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Hongbin He
Basic Medical Sciences
University of Science and Technology of China
Anhui
Language: Chinese, English
Nlrp3
Inflammasome
Activation
Mechanisms
Therapeutic
Strategies
Diseases
Targeting
Research
Development
Areas of Focus
- Exploration of NLRP3 inflammasome activation mechanisms
- Development of therapeutic strategies targeting NLRP3-related diseases
Work Experience
- 2018-2021 - Postdoctoral Research: University of Science and Technology of China
- 2021-Present - Special Associate Researcher: University of Science and Technology of China
Academic Background & Achievements
- 2013 - Bachelor's degree in Agronomy: Jilin University
- 2018 - Doctorate in Science: University of Science and Technology of China
- 2018 - Excellent Doctoral Dissertation: University of Science and Technology of China
- 2018 - President's Award for Excellence: Chinese Academy of Sciences
Publications
- Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity, He H*, Jiang H*, Chen Y*, Ye J, Wang A, Wang C, Liu Q, Liang G, Deng X#, Jiang W#, Zhou R#, 2018
- Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders, Jiang H*, He H*, Chen Y*, Huang W, Cheng J, Ye J, Wang A, Tao J, Wang C, Liu Q, Jin T, Jiang W#, Deng X#, Zhou R#, 2017
- RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor, Chen Y*, He H*, Lin B, Chen Y, Deng X, Jiang W#, Zhou R#, 2021
- Discovery and optimization of 4-oxo-2-thioxo-thiazolidinones as NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inhibitors, Chen Y*, He H*, Jiang H*, Li L, Hu Z, Huang H, Xu Q, Zhou R#, Deng X#, 2020
Awards
- 2018: Excellent Doctoral Dissertation, University of Science and Technology of China
- 2018: President's Award for Excellence, Chinese Academy of Sciences
