2008 - B.S. in Biotechnology: East China University of Science and Technology
2013 - Ph.D. in Biochemistry and Molecular Biology: Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
2013-2014 - Postdoctoral Fellow: Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
2014-2016 - Postdoctoral Fellow: KU Leuven
2017-2021 - Postdoctoral Fellow/Senior Scientist: St. Jude Children's Research Hospital
2022-Present - Professor: School of Life Sciences, Xiamen University
EMBO Postdoctoral Fellowship (2014-2016)
Research
Immune signaling in T cell differentiation and function
Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer., Zhou, P., H. Shi, H. Huang, X. Sun, S. Yuan, N. M. Chapman, J. P. Connelly, S. A. Lim, J. Saravia, A. Kc, S. M. Pruett-Miller and H. Chi, 2023
cBAF complex components and MYC cooperate early in CD8(+) T cell fate., Guo, A., H. Huang, Z. Zhu, M. J. Chen, H. Shi, S. Yuan, P. Sharma, J. P. Connelly, S. Liedmann, Y. Dhungana, Z. Li, D. Haydar, M. Yang, H. Beere, J. T. Yustein, C. DeRenzo, S. M. Pruett-Miller, J. C. Crawford, G. Krenciute, C. W. M. Roberts, H. Chi and D. R. Green, 2022
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8(+) T cell fate decisions., Huang, H., P. Zhou, J. Wei, L. Long, H. Shi, Y. Dhungana, N. M. Chapman, G. Fu, J. Saravia, J. L. Raynor, S. Liu, G. Palacios, Y. D. Wang, C. Qian, J. Yu and H. Chi, 2021
mTOR signaling at the crossroads of environmental signals and T-cell fate decisions., Huang, H., L. Long, P. Zhou, N. M. Chapman and H. Chi, 2020
Role of glutamine and interlinked asparagine metabolism in vessel formation., Huang, H., S. Vandekeere, J. Kalucka, L. Bierhansl, A. Zecchin, U. Bruning, A. Visnagri, N. Yuldasheva, J. Goveia, B. Cruys, K. Brepoels, S. Wyns, S. Rayport, B. Ghesquiere, S. Vinckier, L. Schoonjans, R. Cubbon, M. Dewerchin, G. Eelen and P. Carmeliet, 2017
Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association., Huang, H. L., S. Wang, M. X. Yin, L. Dong, C. Wang, W. Wu, Y. Lu, M. Feng, C. Dai, X. Guo, L. Li, B. Zhao, Z. Zhou, H. Ji, J. Jiang, Y. Zhao, X. Y. Liu and L. Zhang, 2013
CXCR6 orchestrates brain CD8(+) T cell residency and limits mouse Alzheimer's disease pathology., Su, W., J. Saravia, I. Risch, S. Rankin, C. Guy, N. M. Chapman, H. Shi, Y. Sun, A. Kc, W. Li, H. Huang, S. A. Lim, H. Hu, Y. Wang, D. Liu, Y. Jiao, P. C. Chen, H. Soliman, K. K. Yan, J. Zhang, P. Vogel, X. Liu, G. E. Serrano, T. G. Beach, J. Yu, J. Peng and H. Chi, 2023
CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity., Long, L., J. Wei, S. A. Lim, J. L. Raynor, H. Shi, J. P. Connelly, H. Wang, C. Guy, B. Xie, N. M. Chapman, G. Fu, Y. Wang, H. Huang, W. Su, J. Saravia, I. Risch, Y. D. Wang, Y. Li, M. Niu, Y. Dhungana, A. Kc, P. Zhou, P. Vogel, J. Yu, S. M. Pruett-Miller, J. Peng and H. Chi, 2021
Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine., Fu, G., C. S. Guy, N. M. Chapman, G. Palacios, J. Wei, P. Zhou, L. Long, Y. D. Wang, C. Qian, Y. Dhungana, H. Huang, A. Kc, H. Shi, S. Rankin, S. A. Brown, A. Johnson, R. Wakefield, C. G. Robinson, X. Liu, A. Sheyn, J. Yu, S. Jackowski and H. Chi, 2021
Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy., Wei, J., L. Long, W. Zheng, Y. Dhungana, S. A. Lim, C. Guy, Y. Wang, Y. D. Wang, C. Qian, B. Xu, A. Kc, J. Saravia, H. Huang, J. Yu, J. G. Doench, T. L. Geiger and H. Chi, 2019
Role of glutamine synthetase in angiogenesis beyond glutamine synthesis., Eelen, G., C. Dubois, A. R. Cantelmo, J. Goveia, U. Bruning, M. DeRan, G. Jarugumilli, J. van Rijssel, G. Saladino, F. Comitani, A. Zecchin, S. Rocha, R. Chen, H. Huang, S. Vandekeere, J. Kalucka, C. Lange, F. Morales-Rodriguez, B. Cruys, L. Treps, L. Ramer, S. Vinckier, K. Brepoels, S. Wyns, J. Souffreau, L. Schoonjans, W. H. Lamers, Y. Wu, J. Haustraete, J. Hofkens, S. Liekens, R. Cubbon, B. Ghesquiere, M. Dewerchin, F. L. Gervasio, X. Li, J. D. van Buul, X. Wu and P. Carmeliet, 2018
The role of fatty acid beta-oxidation in lymphangiogenesis., Wong, B. W., X. Wang, A. Zecchin, B. Thienpont, I. Cornelissen, J. Kalucka, M. Garcia-Caballero, R. Missiaen, H. Huang, U. Bruning, S. Blacher, S. Vinckier, J. Goveia, M. Knobloch, H. Zhao, C. Dierkes, C. Shi, R. Hagerling, V. Moral-Darde, S. Wyns, M. Lippens, S. Jessberger, S. M. Fendt, A. Luttun, A. Noel, F. Kiefer, B. Ghesquiere, L. Moons, L. Schoonjans, M. Dewerchin, G. Eelen, D. Lambrechts and P. Carmeliet, 2017
Keywords
T CellsAdaptive ImmunityCancer ImmunotherapyMolecular SignalsDifferentiationFunctionSystems BiologyCrispr ScreeningSingle Cell Rna-SequencingImmune Regulation
