Professor | Shengcai Lin | Asia Growth Partners

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Name	Shengcai Lin
Contact Information	linsc@xmu.edu.cn
Language ability	English, Chinese
Province	Fujian

Upload Avatar (500 x 500)

Name

Shengcai Lin

Contact Information

linsc@xmu.edu.cn

Language ability

English, Chinese

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	1984 - B.S. in Biology: Xiamen University 1991 - Ph.D. in Biochemistry: UT Southwestern Medical Center at Dallas 2021 - Member of CAS
Work Experience	1991-1995 - Howard Hughes Medical Institute - Postdoctoral Fellow 1995-2001 - IMCB, Singapore - Principal Investigator 2001-2006 - Hong Kong University of Science and Technology - Assistant Professor/Associate Professor 2003-2017 - Xiamen University - Dean, School of Life Sciences 2006-Present - Xiamen University - Professor, Cheung Kong Scholar
Awards	2021: Member of CAS

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

1984 - B.S. in Biology: Xiamen University
1991 - Ph.D. in Biochemistry: UT Southwestern Medical Center at Dallas
2021 - Member of CAS

Work Experience

1991-1995 - Howard Hughes Medical Institute - Postdoctoral Fellow
1995-2001 - IMCB, Singapore - Principal Investigator
2001-2006 - Hong Kong University of Science and Technology - Assistant Professor/Associate Professor
2003-2017 - Xiamen University - Dean, School of Life Sciences
2006-Present - Xiamen University - Professor, Cheung Kong Scholar

Awards

2021: Member of CAS

Areas of Focus	Molecular mechanisms of metabolic homeostasis Regulation of AMP-activated protein kinase
Publications	Low-dose metformin targets the lysosomal AMPK pathway through PEN2., Ma T, Tian X, Zhang BD, Li MQ, Wang Y, Yang CY, Wu JF, Wei XY, Qu Q, Yu YX, Long ST, Feng JW, Li C, Zhang, CX, Xie CC, Wu YU, Xu ZN, Chen JJ, Yu Y, Huang X, He Y, Yao LM, Zhang L, Zhu, MX, Wang W, Wang ZC, Zhang ML, Bao YQ, Jia WP, Lin SY, Ye ZY, Piao HL, Deng XM, Zhang CS, Lin SC., 2022 AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1., Shi M, Huang XY, Ren XY, Wei XY, Ma Y, Lin ZZ, Liu DT, Song L, Zhao TJ, Li G, Yao L, Zhu M, Zhang C, Xie C, Wu Y, Wu HM, Fan LP, Ou J, Zhan YH, Lin SY, Lin SC., 2021 Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress., Zong Y, Zhang CS, Li M, Wang W, Wang Z, Hawley SA, Ma T, Feng JW, Tian X, Qi Q, Wu YQ, Zhang C, Ye Z, Lin SY, Piao HL, Hardie DG, Lin SC., 2019 Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK., Li M, Zhang CS, Zong Y, Feng JW, Ma T, Hu M, Lin Z, Li X, Xie C, Wu Y, Jiang D, Li Y, Zhang C, Tian X, Wang W, Yang Y, Chen J, Cui J, Wu YQ, Chen X, Liu QF, Wu J, Lin SY, Ye Z, Liu Y, Piao HL, Yu L, Zhou Z, Xie XS, Hardie DG, Lin SC., 2019 AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity., Luo H, Jiang M, Lian G, Liu Q, Shi M, Li TY, Song L, Ye J, He Y, Yao L, Zhang C, Lin ZZ, Zhang CS, Zhao TJ, Jia WP, Li P, Lin SY, Lin SC., 2018 Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK., Zhang CS, Hawley SA, Zong Y, Li MQ, Wang ZC, Gray A, Ma T, Cui JW, Feng JW, Zhu MJ, Wu YQ, Li TY, Ye Z, Lin SY, Yin HY, Piao HL, Hardie DG, Lin SC., 2017 Metformin Activates AMPK through the Lysosomal Pathway., Zhang CS, Li MQ, Ma T, Zong Y, Cui JW, Feng JW, Wu YQ, Lin SY, Lin SC., 2016 The Lysosomal v-ATPase-Ragulator Complex is a Common Activator for AMPK and mTORC1, acting as a Switch between Catabolism and Anabolism., Zhang CS, Jiang B, Li MQ, Zhu MJ, Peng YY, Zhang YL, Wu YQ, Li TY, Liang Y, Lu ZL, Lian GL, Liu Q, Guo HL,Yin ZY, Ye ZY, Han J, Wu JW, Yin HY, Lin SY, Lin SC., 2014 AMP as a low energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation., Zhang YL, Guo HL, Zhang CS, Lin SY, Li P, Wu JW, Lin SC., 2013 GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy., Lin SY, Li TY, Liu Q, Zhang CS, Li X, Chen Y, Zhang SM, Lian GL, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li QX, Han JH, Lin SC*., 2012

