Professor | Chen-Song Zhang | Asia Growth Partners

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Name	Chen-Song Zhang
Contact Information	cszhang@xmu.edu.cn
Language ability	English, Chinese
Province	Fujian

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Name

Chen-Song Zhang

Contact Information

cszhang@xmu.edu.cn

Language ability

English, Chinese

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	2010 - Bachelor's Degree in Biological Sciences: Xiamen University 2015 - Ph.D. in Biochemistry and Molecular Biology: Xiamen University
Work Experience	2015-2017 - Post-doctoral Researcher, College of Chemistry and Chemical Engineering, Xiamen University 2017-2019 - Post-doctoral Researcher, School of Life Sciences, Xiamen University 2019-Present - Professor, School of Life Sciences, Xiamen University
Awards	2019 - Xiamen University Nanqiang Young Top Talent (Category A) 2017 - Top Ten Advances in Chinese Life Sciences 2017 - Top Ten Research in Chinese Diabetes 2017 - Outstanding Research Paper Award by Cheng-Lu Zou 2017 - Excellent Doctoral Dissertation of Fujian Province 2016 - China Postdoctoral Science Foundation General Grant 2016 - Selected for the First Batch of Youth Talent Support Project by China Association for Science and Technology

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

2010 - Bachelor's Degree in Biological Sciences: Xiamen University
2015 - Ph.D. in Biochemistry and Molecular Biology: Xiamen University

Work Experience

2015-2017 - Post-doctoral Researcher, College of Chemistry and Chemical Engineering, Xiamen University
2017-2019 - Post-doctoral Researcher, School of Life Sciences, Xiamen University
2019-Present - Professor, School of Life Sciences, Xiamen University

Awards

2019 - Xiamen University Nanqiang Young Top Talent (Category A)
2017 - Top Ten Advances in Chinese Life Sciences
2017 - Top Ten Research in Chinese Diabetes
2017 - Outstanding Research Paper Award by Cheng-Lu Zou
2017 - Excellent Doctoral Dissertation of Fujian Province
2016 - China Postdoctoral Science Foundation General Grant
2016 - Selected for the First Batch of Youth Talent Support Project by China Association for Science and Technology

Areas of Focus	Mechanisms of nutrient sensing and regulation of metabolic homeostasis Regulation and physiological functions of AMPK in metabolic control
Publications	Low-dose metformin targets the lysosomal AMPK pathway through PEN2, Ma T, Tian X, Zhang BD, Li MQ, Wang Y, Yang CY, Wu JF, Wei XY, Qu Q, Yu YX, Long ST, Feng JW, Li C, Zhang, CX, Xie CC, Wu YU, Xu ZN, Chen JJ, Yu Y, Huang X, He Y, Yao LM, Zhang L, Zhu, MX, Wang W, Wang ZC, Zhang ML, Bao YQ, Jia WP, Lin SY, Ye ZY, Piao HL, Deng XM, Zhang CS, Lin SC, 2022 Glucose Starvation Blocks Translation at Multiple Levels, Zhang CS, Hardie DG, Lin SC, 2020 Transient Receptor Potential V channels are essential for Glucose Sensing by Aldolase and AMPK, Li MQ#, Zhang CS#, Zong Y#, Feng JW, et al., Lin SC, 2019 Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress, Zong Y#, Zhang CS#, Li MQ, Wang W, Wang ZH, Simon A. H, Ma T, Feng JW, Tian X, Qi Q, Wu YQ, Zhang CX, Ye ZY, Lin SY, Piao HL, D. G Hardie, Lin SC, 2019 Glutaminase GLS1 senses glutamine in a nonenzymatic manner triggering mitochondrial fusion, Cai WF, Zhang C1, Wu YQ, Zhuang G, Ye Z, Zhang CS, and, Lin SC, 2018 Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK, Zhang CS#, Hawley SA#, Zong Y#, Li MQ#, Wang ZC, Gray A, Ma T, Cui JW, Feng JW, Zhu MJ, Wu YQ, Li TY, Ye Z, Lin SY, Yin HY, Piao HL, Hardie DG, Lin SC, 2017 Metformin activates AMPK through the lysosomal pathway, Zhang CS#, Li M#, Ma T#, Zong Y, Cui J, Feng JW, Wu, YQ, Lin SY, and Lin SC, 2016 AMPK Promotes Mitophagy through Facilitating Mitochondrial Fission, Zhang CS, and Lin SC, 2016 RHOBTB3 promotes proteasomal degradation of HIF1alpha through facilitating hydroxylation and suppresses the Warburg effect, Zhang CS#, Liu Q#, Li MQ#, Lin SY#, Peng YY, Wu D, Li TY, Fu Q, Jia WP, Wang XJ, Ma T, Zong Y, Cui JW, Pu CF, Lian GL, Guo GL, Ye ZY, Lin SC, 2015 The Lysosomal v-ATPase-Ragulator Complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism, Zhang CS#, Jiang B#,Li MQ#, Zhu MJ, Peng YY, Zhang YL, Wu YQ, Li TY, Liang Y, Lu ZL, Lian GL, Liu Q, Guo HL,Yin ZY, Ye ZY, Han J, Wu JW, Yin HY, Lin SY, Lin SC, 2014 AMP as a low energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation, Zhang YL#, Guo HL#, Zhang CS#, Lin SY, Li P, WU JW, and Lin SC, 2013

