Professor | Lele Zhu | Asia Growth Partners

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Name	Lele Zhu
Contact Information	lzhu6@ustc.edu.cn
Language ability	English, Chinese
Province	Anhui

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Name

Lele Zhu

Contact Information

lzhu6@ustc.edu.cn

Language ability

English, Chinese

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Basic Medical Sciences
Academic Background & Achievements	2014 - PhD: Tongji University Achievement: Published in top journals like Immunity, Nature Cell Biology, Nature Communications
Work Experience	2015-2023 - University of Texas MD Anderson Cancer Center - Postdoctoral Fellow and Lecturer 2015-2023 - Houston Methodist Research Institute - Research Scientist 2023-Present - University of Science and Technology of China - Specially Appointed Professor
Awards	MD Anderson Cancer Center Center for Inflammation and Cancer Scholar Award A. Lavoy Moore Endowment Fund for Lung Cancer Research 2020 - Ministry of Education Higher Education Scientific Research Outstanding Achievement Award (Natural Science First Prize)

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Basic Medical Sciences

Academic Background & Achievements

2014 - PhD: Tongji University
Achievement: Published in top journals like Immunity, Nature Cell Biology, Nature Communications

Work Experience

2015-2023 - University of Texas MD Anderson Cancer Center - Postdoctoral Fellow and Lecturer
2015-2023 - Houston Methodist Research Institute - Research Scientist
2023-Present - University of Science and Technology of China - Specially Appointed Professor

Awards

MD Anderson Cancer Center Center for Inflammation and Cancer Scholar Award
A. Lavoy Moore Endowment Fund for Lung Cancer Research
2020 - Ministry of Education Higher Education Scientific Research Outstanding Achievement Award (Natural Science First Prize)

Areas of Focus	Regulation of T cells in tumors, infections, and autoimmune diseases Mechanisms of tumor immune evasion and tolerance Development of targeted drugs for immunotherapy of tumors and autoimmune diseases
Publications	Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer, L.L. Zhu, X.F. Zhou, M. Gu, J. Kim, Y.C. Li, C-J Ko, X.P. Xie, T.X. Gao, X.H. Cheng, and S. C. Sun, 2022 Myeloid cell TBK1 restricts inflammatory responses, Gao, T., T. Liu, C. J. Ko, L. Zhang, D. Joo, X. Xie, L.L. Zhu, Y. Li, X. Cheng and S. C. Sun, 2022 NF-kappaB-inducing kinase maintains T cell metabolic fitness in antitumor immunity, M.Gu, X. Zhou, J. H. Sohn, L.L. Zhu, Z. Jie, J. Y. Yang, X. Zheng, X. Xie, J. Yang, Y. Shi, H. D. Brightbill, J. B. Kim, J. Wang, X. Cheng and S. C. Sun, 2021 DYRK1a mediates BAFF-induced noncanonical NF-kappaB activation to promote autoimmunity and B-cell leukemogenesis, Li, Y., X. Xie, Z. Jie, L.L. Zhu, J. Y. Yang, C. J. Ko, T. Gao, A. Jain, S. Y. Jung, N. Baran, M. Y. Konopleva, X. Cheng and S. C. Sun, 2021 TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells, Xie, X., L.L. Zhu, Z. Jie, Y. Li, M. Gu, X. Zhou, H. Wang, J. H. Chang, C. J. Ko, X. Cheng and S. C. Sun, 2021 The E3 ubiquitin ligase Peli1 regulates the metabolic actions of mTORC1 to suppress antitumor T cell responses, Ko, C. J., L. Zhang, Z. Jie, L.L. Zhu, X. Zhou, X. Xie, T. Gao, J. Y. Yang, X. Cheng and S. C. Sun, 2021 Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination, Zhang, L., C. J. Ko, Y. Li, Z. Jie, L.L. Zhu, X. Zhou, X. Xie, T. Gao, T. Liu, X. Cheng and S. C. Sun, 2021 Microglia promote autoimmune inflammation via the noncanonical NF-kappaB pathway, Z.Jie, C. J. Ko, H. Wang, X. Xie, Y. Li, M. Gu, L.L. Zhu, J. Y. Yang, T. Gao, W. Ru, S. J. Tang, X. Cheng and S. C. Sun, 2021 TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis, L.L. Zhu, Y. Li, X. Xie, X. Zhou, M. Gu, Z. Jie, C. J. Ko, T. Gao, B. E. Hernandez, X. Cheng and S. C. Sun, 2019 TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival, L.L. Zhu, X. Xie, L. Zhang, H. Wang, Z. Jie, X. Zhou, J. Shi, S. Zhao, B. Zhang, X. Cheng and S. C. Sun, 2018 NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis, Z. Jie, J. Y. Yang, M. Gu, H. Wang, X. Xie, Y. Li, T. Liu, L.L. Zhu, J. Shi, L. Zhang, X. Zhou, D. Joo, H. D. Brightbill, Y. Cong, D. Lin, X. Cheng and S. C. Sun, 2018 E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunity, L.L. Zhu, T. M. Luo, X. Xu, Y. H. Guo, X. Q. Zhao, T. T. Wang, B. Tang, Y. Y. Jiang, J. F. Xu, X. Lin and X. M. Jia, 2016 CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity, X.M. Jia, B. Tang, L.L. Zhu, Y. H. Liu, X. Q. Zhao, S. Gorjestani, Y. M. Hsu, L. Yang, J. H. Guan, G. T. Xu and X. Lin, 2014 C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection, L.L. Zhu, X. Q. Zhao, C. Jiang, Y. You, X. P. Chen, Y. Y. Jiang, X. M. Jia and X. Lin, 2013

