (2018)
