Professor | Hangzi Chen | Asia Growth Partners

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Name	Hangzi Chen
Contact Information	chenhz@xmu.edu.cn
Language ability	English, Chinese
Province	Fujian

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Name

Hangzi Chen

Contact Information

chenhz@xmu.edu.cn

Language ability

English, Chinese

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	2003 - B.S. in Biological Sciences: Xiamen University 2009 - Ph.D. in Cell Biology: Xiamen University 2005 - Visiting Student: National University of Singapore
Work Experience	2009 to Present - Xiamen University - Assistant Professor/Associate Professor/Professor
Awards	2018: First Prize of Fujian Natural Science Award (3rd contributor) 2013: First Prize of Fujian Natural Science Award (2nd contributor) 2014: Fujian Youth Top-notch Innovative Talent

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

2003 - B.S. in Biological Sciences: Xiamen University
2009 - Ph.D. in Cell Biology: Xiamen University
2005 - Visiting Student: National University of Singapore

Work Experience

2009 to Present - Xiamen University - Assistant Professor/Associate Professor/Professor

Awards

2018: First Prize of Fujian Natural Science Award (3rd contributor)
2013: First Prize of Fujian Natural Science Award (2nd contributor)
2014: Fujian Youth Top-notch Innovative Talent

Areas of Focus	Metabolic regulation and cell fate determination of tumor cells
Publications	HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma., Chen QT, Zhang ZY, Huang QL, Chen HZ, Hong WB, Lin T, Zhao WX, Wang XM, Ju CY, Wu LZ, Huang YY, Hou PP, Wang WJ, Zhou D, Deng X, Wu Q., 2022 The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8., Zhang JY, Zhou B, Sun RY, Ai YL, Cheng K, Li FN, Wang BR, Liu FJ, Jiang ZH, Wang WJ, Zhou D, Chen HZ, Qiao Wu., 2021 Extracellular vesicles in the tumor immune microenvironment., Hou PP, Chen HZ., 2021 Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression., Yang PB, Hou PP, Liu FY, Hong WB, Chen HZ, Sun XY, Li P, Zhang Y, Ju CY, Luo LJ, Wu SF, Wang ZJ, He JP, Li L, Zhao TJ, Deng X, Lin T, Wu Q., 2020 Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment., Hou PP, Luo LJ, Chen HZ, Chen QT, Bian XL, Wu SF, Zhou JX, Zhao WX, Liu JM, Wang XM, Zhang ZY, Yao LM, Chen QH, Zhou DW, Wu Q., 2020 Nur77-activated lncRNA WFDC21P Attenuates Hepatocarcinogenesis via Modulating Glycolysis., Guan YF, Huang QL, Ai YL, Chen QT, Zhao WX, Wang XM, Wu Q, Chen HZ., 2020 Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis., Zhou B, Zhang JY, Liu XS, Chen HZ, Ai YL, Cheng K, Sun RY, Zhou D, Han J, Wu Q., 2018 Flightless-I Blocks p62-Mediated Recognition of LC3 to Impede Selective Autophagy and Promote Breast Cancer Progression., He JP, Hou PP, Chen QT, Wang WJ, Sun XY, Yang PB, Li YP, Yao LM, Li X, Jiang XD, Chien KY, Zhang ZM, Wu QW, Cowin AJ, Wu Q, Chen HZ., 2018 Nuclear receptor Nur77 facilitates melanoma cell survival under metabolic stress by protecting fatty acid oxidation., Li XX, Wang ZJ, Zheng Y, Guan YF, Yang PB, Chen X, Peng C, He JP, Ai YL, Wu SF, Chien KY, Wu Q, Chen HZ., 2018 Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation., Bian XL, Chen HZ, Yang PB, Li YP, Zhang FN, Zhang JY, Wang WJ, Zhao WX, Zhang S, Chen QT, Zheng Y, Sun XY, Wang XM, Chien KY, Wu Q., 2017 Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation., Li L, Liu Y, Chen HZ, Li FW, Wu JF, Zhang HK, He JP, Xing YZ, Chen Y, Wang WJ, Tian XY, Li AZ, Zhang Q, Huang PQ, Han J, Lin T, Wu Q., 2015

Areas of Focus

Metabolic regulation and cell fate determination of tumor cells

Publications

HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma., Chen QT, Zhang ZY, Huang QL, Chen HZ, Hong WB, Lin T, Zhao WX, Wang XM, Ju CY, Wu LZ, Huang YY, Hou PP, Wang WJ, Zhou D, Deng X, Wu Q., 2022
The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8., Zhang JY, Zhou B, Sun RY, Ai YL, Cheng K, Li FN, Wang BR, Liu FJ, Jiang ZH, Wang WJ, Zhou D, Chen HZ, Qiao Wu., 2021
Extracellular vesicles in the tumor immune microenvironment., Hou PP, Chen HZ., 2021
Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression., Yang PB, Hou PP, Liu FY, Hong WB, Chen HZ, Sun XY, Li P, Zhang Y, Ju CY, Luo LJ, Wu SF, Wang ZJ, He JP, Li L, Zhao TJ, Deng X, Lin T, Wu Q., 2020
Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment., Hou PP, Luo LJ, Chen HZ, Chen QT, Bian XL, Wu SF, Zhou JX, Zhao WX, Liu JM, Wang XM, Zhang ZY, Yao LM, Chen QH, Zhou DW, Wu Q., 2020
Nur77-activated lncRNA WFDC21P Attenuates Hepatocarcinogenesis via Modulating Glycolysis., Guan YF, Huang QL, Ai YL, Chen QT, Zhao WX, Wang XM, Wu Q, Chen HZ., 2020
Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis., Zhou B, Zhang JY, Liu XS, Chen HZ, Ai YL, Cheng K, Sun RY, Zhou D, Han J, Wu Q., 2018
Flightless-I Blocks p62-Mediated Recognition of LC3 to Impede Selective Autophagy and Promote Breast Cancer Progression., He JP, Hou PP, Chen QT, Wang WJ, Sun XY, Yang PB, Li YP, Yao LM, Li X, Jiang XD, Chien KY, Zhang ZM, Wu QW, Cowin AJ, Wu Q, Chen HZ., 2018
Nuclear receptor Nur77 facilitates melanoma cell survival under metabolic stress by protecting fatty acid oxidation., Li XX, Wang ZJ, Zheng Y, Guan YF, Yang PB, Chen X, Peng C, He JP, Ai YL, Wu SF, Chien KY, Wu Q, Chen HZ., 2018
Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation., Bian XL, Chen HZ, Yang PB, Li YP, Zhang FN, Zhang JY, Wang WJ, Zhao WX, Zhang S, Chen QT, Zheng Y, Sun XY, Wang XM, Chien KY, Wu Q., 2017
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation., Li L, Liu Y, Chen HZ, Li FW, Wu JF, Zhang HK, He JP, Xing YZ, Chen Y, Wang WJ, Tian XY, Li AZ, Zhang Q, Huang PQ, Han J, Lin T, Wu Q., 2015

Metabolic Regulation Cell Fate Tumor Cells Metabolic Stress Nuclear Receptor Signal Transduction Microenvironment Remodeling Adaptation Sensing

Lijing Xing - University of Chinese Academy of Sciences

Zhu Cheng Chen - Tsinghua University

Qinghua Tao - Tsinghua University

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