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Hongling Huang
Life Science
Xiamen University
Fujian
Language: English, Chinese
T Cells
Adaptive Immunity
Cancer Immunotherapy
Molecular Signals
Differentiation
Function
Systems Biology
Crispr Screening
Single Cell Rna-Sequencing
Immune Regulation
Areas of Focus
- Immune signaling in T cell differentiation and function
Work Experience
- 2013-2014 - Postdoctoral Fellow: Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
- 2014-2016 - Postdoctoral Fellow: KU Leuven
- 2017-2021 - Postdoctoral Fellow/Senior Scientist: St. Jude Children's Research Hospital
- 2022-Present - Professor: School of Life Sciences, Xiamen University
Academic Background & Achievements
- 2008 - B.S. in Biotechnology: East China University of Science and Technology
- 2013 - Ph.D. in Biochemistry and Molecular Biology: Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Publications
- Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer., Zhou, P., H. Shi, H. Huang, X. Sun, S. Yuan, N. M. Chapman, J. P. Connelly, S. A. Lim, J. Saravia, A. Kc, S. M. Pruett-Miller and H. Chi, 2023
- cBAF complex components and MYC cooperate early in CD8(+) T cell fate., Guo, A., H. Huang, Z. Zhu, M. J. Chen, H. Shi, S. Yuan, P. Sharma, J. P. Connelly, S. Liedmann, Y. Dhungana, Z. Li, D. Haydar, M. Yang, H. Beere, J. T. Yustein, C. DeRenzo, S. M. Pruett-Miller, J. C. Crawford, G. Krenciute, C. W. M. Roberts, H. Chi and D. R. Green, 2022
- In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8(+) T cell fate decisions., Huang, H., P. Zhou, J. Wei, L. Long, H. Shi, Y. Dhungana, N. M. Chapman, G. Fu, J. Saravia, J. L. Raynor, S. Liu, G. Palacios, Y. D. Wang, C. Qian, J. Yu and H. Chi, 2021
- mTOR signaling at the crossroads of environmental signals and T-cell fate decisions., Huang, H., L. Long, P. Zhou, N. M. Chapman and H. Chi, 2020
- Role of glutamine and interlinked asparagine metabolism in vessel formation., Huang, H., S. Vandekeere, J. Kalucka, L. Bierhansl, A. Zecchin, U. Bruning, A. Visnagri, N. Yuldasheva, J. Goveia, B. Cruys, K. Brepoels, S. Wyns, S. Rayport, B. Ghesquiere, S. Vinckier, L. Schoonjans, R. Cubbon, M. Dewerchin, G. Eelen and P. Carmeliet, 2017
- Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association., Huang, H. L., S. Wang, M. X. Yin, L. Dong, C. Wang, W. Wu, Y. Lu, M. Feng, C. Dai, X. Guo, L. Li, B. Zhao, Z. Zhou, H. Ji, J. Jiang, Y. Zhao, X. Y. Liu and L. Zhang, 2013
- CXCR6 orchestrates brain CD8(+) T cell residency and limits mouse Alzheimer's disease pathology., Su, W., J. Saravia, I. Risch, S. Rankin, C. Guy, N. M. Chapman, H. Shi, Y. Sun, A. Kc, W. Li, H. Huang, S. A. Lim, H. Hu, Y. Wang, D. Liu, Y. Jiao, P. C. Chen, H. Soliman, K. K. Yan, J. Zhang, P. Vogel, X. Liu, G. E. Serrano, T. G. Beach, J. Yu, J. Peng and H. Chi, 2023
- CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity., Long, L., J. Wei, S. A. Lim, J. L. Raynor, H. Shi, J. P. Connelly, H. Wang, C. Guy, B. Xie, N. M. Chapman, G. Fu, Y. Wang, H. Huang, W. Su, J. Saravia, I. Risch, Y. D. Wang, Y. Li, M. Niu, Y. Dhungana, A. Kc, P. Zhou, P. Vogel, J. Yu, S. M. Pruett-Miller, J. Peng and H. Chi, 2021
- Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine., Fu, G., C. S. Guy, N. M. Chapman, G. Palacios, J. Wei, P. Zhou, L. Long, Y. D. Wang, C. Qian, Y. Dhungana, H. Huang, A. Kc, H. Shi, S. Rankin, S. A. Brown, A. Johnson, R. Wakefield, C. G. Robinson, X. Liu, A. Sheyn, J. Yu, S. Jackowski and H. Chi, 2021
- Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy., Wei, J., L. Long, W. Zheng, Y. Dhungana, S. A. Lim, C. Guy, Y. Wang, Y. D. Wang, C. Qian, B. Xu, A. Kc, J. Saravia, H. Huang, J. Yu, J. G. Doench, T. L. Geiger and H. Chi, 2019
- Role of glutamine synthetase in angiogenesis beyond glutamine synthesis., Eelen, G., C. Dubois, A. R. Cantelmo, J. Goveia, U. Bruning, M. DeRan, G. Jarugumilli, J. van Rijssel, G. Saladino, F. Comitani, A. Zecchin, S. Rocha, R. Chen, H. Huang, S. Vandekeere, J. Kalucka, C. Lange, F. Morales-Rodriguez, B. Cruys, L. Treps, L. Ramer, S. Vinckier, K. Brepoels, S. Wyns, J. Souffreau, L. Schoonjans, W. H. Lamers, Y. Wu, J. Haustraete, J. Hofkens, S. Liekens, R. Cubbon, B. Ghesquiere, M. Dewerchin, F. L. Gervasio, X. Li, J. D. van Buul, X. Wu and P. Carmeliet, 2018
- The role of fatty acid beta-oxidation in lymphangiogenesis., Wong, B. W., X. Wang, A. Zecchin, B. Thienpont, I. Cornelissen, J. Kalucka, M. Garcia-Caballero, R. Missiaen, H. Huang, U. Bruning, S. Blacher, S. Vinckier, J. Goveia, M. Knobloch, H. Zhao, C. Dierkes, C. Shi, R. Hagerling, V. Moral-Darde, S. Wyns, M. Lippens, S. Jessberger, S. M. Fendt, A. Luttun, A. Noel, F. Kiefer, B. Ghesquiere, L. Moons, L. Schoonjans, M. Dewerchin, G. Eelen, D. Lambrechts and P. Carmeliet, 2017
Awards
- EMBO Postdoctoral Fellowship (2014-2016)
