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Sun Rui
Basic Medical Sciences
University of Science and Technology of China
Anhui
Language: Chinese, English
Immune Tolerance
Immunopathology
Liver
Nk Cells
Regeneration
Injury
Receptor Recognition
Molecular Mechanisms
Natural Immunity
Immune Regulation
Areas of Focus
- Mechanisms of natural immune tolerance and immunopathology of the liver
- Negative regulation mechanisms of liver NK cells in liver regeneration and injury
- Molecular mechanisms of natural immune receptor recognition
Work Experience
- 1995.8-1996.8 - NIH Cancer Institute - Collaborative Research in Natural Immunology
- 2001.3-2006.3 - NIH Alcoholic Disease Institute - Collaborative Research in Natural Immunology
- Position: Executive Deputy Director of Shandong Provincial Key Laboratory of Tumor Immunology and Medical Gene Engineering
Academic Background & Achievements
- 1982 - Bachelor's Degree: Shanxi Medical University
- 2000 - Master's Degree: Bethune Medical University
- Achievement: Published over 50 SCI papers, 30 as first/corresponding author
- Achievement: Published over 100 academic papers in Chinese core journals
Publications
- Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice., Cui K, Yan G, Xu C, Chen Y, Wang J, Zhou R, Bai L, Lian Z, Wei H, Sun R*, Tian Z*., 2015
- Tumor-released Galectin-3, a soluble inhibitory ligand of human NKp30, plays an important role in tumor escape from NK cell attack., Wang W, Guo H, Geng J, Zheng X, Wei H, Sun R*, Tian Z*., 2014
- CD226 protein is involved in immune synapse formation and triggers Natural Killer (NK) cell activation via its first extracellular domain., Hou S, Ge K, Zheng X, Wei H, Sun R*, Tian Z*., 2014
- TIGIT safeguards liver regeneration through regulating natural killer cell-hepatocyte crosstalk., Bi J, Zheng X, Chen Y, Wei H, Sun R*, Tian Z*., 2014
- T-cell Ig and ITIM domain regulates natural killer cell activation in murine acute viral hepatitis., Bi J, Zhang Q, Liang D, Xiong L, Wei H, Sun R*, Tian Z*., 2014
- Recombinant soluble CD226 protein directly inhibits cancer cell proliferation in vitro., Hou S, Zheng X, Wei H, Tian Z, Sun R*., 2014
- Efficient attenuation of NK cell-mediated liver injury through genetically manipulating multiple immunogenes by using a liver-directed vector., Geng J, Wang X, Wei H, Sun R*, Tian Z*., 2013
- CRACC-CRACC interaction between Kupffer and NK cells contributes to poly I:C/D-GalN induced hepatitis., Li Y, Cao G, Zheng X, Wang J, Wei H, Tian Z, Sun R*., 2013
- Construction and application of a novel hepatocyte-directed vector to simultaneous knockdown and overexpression of multiple genes., Geng J, Wei H, Sun R*, Tian Z*., 2013
- Characterization of human B cells in umbilical cord blood-transplanted NOD/SCID mice., Wang X, Qi Z, Wei H, Tian Z, Sun R*., 2012
- Preparation and functional identification of a monoclonal antibody against the recombinant soluble human NKp30 receptor., Wang H, Zheng X, Wei H, Tian Z, Sun R*., 2011
- Activation of natural killer cells inhibits liver regeneration in toxin-induced liver injury model in mice via tumor necrosis factor-alpha-dependent mechanism., Wei H, Wei H, Wang H, Tian Z, Sun R*., 2010
Awards
- 1994: Fourth 'China Youth Science and Technology Award'
- 1998: Special Government Allowance from the State Council
- 2005: NIH Outstanding Researcher Award
