Upload Avatar (500 x 500)
Lele Zhu
Basic Medical Sciences
University of Science and Technology of China
Anhui
Language: English, Chinese
T Cells
Tumors
Infections
Autoimmune Diseases
Immune Evasion
Tolerance
Immunotherapy
Targeted Drugs
Regulation
Mechanisms
Areas of Focus
- Regulation of T cells in tumors, infections, and autoimmune diseases
- Mechanisms of tumor immune evasion and tolerance
- Development of targeted drugs for immunotherapy of tumors and autoimmune diseases
Work Experience
- 2015-2023 - University of Texas MD Anderson Cancer Center - Postdoctoral Fellow and Lecturer
- 2015-2023 - Houston Methodist Research Institute - Research Scientist
- 2023-Present - University of Science and Technology of China - Specially Appointed Professor
Academic Background & Achievements
- 2014 - PhD: Tongji University
- Achievement: Published in top journals like Immunity, Nature Cell Biology, Nature Communications
Publications
- Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer, L.L. Zhu, X.F. Zhou, M. Gu, J. Kim, Y.C. Li, C-J Ko, X.P. Xie, T.X. Gao, X.H. Cheng, and S. C. Sun, 2022
- Myeloid cell TBK1 restricts inflammatory responses, Gao, T., T. Liu, C. J. Ko, L. Zhang, D. Joo, X. Xie, L.L. Zhu, Y. Li, X. Cheng and S. C. Sun, 2022
- NF-kappaB-inducing kinase maintains T cell metabolic fitness in antitumor immunity, M.Gu, X. Zhou, J. H. Sohn, L.L. Zhu, Z. Jie, J. Y. Yang, X. Zheng, X. Xie, J. Yang, Y. Shi, H. D. Brightbill, J. B. Kim, J. Wang, X. Cheng and S. C. Sun, 2021
- DYRK1a mediates BAFF-induced noncanonical NF-kappaB activation to promote autoimmunity and B-cell leukemogenesis, Li, Y., X. Xie, Z. Jie, L.L. Zhu, J. Y. Yang, C. J. Ko, T. Gao, A. Jain, S. Y. Jung, N. Baran, M. Y. Konopleva, X. Cheng and S. C. Sun, 2021
- TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells, Xie, X., L.L. Zhu, Z. Jie, Y. Li, M. Gu, X. Zhou, H. Wang, J. H. Chang, C. J. Ko, X. Cheng and S. C. Sun, 2021
- The E3 ubiquitin ligase Peli1 regulates the metabolic actions of mTORC1 to suppress antitumor T cell responses, Ko, C. J., L. Zhang, Z. Jie, L.L. Zhu, X. Zhou, X. Xie, T. Gao, J. Y. Yang, X. Cheng and S. C. Sun, 2021
- Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination, Zhang, L., C. J. Ko, Y. Li, Z. Jie, L.L. Zhu, X. Zhou, X. Xie, T. Gao, T. Liu, X. Cheng and S. C. Sun, 2021
- Microglia promote autoimmune inflammation via the noncanonical NF-kappaB pathway, Z.Jie, C. J. Ko, H. Wang, X. Xie, Y. Li, M. Gu, L.L. Zhu, J. Y. Yang, T. Gao, W. Ru, S. J. Tang, X. Cheng and S. C. Sun, 2021
- TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis, L.L. Zhu, Y. Li, X. Xie, X. Zhou, M. Gu, Z. Jie, C. J. Ko, T. Gao, B. E. Hernandez, X. Cheng and S. C. Sun, 2019
- TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival, L.L. Zhu, X. Xie, L. Zhang, H. Wang, Z. Jie, X. Zhou, J. Shi, S. Zhao, B. Zhang, X. Cheng and S. C. Sun, 2018
- NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis, Z. Jie, J. Y. Yang, M. Gu, H. Wang, X. Xie, Y. Li, T. Liu, L.L. Zhu, J. Shi, L. Zhang, X. Zhou, D. Joo, H. D. Brightbill, Y. Cong, D. Lin, X. Cheng and S. C. Sun, 2018
- E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunity, L.L. Zhu, T. M. Luo, X. Xu, Y. H. Guo, X. Q. Zhao, T. T. Wang, B. Tang, Y. Y. Jiang, J. F. Xu, X. Lin and X. M. Jia, 2016
- CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity, X.M. Jia, B. Tang, L.L. Zhu, Y. H. Liu, X. Q. Zhao, S. Gorjestani, Y. M. Hsu, L. Yang, J. H. Guan, G. T. Xu and X. Lin, 2014
- C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection, L.L. Zhu, X. Q. Zhao, C. Jiang, Y. You, X. P. Chen, Y. Y. Jiang, X. M. Jia and X. Lin, 2013
Awards
- MD Anderson Cancer Center Center for Inflammation and Cancer Scholar Award
- A. Lavoy Moore Endowment Fund for Lung Cancer Research
- 2020 - Ministry of Education Higher Education Scientific Research Outstanding Achievement Award (Natural Science First Prize)
