Professor | Huiyan Li | Asia Growth Partners

Name	Huiyan Li
Contact Information	hyli@ncba.ac.cn
Language ability	Chinese, English
Province	Beijing

Name

Huiyan Li

Contact Information

hyli@ncba.ac.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Fudan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	Discovered that bioactive small molecule lysophosphatidic acid (LPA) in serum is a determinant factor in regulating cilia dynamics. Revealed the molecular mechanism of UV-induced DNA damage leading to G1/S checkpoint arrest.
Work Experience	2010-present - National Natural Science Foundation of China - Review Expert
Awards	National Natural Science Award Second Prize (2008) Beijing Science and Technology Award First Prize (2012) National Outstanding Youth Science Fund Recipient (2013) Qiu Shi Outstanding Youth Award (2014) Shulan Young Medical Award (2014) China Youth Science and Technology Award (2015) National Ten Thousand Talents Program Leading Talent (2018)

University/Lab Affiliation and Title

Fudan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

Discovered that bioactive small molecule lysophosphatidic acid (LPA) in serum is a determinant factor in regulating cilia dynamics.
Revealed the molecular mechanism of UV-induced DNA damage leading to G1/S checkpoint arrest.

Work Experience

2010-present - National Natural Science Foundation of China - Review Expert

Awards

National Natural Science Award Second Prize (2008)
Beijing Science and Technology Award First Prize (2012)
National Outstanding Youth Science Fund Recipient (2013)
Qiu Shi Outstanding Youth Award (2014)
Shulan Young Medical Award (2014)
China Youth Science and Technology Award (2015)
National Ten Thousand Talents Program Leading Talent (2018)

Areas of Focus	Immune regulation and immunotherapy of tumors Regulatory mechanisms of biological rhythms How neuroimmunity regulates the body's antiviral infection
Publications	LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis., Hu HB, Song ZQ, Song GP, Li S, Tu HQ, Wu M, Zhang YC, Yuan JF, Li TT, Li PY, Xu YL, Shen XL, Han QY, Li AL, Zhou T, Chun J, Zhang XM, Li HY., 2021 CEP55 promotes cilia disassembly through stabilizing Aurora A kinase., Zhang YC, Bai YF, Yuan JF, Shen XL, Xu YL, Jian XX, Li S, Song ZQ, Hu HB, Li PY, Tu HQ, Han QY, Wang N, Li AL, Zhang XM, Wu M, Zhou T, Li HY., 2021 Rab7 regulates primary cilia disassembly through cilia excision., Wang G, Hu HB, Chang Y, Huang Y, Song ZQ, Zhou SB, Chen L, Zhang YC, Wu M, Tu HQ, Yuan JF, Wang N, Pan X, Li AL, Zhou T, Zhang XM, He K, Li HY., 2019 LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores., Wu M, Chang Y, Hu H, Mu R, Zhang Y, Qin X, Duan X, Li W, Tu H, Zhang W, Wang G, Han Q, Li A, Zhou T, Iwai K, Zhang X, Li H., 2019 Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis., Tu HQ, Qin XH, Liu ZB, Song ZQ, Hu HB, Zhang YC, Chang Y, Wu M, Huang Y, Bai YF, Wang G, Han QY, Li AL, Zhou T, Liu F, Zhang XM, Li HY., 2018 Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability., Gao YF, Li T, Chang Y, Wang YB, Zhang WN, Li WH, He K, Mu R, Zhen C, Man JH, Pan X, Li T, Chen L, Yu M, Liang B, Chen Y, Xia Q, Zhou T, Gong WL, Li AL, Li HY, Zhang XM., 2011 Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells., Man JH, Liang B, Gu YX, Zhou T, Li AL, Li T, Jin BF, Bai B, Zhang HY, Zhang WN, Li WH, Gong WL, Li HY, Zhang XM., 2010 Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1., Li HY#, Liu H, Wang CH, Zhang JY, Man JH, Gao YF, Zhang PJ, Li WH, Zhao J, Pan X, Zhou T, Gong WL, Li AL, Zhang XM., 2008 Phosphorylation-triggered CUEDC2 degradation promotes UV-induced G1 arrest through APC/C(Cdh1) regulation., Zhang WN, Zhou J, Zhou T, Li AL, Wang N, Xu JJ, Chang Y, Man JH, Pan X, Li T, Li WH, Mu R, Liang B, Chen L, Jin BF, Xia Q, Gong WL, Zhang XM, Wang L, Li HY., 2013 Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor κB (NF-κB) signaling., Wang YB, Tan B, Mu R, Chang Y, Wu M, Tu HQ, Zhang YC, Guo SS, Qin XH, Li T, Li WH, Li AL, Zhang XM, Li HY*., 2015