Areas of Focus

Molecular mechanisms of metabolic homeostasis
Regulation of AMP-activated protein kinase

Publications

Low-dose metformin targets the lysosomal AMPK pathway through PEN2., Ma T, Tian X, Zhang BD, Li MQ, Wang Y, Yang CY, Wu JF, Wei XY, Qu Q, Yu YX, Long ST, Feng JW, Li C, Zhang, CX, Xie CC, Wu YU, Xu ZN, Chen JJ, Yu Y, Huang X, He Y, Yao LM, Zhang L, Zhu, MX, Wang W, Wang ZC, Zhang ML, Bao YQ, Jia WP, Lin SY, Ye ZY, Piao HL, Deng XM*, Zhang CS*, Lin SC*., 2022
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1., Shi M, Huang XY, Ren XY, Wei XY, Ma Y, Lin ZZ, Liu DT, Song L, Zhao TJ, Li G, Yao L, Zhu M, Zhang C, Xie C, Wu Y, Wu HM, Fan LP, Ou J, Zhan YH, Lin SY*, Lin SC*., 2021
Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress., Zong Y, Zhang CS, Li M, Wang W, Wang Z, Hawley SA, Ma T, Feng JW, Tian X, Qi Q, Wu YQ, Zhang C, Ye Z, Lin SY, Piao HL, Hardie DG, Lin SC*., 2019
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK., Li M, Zhang CS, Zong Y, Feng JW, Ma T, Hu M, Lin Z, Li X, Xie C, Wu Y, Jiang D, Li Y, Zhang C, Tian X, Wang W, Yang Y, Chen J, Cui J, Wu YQ, Chen X, Liu QF, Wu J, Lin SY, Ye Z, Liu Y, Piao HL, Yu L, Zhou Z, Xie XS, Hardie DG, Lin SC*., 2019
AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity., Luo H, Jiang M, Lian G, Liu Q, Shi M, Li TY, Song L, Ye J, He Y, Yao L, Zhang C, Lin ZZ, Zhang CS, Zhao TJ, Jia WP, Li P, Lin SY*, Lin SC*., 2018
Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK., Zhang CS, Hawley SA, Zong Y, Li MQ, Wang ZC, Gray A, Ma T, Cui JW, Feng JW, Zhu MJ, Wu YQ, Li TY, Ye Z, Lin SY, Yin HY, Piao HL, Hardie DG*, Lin SC*., 2017
Metformin Activates AMPK through the Lysosomal Pathway., Zhang CS, Li MQ, Ma T, Zong Y, Cui JW, Feng JW, Wu YQ, Lin SY, Lin SC*., 2016
The Lysosomal v-ATPase-Ragulator Complex is a Common Activator for AMPK and mTORC1, acting as a Switch between Catabolism and Anabolism., Zhang CS, Jiang B, Li MQ, Zhu MJ, Peng YY, Zhang YL, Wu YQ, Li TY, Liang Y, Lu ZL, Lian GL, Liu Q, Guo HL,Yin ZY, Ye ZY, Han J, Wu JW, Yin HY, Lin SY, Lin SC*., 2014
AMP as a low energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation., Zhang YL, Guo HL, Zhang CS, Lin SY, Li P, Wu JW, Lin SC*., 2013
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy., Lin SY, Li TY, Liu Q, Zhang CS, Li X, Chen Y, Zhang SM, Lian GL, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li QX, Han JH, Lin SC*., 2012

Metabolic Homeostasis Cell Growth Autophagy Ampk Gsk3 Tip60 Ulk1 Glucose Metabolism Lysosome V-Atpase

Chen-Song Zhang - Xiamen University

Hong Zhang - University of Chinese Academy of Sciences

Yu Ding - Fudan University

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