Professor | Guochao Wei | Asia Growth Partners

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Name	Guochao Wei
Contact Information	weiguochao@hsc.pku.edu.cn
Language ability	Chinese, English, German
Province	Beijing

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Name

Guochao Wei

Contact Information

weiguochao@hsc.pku.edu.cn

Language ability

Chinese, English, German

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2013-2018 PhD in Virology: Heidelberg University, Germany 2005-2012 Bachelor + Master (Seven-year program) in Basic Medical Science: Harbin Medical University
Work Experience	2023-present: Assistant Professor/Researcher, Peking University 2018-2023: Postdoctoral Researcher, University of Colorado Anschutz 2012-2013: Teaching Assistant, Harbin Medical University

University/Lab Affiliation and Title

Peking University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2013-2018 PhD in Virology: Heidelberg University, Germany
2005-2012 Bachelor + Master (Seven-year program) in Basic Medical Science: Harbin Medical University

Work Experience

2023-present: Assistant Professor/Researcher, Peking University
2018-2023: Postdoctoral Researcher, University of Colorado Anschutz
2012-2013: Teaching Assistant, Harbin Medical University

Areas of Focus	Molecular mechanisms of HIV-host interactions Design and screening of novel long-acting anti-HIV drugs Establishment of HIV and other major infectious diseases model and exploration of their immune regulation mechanisms
Publications	Structural and mechanistic bases for a potent HIV-1 capsid inhibitor, Bester, S.M., Wei, G., Zhao, H., Adu-Ampratwum, D., Iqbal, N., Courouble, V.V., Francis, A.C., Annamalai, A.S., Singh, P.K., Shkriabai, N., Van Blerkom, P., Morrison, J., Poeschla, E.M., Engelman, A.N., Melikyan, G.B., Griffin, P.R., Fuchs, J.R., Asturias, F.J. #, Kvaratskhelia, M#., 2020 Sec24C is an HIV-1 host dependency factor crucial for virus replication, Rebensburg, S.V., Wei, G.*, Larue, R.C., Lindenberger, J., Francis, A.C., Annamalai, A.S., Morrison, J., Shkriabai, N., Huang, S.W., KewalRamani, V., Poeschla, E.M., Melikyan, G.B., Kvaratskhelia, M#., 2021 Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection, Wei, G., Iqbal, N., Courouble, V.V., Francis, A.C., Annamalai, A.S., Bester, S.M., Singh, P.K Huang, S.W., Shkriabai, N., Haney R., KewalRamani, V., Engelman, A.N, Melikyan, G.B., Griffin, P.R., Asturias, F.J, Kvaratskhelia, M. #, 2022 The chromatin binding domain, including the QPQRYG motif, of feline foamy virus Gag is required for viral DNA integration and nuclear accumulation of Gag and the viral genome, Wei, G., Kehl, T., Bao, Q., Benner, A., Lei, J., Lochelt, M. #, 2018 Structural basis of viral resistance to HIV-1 capsid inhibitor lenacapavir, Bester, S.M., Adu-Ampratwum, D., Annamalai, A.S., Wei, G., Haney R., Fuchs, J.R., Kvaratskhelia, M. #, 2022 The Unique, the Known, and the Unknown of Spumaretrovirus Assembly, Lindemann, D., Hutter, S., Wei, G., Lochelt, M. #, 2021 Replacement of feline foamy virus bet by feline immunodeficiency virus vif yields replicative virus with novel vaccine candidate potential, Ledesma-Feliciano, C., Hagen, S., Troyer, R., Zheng, X., Musselman, E., Slavkovic Lukic, D., Franke, A.M., Maeda, D., Zielonka, J., Munk, C., Wei, G., VandeWoude, S., Lochelt, M. #, 2018 Mutagenesis of N-terminal residues of feline foamy virus Gag reveals entirely distinct functions during capsid formation, particle assembly, Gag processing and budding, Liu Y, Betts MJ, Lei J, Wei G, Bao Q, Kehl T, Russell RB, Lochelt M#, 2016 Replication-Competent Foamy Virus Vaccine Vectors as Novel Epitope Scaffolds for Immunotherapy, Lei J, Osen W, Gardyan A, Hotz-Wagenblatt A, Wei G, Gissmann L, Eichmuller S, Lochelt M#, 2015 Prevalence of Helicobacter pylori vacA, cagA and iceA genotypes and correlation with clinical outcome, Wei G, Chen J, Liu A-Y, Zhang M, Liu X-J, Liu D, Xu J, Liu B-R, Ling H, Wu H-X#, 2012

