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Wang Geng
Life Science
Xiamen University
Fujian
Language: English, Chinese
Mitochondria
Rna
Import
Metabolism
Function
Regulation
Cellular Processes
Therapeutic
Diseases
Ageing
Areas of Focus
- Mitochondrial RNA import, metabolism, and functions
- Therapeutic research on mitochondrial diseases
- Mechanistic study of normal ageing in mammals
Work Experience
- 2006-2012 - University of California, Los Angeles - Postdoctoral fellow
- 2012-2019 - Tsinghua University - Principle Investigator, Doctoral Supervisor
- 2019-Present - Xiamen University - Professor, Doctoral Supervisor
Academic Background & Achievements
- 1998 - B.S. in Chemistry: Xiamen University
- 2006 - Ph.D. in Biochemistry and Molecular Biology: University of Iowa
Publications
- ANT2 functions as a translocon for mitochondrial cross-membrane translocation of RNAs, Wang P, Zhang L, Chen S, Li R, Liu P, Li X, Luo H, Huo Y, Zhang Z, Cai Y, Liu X, Huang J, Zhou G, Sun Z, Ding S, Shi J, Zhou Z, Yuan R, Liu L, Wu S*, Wang G*, 2024
- Noncoding RNA Terc-53 and hyaluronan receptor Hmmr regulate ageing in mice, Wu S, Cai Y, Zhang L, Li X, Liu X, Zhou G, Luo H, Li R, Huo Y, Zhang Z, Chen S, Huang J, Shi J, Ding S, Sun Z, Zhou Z, Wang P*, Wang G*, 2024
- Mitochondrion-processed TERC regulates senescence without affecting telomerase activities, Zheng Q, Liu P, Gao G, Yuan J, Wang P, Huang J, Xie L, Lu X, Di F, Tong T, Chen J, Lu Z, Guan J, Wang G*, 2019
- Regulation of mitochondrion-associated cytosolic ribosomes by mammalian mitochondrial ribonuclease T2 (RNASET2), Huang J, Liu P, Wang G*, 2018
- Mitochondrial Trafficking and Processing of Telomerase RNA TERC, Cheng Y, Liu P, Zheng Q, Gao G, Yuan J, Wang P, Huang J, Xie L, Lu X, Tong T, Chen J, Lu Z, Guan J, Wang G*, 2018
- Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2, Liu P, Huang J, Zheng Q, Xie L, Lu X, Jin J, Wang G*, 2017
- Mitochondria-targeted RNA import, Wang G, Shimada E, Nili M, Koehler CM, Teitell MA, 2015
- PNPASE and RNA trafficking into mitochondria, Wang G, Shimada E, Koehler CM, Teitell MA, 2012
- Correcting human mitochondrial mutations with targeted RNA import, Wang G, Shimada E, Zhang J, Hong JS, Smith GM, Teitell MA, Koehler CM, 2012
- A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss, von Ameln S, Wang G, Boulouiz R, Rutherford MA, Smith GM, Li Y, Pogoda HM, Nürnberg G, Stiller B, Volk AE, Borck G, Hong JS, Goodyear RJ, Abidi O, Nürnberg P, Hofmann K, Richardson GP, Hammerschmidt M, Moser T, Wollnik B, Koehler CM, Teitell MA, Barakat A, Kubisch C, 2012
- PNPASE regulates RNA import into mitochondria, Wang G, Chen HW, Oktay Y, Zhang J, Allen EL, Smith GM, Fan KC, Hong JS, French SW, McCaffery JM, Lightowlers RN, Morse HC 3rd, Koehler CM, Teitell MA, 2010
- Plasma membrane localization of Ras requires class C Vps proteins and functional mitochondria in Saccharomyces cerevisiae, Wang G, Deschenes RJ, 2006
Awards
- Hosted a National Key R&D Program of the Ministry of Science and Technology
- Hosted a Major Research Plan Cultivation Project of the National Natural Science Foundation