Areas of Focus

Regulation of T cells in tumors, infections, and autoimmune diseases
Mechanisms of tumor immune evasion and tolerance
Development of targeted drugs for immunotherapy of tumors and autoimmune diseases

Publications

Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer, L.L. Zhu, X.F. Zhou, M. Gu, J. Kim, Y.C. Li, C-J Ko, X.P. Xie, T.X. Gao, X.H. Cheng, and S. C. Sun, 2022
Myeloid cell TBK1 restricts inflammatory responses, Gao, T., T. Liu, C. J. Ko, L. Zhang, D. Joo, X. Xie, L.L. Zhu, Y. Li, X. Cheng and S. C. Sun, 2022
NF-kappaB-inducing kinase maintains T cell metabolic fitness in antitumor immunity, M.Gu, X. Zhou, J. H. Sohn, L.L. Zhu, Z. Jie, J. Y. Yang, X. Zheng, X. Xie, J. Yang, Y. Shi, H. D. Brightbill, J. B. Kim, J. Wang, X. Cheng and S. C. Sun, 2021
DYRK1a mediates BAFF-induced noncanonical NF-kappaB activation to promote autoimmunity and B-cell leukemogenesis, Li, Y., X. Xie, Z. Jie, L.L. Zhu, J. Y. Yang, C. J. Ko, T. Gao, A. Jain, S. Y. Jung, N. Baran, M. Y. Konopleva, X. Cheng and S. C. Sun, 2021
TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells, Xie, X., L.L. Zhu, Z. Jie, Y. Li, M. Gu, X. Zhou, H. Wang, J. H. Chang, C. J. Ko, X. Cheng and S. C. Sun, 2021
The E3 ubiquitin ligase Peli1 regulates the metabolic actions of mTORC1 to suppress antitumor T cell responses, Ko, C. J., L. Zhang, Z. Jie, L.L. Zhu, X. Zhou, X. Xie, T. Gao, J. Y. Yang, X. Cheng and S. C. Sun, 2021
Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination, Zhang, L., C. J. Ko, Y. Li, Z. Jie, L.L. Zhu, X. Zhou, X. Xie, T. Gao, T. Liu, X. Cheng and S. C. Sun, 2021
Microglia promote autoimmune inflammation via the noncanonical NF-kappaB pathway, Z.Jie, C. J. Ko, H. Wang, X. Xie, Y. Li, M. Gu, L.L. Zhu, J. Y. Yang, T. Gao, W. Ru, S. J. Tang, X. Cheng and S. C. Sun, 2021
TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis, L.L. Zhu, Y. Li, X. Xie, X. Zhou, M. Gu, Z. Jie, C. J. Ko, T. Gao, B. E. Hernandez, X. Cheng and S. C. Sun, 2019
TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival, L.L. Zhu, X. Xie, L. Zhang, H. Wang, Z. Jie, X. Zhou, J. Shi, S. Zhao, B. Zhang, X. Cheng and S. C. Sun, 2018
NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis, Z. Jie, J. Y. Yang, M. Gu, H. Wang, X. Xie, Y. Li, T. Liu, L.L. Zhu, J. Shi, L. Zhang, X. Zhou, D. Joo, H. D. Brightbill, Y. Cong, D. Lin, X. Cheng and S. C. Sun, 2018
E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunity, L.L. Zhu, T. M. Luo, X. Xu, Y. H. Guo, X. Q. Zhao, T. T. Wang, B. Tang, Y. Y. Jiang, J. F. Xu, X. Lin and X. M. Jia, 2016
CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity, X.M. Jia, B. Tang, L.L. Zhu, Y. H. Liu, X. Q. Zhao, S. Gorjestani, Y. M. Hsu, L. Yang, J. H. Guan, G. T. Xu and X. Lin, 2014
C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection, L.L. Zhu, X. Q. Zhao, C. Jiang, Y. You, X. P. Chen, Y. Y. Jiang, X. M. Jia and X. Lin, 2013

T Cells Tumors Infections Autoimmune Diseases Immune Evasion Tolerance Immunotherapy Targeted Drugs Regulation Mechanisms

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