Areas of Focus

Mechanisms of nutrient sensing and regulation of metabolic homeostasis
Regulation and physiological functions of AMPK in metabolic control

Publications

Low-dose metformin targets the lysosomal AMPK pathway through PEN2, Ma T, Tian X, Zhang BD, Li MQ, Wang Y, Yang CY, Wu JF, Wei XY, Qu Q, Yu YX, Long ST, Feng JW, Li C, Zhang, CX, Xie CC, Wu YU, Xu ZN, Chen JJ, Yu Y, Huang X, He Y, Yao LM, Zhang L, Zhu, MX, Wang W, Wang ZC, Zhang ML, Bao YQ, Jia WP, Lin SY, Ye ZY, Piao HL, Deng XM*, Zhang CS*, Lin SC*, 2022
Glucose Starvation Blocks Translation at Multiple Levels, Zhang CS, Hardie DG*, Lin SC*, 2020
Transient Receptor Potential V channels are essential for Glucose Sensing by Aldolase and AMPK, Li MQ#, Zhang CS#, Zong Y#, Feng JW, et al., Lin SC*, 2019
Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress, Zong Y#, Zhang CS#, Li MQ, Wang W, Wang ZH, Simon A. H, Ma T, Feng JW, Tian X, Qi Q, Wu YQ, Zhang CX, Ye ZY, Lin SY, Piao HL, D. G Hardie, Lin SC*, 2019
Glutaminase GLS1 senses glutamine in a nonenzymatic manner triggering mitochondrial fusion, Cai WF, Zhang C1, Wu YQ, Zhuang G, Ye Z, Zhang CS*, and, Lin SC*, 2018
Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK, Zhang CS#, Hawley SA#, Zong Y#, Li MQ#, Wang ZC, Gray A, Ma T, Cui JW, Feng JW, Zhu MJ, Wu YQ, Li TY, Ye Z, Lin SY, Yin HY, Piao HL, Hardie DG*, Lin SC*, 2017
Metformin activates AMPK through the lysosomal pathway, Zhang CS#, Li M#, Ma T#, Zong Y, Cui J, Feng JW, Wu, YQ, Lin SY, and Lin SC*, 2016
AMPK Promotes Mitophagy through Facilitating Mitochondrial Fission, Zhang CS, and Lin SC*, 2016
RHOBTB3 promotes proteasomal degradation of HIF1alpha through facilitating hydroxylation and suppresses the Warburg effect, Zhang CS#, Liu Q#, Li MQ#, Lin SY#, Peng YY, Wu D, Li TY, Fu Q, Jia WP, Wang XJ, Ma T, Zong Y, Cui JW, Pu CF, Lian GL, Guo GL, Ye ZY, Lin SC*, 2015
The Lysosomal v-ATPase-Ragulator Complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism, Zhang CS#, Jiang B#,Li MQ#, Zhu MJ, Peng YY, Zhang YL, Wu YQ, Li TY, Liang Y, Lu ZL, Lian GL, Liu Q, Guo HL,Yin ZY, Ye ZY, Han J, Wu JW, Yin HY, Lin SY, Lin SC*, 2014
AMP as a low energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation, Zhang YL#, Guo HL#, Zhang CS#, Lin SY, Li P, WU JW, and Lin SC*, 2013

Nutrient Sensing Metabolic Homeostasis Ampk Regulation Physiological Functions Metabolic Control Biochemistry Molecular Biology Metabolism Protein Regulation

Shengcai Lin - Xiamen University

Yanfang Wang - Tongji University

Shaojun Dai - Shanghai Normal University

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