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Guochao Wei
Basic Medical Sciences
Peking University
Beijing
Language: Chinese, English, German
Hiv
Host Interactions
Molecular Mechanisms
Virology
Biochemistry
Cell Biology
Structural Biology
Drug Design
Immune Regulation
Infectious Diseases
Areas of Focus
- Molecular mechanisms of HIV-host interactions
- Design and screening of novel long-acting anti-HIV drugs
- Establishment of HIV and other major infectious diseases model and exploration of their immune regulation mechanisms
Work Experience
- 2023-present: Assistant Professor/Researcher, Peking University
- 2018-2023: Postdoctoral Researcher, University of Colorado Anschutz
- 2012-2013: Teaching Assistant, Harbin Medical University
Academic Background & Achievements
- 2013-2018 PhD in Virology: Heidelberg University, Germany
- 2005-2012 Bachelor + Master (Seven-year program) in Basic Medical Science: Harbin Medical University
Publications
- Structural and mechanistic bases for a potent HIV-1 capsid inhibitor, Bester, S.M.*, Wei, G.*, Zhao, H.*, Adu-Ampratwum, D., Iqbal, N., Courouble, V.V., Francis, A.C., Annamalai, A.S., Singh, P.K., Shkriabai, N., Van Blerkom, P., Morrison, J., Poeschla, E.M., Engelman, A.N., Melikyan, G.B., Griffin, P.R., Fuchs, J.R., Asturias, F.J. #, Kvaratskhelia, M#., 2020
- Sec24C is an HIV-1 host dependency factor crucial for virus replication, Rebensburg, S.V.*, Wei, G.*, Larue, R.C., Lindenberger, J., Francis, A.C., Annamalai, A.S., Morrison, J., Shkriabai, N., Huang, S.W., KewalRamani, V., Poeschla, E.M., Melikyan, G.B., Kvaratskhelia, M#., 2021
- Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection, Wei, G., Iqbal, N., Courouble, V.V., Francis, A.C., Annamalai, A.S., Bester, S.M., Singh, P.K Huang, S.W., Shkriabai, N., Haney R., KewalRamani, V., Engelman, A.N, Melikyan, G.B., Griffin, P.R., Asturias, F.J, Kvaratskhelia, M. #, 2022
- The chromatin binding domain, including the QPQRYG motif, of feline foamy virus Gag is required for viral DNA integration and nuclear accumulation of Gag and the viral genome, Wei, G., Kehl, T., Bao, Q., Benner, A., Lei, J., Lochelt, M. #, 2018
- Structural basis of viral resistance to HIV-1 capsid inhibitor lenacapavir, Bester, S.M., Adu-Ampratwum, D., Annamalai, A.S., Wei, G., Haney R., Fuchs, J.R., Kvaratskhelia, M. #, 2022
- The Unique, the Known, and the Unknown of Spumaretrovirus Assembly, Lindemann, D., Hutter, S., Wei, G., Lochelt, M. #, 2021
- Replacement of feline foamy virus bet by feline immunodeficiency virus vif yields replicative virus with novel vaccine candidate potential, Ledesma-Feliciano, C., Hagen, S., Troyer, R., Zheng, X., Musselman, E., Slavkovic Lukic, D., Franke, A.M., Maeda, D., Zielonka, J., Munk, C., Wei, G., VandeWoude, S., Lochelt, M. #, 2018
- Mutagenesis of N-terminal residues of feline foamy virus Gag reveals entirely distinct functions during capsid formation, particle assembly, Gag processing and budding, Liu Y, Betts MJ, Lei J, Wei G, Bao Q, Kehl T, Russell RB, Lochelt M#, 2016
- Replication-Competent Foamy Virus Vaccine Vectors as Novel Epitope Scaffolds for Immunotherapy, Lei J, Osen W, Gardyan A, Hotz-Wagenblatt A, Wei G, Gissmann L, Eichmuller S, Lochelt M#, 2015
- Prevalence of Helicobacter pylori vacA, cagA and iceA genotypes and correlation with clinical outcome, Wei G, Chen J, Liu A-Y, Zhang M, Liu X-J, Liu D, Xu J, Liu B-R, Ling H, Wu H-X#, 2012
