Professor | Sun Rui | Asia Growth Partners

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Name	Sun Rui
Contact Information	sunr@ustc.edu.cn
Language ability	Chinese, English
Province	Anhui

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Name

Sun Rui

Contact Information

sunr@ustc.edu.cn

Language ability

Chinese, English

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Basic Medical Sciences
Academic Background & Achievements	1982 - Bachelor's Degree: Shanxi Medical University 2000 - Master's Degree: Bethune Medical University Achievement: Published over 50 SCI papers, 30 as first/corresponding author Achievement: Published over 100 academic papers in Chinese core journals
Work Experience	1995.8-1996.8 - NIH Cancer Institute - Collaborative Research in Natural Immunology 2001.3-2006.3 - NIH Alcoholic Disease Institute - Collaborative Research in Natural Immunology Position: Executive Deputy Director of Shandong Provincial Key Laboratory of Tumor Immunology and Medical Gene Engineering
Awards	1994: Fourth 'China Youth Science and Technology Award' 1998: Special Government Allowance from the State Council 2005: NIH Outstanding Researcher Award

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Basic Medical Sciences

Academic Background & Achievements

1982 - Bachelor's Degree: Shanxi Medical University
2000 - Master's Degree: Bethune Medical University
Achievement: Published over 50 SCI papers, 30 as first/corresponding author
Achievement: Published over 100 academic papers in Chinese core journals

Work Experience

1995.8-1996.8 - NIH Cancer Institute - Collaborative Research in Natural Immunology
2001.3-2006.3 - NIH Alcoholic Disease Institute - Collaborative Research in Natural Immunology
Position: Executive Deputy Director of Shandong Provincial Key Laboratory of Tumor Immunology and Medical Gene Engineering

Awards

1994: Fourth 'China Youth Science and Technology Award'
1998: Special Government Allowance from the State Council
2005: NIH Outstanding Researcher Award

Areas of Focus	Mechanisms of natural immune tolerance and immunopathology of the liver Negative regulation mechanisms of liver NK cells in liver regeneration and injury Molecular mechanisms of natural immune receptor recognition
Publications	Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice., Cui K, Yan G, Xu C, Chen Y, Wang J, Zhou R, Bai L, Lian Z, Wei H, Sun R, Tian Z., 2015 Tumor-released Galectin-3, a soluble inhibitory ligand of human NKp30, plays an important role in tumor escape from NK cell attack., Wang W, Guo H, Geng J, Zheng X, Wei H, Sun R, Tian Z., 2014 CD226 protein is involved in immune synapse formation and triggers Natural Killer (NK) cell activation via its first extracellular domain., Hou S, Ge K, Zheng X, Wei H, Sun R, Tian Z., 2014 TIGIT safeguards liver regeneration through regulating natural killer cell-hepatocyte crosstalk., Bi J, Zheng X, Chen Y, Wei H, Sun R, Tian Z., 2014 T-cell Ig and ITIM domain regulates natural killer cell activation in murine acute viral hepatitis., Bi J, Zhang Q, Liang D, Xiong L, Wei H, Sun R, Tian Z., 2014 Recombinant soluble CD226 protein directly inhibits cancer cell proliferation in vitro., Hou S, Zheng X, Wei H, Tian Z, Sun R., 2014 Efficient attenuation of NK cell-mediated liver injury through genetically manipulating multiple immunogenes by using a liver-directed vector., Geng J, Wang X, Wei H, Sun R, Tian Z., 2013 CRACC-CRACC interaction between Kupffer and NK cells contributes to poly I:C/D-GalN induced hepatitis., Li Y, Cao G, Zheng X, Wang J, Wei H, Tian Z, Sun R., 2013 Construction and application of a novel hepatocyte-directed vector to simultaneous knockdown and overexpression of multiple genes., Geng J, Wei H, Sun R, Tian Z., 2013 Characterization of human B cells in umbilical cord blood-transplanted NOD/SCID mice., Wang X, Qi Z, Wei H, Tian Z, Sun R., 2012 Preparation and functional identification of a monoclonal antibody against the recombinant soluble human NKp30 receptor., Wang H, Zheng X, Wei H, Tian Z, Sun R., 2011 Activation of natural killer cells inhibits liver regeneration in toxin-induced liver injury model in mice via tumor necrosis factor-alpha-dependent mechanism., Wei H, Wei H, Wang H, Tian Z, Sun R*., 2010

Areas of Focus

Mechanisms of natural immune tolerance and immunopathology of the liver
Negative regulation mechanisms of liver NK cells in liver regeneration and injury
Molecular mechanisms of natural immune receptor recognition

Publications

Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice., Cui K, Yan G, Xu C, Chen Y, Wang J, Zhou R, Bai L, Lian Z, Wei H, Sun R*, Tian Z*., 2015
Tumor-released Galectin-3, a soluble inhibitory ligand of human NKp30, plays an important role in tumor escape from NK cell attack., Wang W, Guo H, Geng J, Zheng X, Wei H, Sun R*, Tian Z*., 2014
CD226 protein is involved in immune synapse formation and triggers Natural Killer (NK) cell activation via its first extracellular domain., Hou S, Ge K, Zheng X, Wei H, Sun R*, Tian Z*., 2014
TIGIT safeguards liver regeneration through regulating natural killer cell-hepatocyte crosstalk., Bi J, Zheng X, Chen Y, Wei H, Sun R*, Tian Z*., 2014
T-cell Ig and ITIM domain regulates natural killer cell activation in murine acute viral hepatitis., Bi J, Zhang Q, Liang D, Xiong L, Wei H, Sun R*, Tian Z*., 2014
Recombinant soluble CD226 protein directly inhibits cancer cell proliferation in vitro., Hou S, Zheng X, Wei H, Tian Z, Sun R*., 2014
Efficient attenuation of NK cell-mediated liver injury through genetically manipulating multiple immunogenes by using a liver-directed vector., Geng J, Wang X, Wei H, Sun R*, Tian Z*., 2013
CRACC-CRACC interaction between Kupffer and NK cells contributes to poly I:C/D-GalN induced hepatitis., Li Y, Cao G, Zheng X, Wang J, Wei H, Tian Z, Sun R*., 2013
Construction and application of a novel hepatocyte-directed vector to simultaneous knockdown and overexpression of multiple genes., Geng J, Wei H, Sun R*, Tian Z*., 2013
Characterization of human B cells in umbilical cord blood-transplanted NOD/SCID mice., Wang X, Qi Z, Wei H, Tian Z, Sun R*., 2012
Preparation and functional identification of a monoclonal antibody against the recombinant soluble human NKp30 receptor., Wang H, Zheng X, Wei H, Tian Z, Sun R*., 2011
Activation of natural killer cells inhibits liver regeneration in toxin-induced liver injury model in mice via tumor necrosis factor-alpha-dependent mechanism., Wei H, Wei H, Wang H, Tian Z, Sun R*., 2010

Immune Tolerance Immunopathology Liver Nk Cells Regeneration Injury Receptor Recognition Molecular Mechanisms Natural Immunity Immune Regulation

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