Professor | Jiahua Han | Asia Growth Partners

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Name	Jiahua Han
Contact Information	jhan@xmu.edu.cn
Language ability	English, Chinese
Province	Fujian

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Name

Jiahua Han

Contact Information

jhan@xmu.edu.cn

Language ability

English, Chinese

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	1982 - B.S. in Biochemistry: Peking University 1985 - M.S. in Biochemistry: Peking University 1990 - Ph.D. in Molecular Biology: Université Libre de Bruxelles
Work Experience	1990-1992 - University of Texas Southwestern Medical Center - Research Fellow 1993-2007 - The Scripps Research Institute - Assistant Professor/Associate Professor/Professor 2001-2007 - Xiamen University - Adjunct Professor 2007-Present - The Scripps Research Institute - Adjunct Professor 2007-Present - Xiamen University - Full-time Distinguished Professor 2014-2020 - Xiamen University - Vice President
Awards	1991: Jean Stas Award, Belgium 1995: American Heart Association Established Investigator Award 2009: Changjiang Scholar Achievement Award 2009: WuXi AppTec Life Chemistry Research Award First Prize 2009: Lu Jiaxi Excellent Mentor Award 2011: First Prize in Natural Science Research by the Ministry of Education 2011: Xiamen Outstanding Returned Overseas Personnel 2012: First Prize for Excellent Doctoral Dissertation in Fujian Province 2012: National Excellent Doctoral Dissertation 2012: Xiamen May 1st Labor Medal 2012: Xiamen University Nanqiang Special Award 2012: China Overseas Contribution Award 2013: Sixth Tan Jiazhen Life Science Achievement Award 2013: National Natural Science Second Prize 2014: Fujian Province Outstanding Science and Technology Worker 2014: Sanofi-Cell Research Excellent Paper Award 2014: National Outstanding Science and Technology Worker 2015: Fujian Province Major Contribution to Science and Technology Award 2017: First National Innovation Award 2021: Fujian Province Teaching Achievement Special Award

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

1982 - B.S. in Biochemistry: Peking University
1985 - M.S. in Biochemistry: Peking University
1990 - Ph.D. in Molecular Biology: Université Libre de Bruxelles

Work Experience

1990-1992 - University of Texas Southwestern Medical Center - Research Fellow
1993-2007 - The Scripps Research Institute - Assistant Professor/Associate Professor/Professor
2001-2007 - Xiamen University - Adjunct Professor
2007-Present - The Scripps Research Institute - Adjunct Professor
2007-Present - Xiamen University - Full-time Distinguished Professor
2014-2020 - Xiamen University - Vice President

Awards

1991: Jean Stas Award, Belgium
1995: American Heart Association Established Investigator Award
2009: Changjiang Scholar Achievement Award
2009: WuXi AppTec Life Chemistry Research Award First Prize
2009: Lu Jiaxi Excellent Mentor Award
2011: First Prize in Natural Science Research by the Ministry of Education
2011: Xiamen Outstanding Returned Overseas Personnel
2012: First Prize for Excellent Doctoral Dissertation in Fujian Province
2012: National Excellent Doctoral Dissertation
2012: Xiamen May 1st Labor Medal
2012: Xiamen University Nanqiang Special Award
2012: China Overseas Contribution Award
2013: Sixth Tan Jiazhen Life Science Achievement Award
2013: National Natural Science Second Prize
2014: Fujian Province Outstanding Science and Technology Worker
2014: Sanofi-Cell Research Excellent Paper Award
2014: National Outstanding Science and Technology Worker
2015: Fujian Province Major Contribution to Science and Technology Award
2017: First National Innovation Award
2021: Fujian Province Teaching Achievement Special Award