Areas of Focus

Immune regulation and immunotherapy of tumors
Regulatory mechanisms of biological rhythms
How neuroimmunity regulates the body's antiviral infection

Publications

LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis., Hu HB, Song ZQ, Song GP, Li S, Tu HQ, Wu M, Zhang YC, Yuan JF, Li TT, Li PY, Xu YL, Shen XL, Han QY, Li AL, Zhou T, Chun J, Zhang XM, Li HY*., 2021
CEP55 promotes cilia disassembly through stabilizing Aurora A kinase., Zhang YC, Bai YF, Yuan JF, Shen XL, Xu YL, Jian XX, Li S, Song ZQ, Hu HB, Li PY, Tu HQ, Han QY, Wang N, Li AL, Zhang XM, Wu M, Zhou T, Li HY*., 2021
Rab7 regulates primary cilia disassembly through cilia excision., Wang G, Hu HB, Chang Y, Huang Y, Song ZQ, Zhou SB, Chen L, Zhang YC, Wu M, Tu HQ, Yuan JF, Wang N, Pan X, Li AL, Zhou T, Zhang XM, He K, Li HY*., 2019
LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores., Wu M, Chang Y, Hu H, Mu R, Zhang Y, Qin X, Duan X, Li W, Tu H, Zhang W, Wang G, Han Q, Li A, Zhou T, Iwai K, Zhang X, Li H*., 2019
Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis., Tu HQ, Qin XH, Liu ZB, Song ZQ, Hu HB, Zhang YC, Chang Y, Wu M, Huang Y, Bai YF, Wang G, Han QY, Li AL, Zhou T, Liu F, Zhang XM, Li HY*., 2018
Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability., Gao YF, Li T, Chang Y, Wang YB, Zhang WN, Li WH, He K, Mu R, Zhen C, Man JH, Pan X, Li T, Chen L, Yu M, Liang B, Chen Y, Xia Q, Zhou T, Gong WL, Li AL, Li HY*, Zhang XM*., 2011
Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells., Man JH, Liang B, Gu YX, Zhou T, Li AL, Li T, Jin BF, Bai B, Zhang HY, Zhang WN, Li WH, Gong WL, Li HY*, Zhang XM*., 2010
Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1., Li HY#, Liu H, Wang CH, Zhang JY, Man JH, Gao YF, Zhang PJ, Li WH, Zhao J, Pan X, Zhou T, Gong WL, Li AL, Zhang XM., 2008
Phosphorylation-triggered CUEDC2 degradation promotes UV-induced G1 arrest through APC/C(Cdh1) regulation., Zhang WN, Zhou J, Zhou T, Li AL, Wang N, Xu JJ, Chang Y, Man JH, Pan X, Li T, Li WH, Mu R, Liang B, Chen L, Jin BF, Xia Q, Gong WL, Zhang XM, Wang L, Li HY*., 2013
Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor κB (NF-κB) signaling., Wang YB, Tan B, Mu R, Chang Y, Wu M, Tu HQ, Zhang YC, Guo SS, Qin XH, Li T, Li WH, Li AL, Zhang XM, Li HY*., 2015

Tumor Immune Regulation Immunotherapy Biological Rhythms Neuroimmunity Antiviral Infection Cancer Immune Response Therapy

Dan Lu - Peking University

Tao Li - Fudan University

Youhua Xie - Fudan University

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