Areas of Focus

Molecular mechanisms of HIV-host interactions
Design and screening of novel long-acting anti-HIV drugs
Establishment of HIV and other major infectious diseases model and exploration of their immune regulation mechanisms

Publications

Structural and mechanistic bases for a potent HIV-1 capsid inhibitor, Bester, S.M.*, Wei, G.*, Zhao, H.*, Adu-Ampratwum, D., Iqbal, N., Courouble, V.V., Francis, A.C., Annamalai, A.S., Singh, P.K., Shkriabai, N., Van Blerkom, P., Morrison, J., Poeschla, E.M., Engelman, A.N., Melikyan, G.B., Griffin, P.R., Fuchs, J.R., Asturias, F.J. #, Kvaratskhelia, M#., 2020
Sec24C is an HIV-1 host dependency factor crucial for virus replication, Rebensburg, S.V.*, Wei, G.*, Larue, R.C., Lindenberger, J., Francis, A.C., Annamalai, A.S., Morrison, J., Shkriabai, N., Huang, S.W., KewalRamani, V., Poeschla, E.M., Melikyan, G.B., Kvaratskhelia, M#., 2021
Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection, Wei, G., Iqbal, N., Courouble, V.V., Francis, A.C., Annamalai, A.S., Bester, S.M., Singh, P.K Huang, S.W., Shkriabai, N., Haney R., KewalRamani, V., Engelman, A.N, Melikyan, G.B., Griffin, P.R., Asturias, F.J, Kvaratskhelia, M. #, 2022
The chromatin binding domain, including the QPQRYG motif, of feline foamy virus Gag is required for viral DNA integration and nuclear accumulation of Gag and the viral genome, Wei, G., Kehl, T., Bao, Q., Benner, A., Lei, J., Lochelt, M. #, 2018
Structural basis of viral resistance to HIV-1 capsid inhibitor lenacapavir, Bester, S.M., Adu-Ampratwum, D., Annamalai, A.S., Wei, G., Haney R., Fuchs, J.R., Kvaratskhelia, M. #, 2022
The Unique, the Known, and the Unknown of Spumaretrovirus Assembly, Lindemann, D., Hutter, S., Wei, G., Lochelt, M. #, 2021
Replacement of feline foamy virus bet by feline immunodeficiency virus vif yields replicative virus with novel vaccine candidate potential, Ledesma-Feliciano, C., Hagen, S., Troyer, R., Zheng, X., Musselman, E., Slavkovic Lukic, D., Franke, A.M., Maeda, D., Zielonka, J., Munk, C., Wei, G., VandeWoude, S., Lochelt, M. #, 2018
Mutagenesis of N-terminal residues of feline foamy virus Gag reveals entirely distinct functions during capsid formation, particle assembly, Gag processing and budding, Liu Y, Betts MJ, Lei J, Wei G, Bao Q, Kehl T, Russell RB, Lochelt M#, 2016
Replication-Competent Foamy Virus Vaccine Vectors as Novel Epitope Scaffolds for Immunotherapy, Lei J, Osen W, Gardyan A, Hotz-Wagenblatt A, Wei G, Gissmann L, Eichmuller S, Lochelt M#, 2015
Prevalence of Helicobacter pylori vacA, cagA and iceA genotypes and correlation with clinical outcome, Wei G, Chen J, Liu A-Y, Zhang M, Liu X-J, Liu D, Xu J, Liu B-R, Ling H, Wu H-X#, 2012

Hiv Host Interactions Molecular Mechanisms Virology Biochemistry Cell Biology Structural Biology Drug Design Immune Regulation Infectious Diseases

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