Areas of Focus	Molecular mechanisms in stress responses including inflammation and inflammation-related diseases Functions of stress response pathways in septic shock, atherosclerosis, colitis, and other inflammation-related diseases
Publications	Mosaic composition of RIP1-RIP3 signalling hub and its role in regulating cell death, Chen X, Zhu R, Zhong J, Ying Y, Wang W, Cao Y, Cai H, Li X, Shuai J, Han J, 2022 NLRC4 inflammasome-dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice, Zhang P, Liu Y, Hu L, Huang K, Hong M, Wang Y, Fan X, Richard J. Ulevitch, Han J, 2021 A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade, Yang Z, Wu X, He P, Wang X, Wu J, Ai T, Zhong C, Wu X, Cong Y, Zhu R, Li H, Cai ZY, Mo W, Han J, 2020 Gut Stem Cell Necroptosis by Genome Instability Triggers Bowel Inflammation, Wang R, Li H, Wu J, Cai ZY, Li B, Ni H, Qiu X, Chen H, Liu W, Yang ZH, Liu M, Hu J, Liang Y, Lan P, X, Han J, Mo W, 2020 RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis, Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J, 2018 RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome, Zhang Y, Su SS, Zhao S, Yang Z, Zhong CQ, Chen X, Cai Q, Yang ZH, Huang D, Wu R, Han J, 2017 Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion, He WT, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J, 2015 Ppm1b negatively regulates necroptosis through dephosphorylating Rip3, Chen W, Wu J, Li L, Zhang Z, Ren J, Liang Y, Chen F, Yang C, Zhou Z, Sean Su S, Zheng X, Zhang Z, Zhong CQ, Wan H, Xiao M, Lin X, Feng XH, Han J, 2015 RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis, Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J, 2009 PRAK is essential for ras-induced senescence and tumor suppression, Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong MQ, Frangou CG, Yates JR, 3rd, Wright PE, Han J, 2007 Involvement of microRNA in AU-rich element-mediated mRNA instability, Jing Q, Huang S, Guth S, Zarubin T, Motoyama A, Chen J, Di Padova F, Lin SC, Gram H, Han J, 2005 MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha, Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J, 2002 Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation, Han J, Jiang Y, Li Z, Kravchenko VV, Ulevitch RJ, 1997 A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells, Han J, Lee JD, Bibbs L, Ulevitch RJ, 1994

Areas of Focus

Molecular mechanisms in stress responses including inflammation and inflammation-related diseases
Functions of stress response pathways in septic shock, atherosclerosis, colitis, and other inflammation-related diseases

Publications

Mosaic composition of RIP1-RIP3 signalling hub and its role in regulating cell death, Chen X, Zhu R, Zhong J, Ying Y, Wang W, Cao Y, Cai H, Li X, Shuai J, Han J, 2022
NLRC4 inflammasome-dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice, Zhang P, Liu Y, Hu L, Huang K, Hong M, Wang Y, Fan X, Richard J. Ulevitch, Han J, 2021
A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade, Yang Z, Wu X, He P, Wang X, Wu J, Ai T, Zhong C, Wu X, Cong Y, Zhu R, Li H, Cai ZY, Mo W, Han J, 2020
Gut Stem Cell Necroptosis by Genome Instability Triggers Bowel Inflammation, Wang R, Li H, Wu J, Cai ZY, Li B, Ni H, Qiu X, Chen H, Liu W, Yang ZH, Liu M, Hu J, Liang Y, Lan P, X, Han J, Mo W, 2020
RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis, Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J, 2018
RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome, Zhang Y, Su SS, Zhao S, Yang Z, Zhong CQ, Chen X, Cai Q, Yang ZH, Huang D, Wu R, Han J, 2017
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion, He WT, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J, 2015
Ppm1b negatively regulates necroptosis through dephosphorylating Rip3, Chen W, Wu J, Li L, Zhang Z, Ren J, Liang Y, Chen F, Yang C, Zhou Z, Sean Su S, Zheng X, Zhang Z, Zhong CQ, Wan H, Xiao M, Lin X, Feng XH, Han J, 2015
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis, Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J, 2009
PRAK is essential for ras-induced senescence and tumor suppression, Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong MQ, Frangou CG, Yates JR, 3rd, Wright PE, Han J, 2007
Involvement of microRNA in AU-rich element-mediated mRNA instability, Jing Q, Huang S, Guth S, Zarubin T, Motoyama A, Chen J, Di Padova F, Lin SC, Gram H, Han J, 2005
MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha, Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J, 2002
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation, Han J, Jiang Y, Li Z, Kravchenko VV, Ulevitch RJ, 1997
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells, Han J, Lee JD, Bibbs L, Ulevitch RJ, 1994

Stress Responses Inflammation Cell Differentiation Senescence Cell Death Malignancy Metabolic Pathways Septic Shock Atherosclerosis Colitis

Shuhua Chen - Central South University

Xinqiang He - Peking University

Daichao Xu - University of Chinese Academy of Sciences

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