Professor | Xinyi He | Asia Growth Partners

Name	Xinyi He
Contact Information	xyhe@sjtu.edu.cn
Language ability	Chinese, English
Province	Shanghai

Name

Xinyi He

Contact Information

xyhe@sjtu.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Shanghai Jiao Tong University
Faculty	Life Sciences
Awards	Shanghai Jiao Tong University Morning Star Young Scholar Award SMC Excellent Young Teacher (Category A) 2015 Ministry of Education Natural Science First Prize (Ranked 4th) 2005 China's Top Ten Scientific and Technological Progress in Universities (Second Author)

University/Lab Affiliation and Title

Shanghai Jiao Tong University

Faculty

Life Sciences

Awards

Shanghai Jiao Tong University Morning Star Young Scholar Award SMC Excellent Young Teacher (Category A)
2015 Ministry of Education Natural Science First Prize (Ranked 4th)
2005 China's Top Ten Scientific and Technological Progress in Universities (Second Author)

Areas of Focus	Sulfur-modified DNA recognition proteins Structure and function of sulfur-modified DNA and its recognition proteins
Publications	A [3Fe-4S] cluster and tRNA-dependent aminoacyltransferase BlsK in the biosynthesis of Blasticidin S, Xiankun Wang, Yuchun Zhao, Yaojie Gao, Xiangkun Luo, Aiqing Du, Zixin Deng, Zabriskie TM, Xinyi He, Ming Jiang, 2021 DNA backbone interactions impact the sequence specificity of DNA sulfur-binding domains: revelations from structural analyses, Hao Yu, Jiayi Li, Guang Liu, Gong Zhao, Yuli Wang, Wenyue Hu, Zixin Deng, Geng Wu, Jianhua Gan, Yi-Lei Zhao, Xinyi He, 2020 Toxin-antitoxin operon kacAT of Klebsiella pneumoniae is regulated by conditional cooperativity via a W-shaped KacA-KacT complex, Hongliang Qian, Hao Yu, Peifei Li, E Zhu, Qingqing Yao, Cui Tai, Zixin Deng, Kenn Gerdes, Xinyi He, Jianhua Gan, Hong-Yu Ou, 2019 Structural basis for the recognition of sulfur in phosphorothioated DNA, Guang Liu, Wencheng Fu, Zhengyi Zhang, Yao He, Hao Yu, Yuli Wang, Xiaolei Wang, Yi-Lei Zhao, Zixin Deng, Geng Wu, Xinyi He, 2018 Identification of a conserved DNA sulfur recognition domain by characterizing the phosphorothioate-specific endonuclease SprMcrA from Streptomyces pristinaespiralis, Hao Yu, Guang Liu, Gong Zhao, Wenyue Hu, Geng Wu, Zixin Deng, Xinyi He, 2018 Guanidine N-methylation by BlsL Is Dependent on Acylation of Beta-amine Arginine in the Biosynthesis of Blasticidin S, Xiankun Wang, Aiqing Du, Guiyang Yu, Zixin Deng, Xinyi He, 2017 Structure of the N-glycosidase MilB in complex with hydroxymethyl CMP reveals its Arg23 specifically recognizes the substrate and controls its entry, Gong Zhao, Geng Wu, Yan Zhang, Guang Liu, Tiesheng Han, Zixin Deng, and Xinyi He, 2014 Recognition and cleavage of 5-methylcytosine DNA by bacterial SRA-HNH proteins, Tiesheng Han, Megumu Yamada-Mabuchi, Gong Zhao, Li Li, Guang Liu, Hong-Yu Ou, Zixin Deng, Yu Zheng, and Xinyi He, 2015 Biosynthesis of the methylarginine residue of peptidyl nucleoside arginomycin in Streptomyces arginensis NRRL 15941, Jun Feng, Jun Wu, Jie Gao, Zhigui Xia, Zixin Deng, and Xinyi He*, 2014

Areas of Focus

Sulfur-modified DNA recognition proteins
Structure and function of sulfur-modified DNA and its recognition proteins

Publications

A [3Fe-4S] cluster and tRNA-dependent aminoacyltransferase BlsK in the biosynthesis of Blasticidin S, Xiankun Wang, Yuchun Zhao, Yaojie Gao, Xiangkun Luo, Aiqing Du, Zixin Deng, Zabriskie TM, Xinyi He*, Ming Jiang*, 2021
DNA backbone interactions impact the sequence specificity of DNA sulfur-binding domains: revelations from structural analyses, Hao Yu, Jiayi Li, Guang Liu, Gong Zhao, Yuli Wang, Wenyue Hu, Zixin Deng, Geng Wu, Jianhua Gan, Yi-Lei Zhao*, Xinyi He*, 2020
Toxin-antitoxin operon kacAT of Klebsiella pneumoniae is regulated by conditional cooperativity via a W-shaped KacA-KacT complex, Hongliang Qian, Hao Yu, Peifei Li, E Zhu, Qingqing Yao, Cui Tai, Zixin Deng, Kenn Gerdes, Xinyi He*, Jianhua Gan*, Hong-Yu Ou*, 2019
Structural basis for the recognition of sulfur in phosphorothioated DNA, Guang Liu, Wencheng Fu, Zhengyi Zhang, Yao He, Hao Yu, Yuli Wang, Xiaolei Wang, Yi-Lei Zhao, Zixin Deng, Geng Wu*, Xinyi He*, 2018
Identification of a conserved DNA sulfur recognition domain by characterizing the phosphorothioate-specific endonuclease SprMcrA from Streptomyces pristinaespiralis, Hao Yu, Guang Liu, Gong Zhao, Wenyue Hu, Geng Wu, Zixin Deng, Xinyi He*, 2018
Guanidine N-methylation by BlsL Is Dependent on Acylation of Beta-amine Arginine in the Biosynthesis of Blasticidin S, Xiankun Wang, Aiqing Du, Guiyang Yu, Zixin Deng, Xinyi He*, 2017
Structure of the N-glycosidase MilB in complex with hydroxymethyl CMP reveals its Arg23 specifically recognizes the substrate and controls its entry, Gong Zhao, Geng Wu, Yan Zhang, Guang Liu, Tiesheng Han, Zixin Deng, and Xinyi He*, 2014
Recognition and cleavage of 5-methylcytosine DNA by bacterial SRA-HNH proteins, Tiesheng Han, Megumu Yamada-Mabuchi, Gong Zhao, Li Li, Guang Liu, Hong-Yu Ou, Zixin Deng, Yu Zheng*, and Xinyi He*, 2015
Biosynthesis of the methylarginine residue of peptidyl nucleoside arginomycin in Streptomyces arginensis NRRL 15941, Jun Feng, Jun Wu, Jie Gao, Zhigui Xia, Zixin Deng, and Xinyi He*, 2014

Sulfur Dna Recognition Proteins Structure Function Sulfur Binding Domain Hydrophobic Conserved Structure Differentiation

Xuemei Chen - Peking University

Xiaolong Liu - University of Chinese Academy of Sciences

Kan Liao - University of Chinese Academy of Sciences

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