Professor | 贺新义 | 数字化转型顾问

Name	贺新义
Contact Information	xyhe@sjtu.edu.cn
Language ability	中文, 英语
Province	上海

Name

贺新义

Contact Information

xyhe@sjtu.edu.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	上海交通大学
Faculty	Life Sciences
Awards	上海交通大学晨星青年学者奖励计划SMC优秀青年教师 (A类) 2015年教育部自然科学一等奖（排名第四） 2005年中国高校十大科技进展（第二作者）

University/Lab Affiliation and Title

上海交通大学

Faculty

Life Sciences

Awards

上海交通大学晨星青年学者奖励计划SMC优秀青年教师 (A类)
2015年教育部自然科学一等奖（排名第四）
2005年中国高校十大科技进展（第二作者）

Areas of Focus	硫修饰DNA识别蛋白硫修饰DNA及其识别蛋白的结构和功能
Publications	A [3Fe-4S] cluster and tRNA-dependent aminoacyltransferase BlsK in the biosynthesis of Blasticidin S, Xiankun Wang, Yuchun Zhao, Yaojie Gao, Xiangkun Luo, Aiqing Du, Zixin Deng, Zabriskie TM, Xinyi He, Ming Jiang, 2021 DNA backbone interactions impact the sequence specificity of DNA sulfur-binding domains: revelations from structural analyses, Hao Yu, Jiayi Li, Guang Liu, Gong Zhao, Yuli Wang, Wenyue Hu, Zixin Deng, Geng Wu, Jianhua Gan, Yi-Lei Zhao, Xinyi He, 2020 Toxin-antitoxin operon kacAT of Klebsiella pneumoniae is regulated by conditional cooperativity via a W-shaped KacA-KacT complex, Hongliang Qian, Hao Yu, Peifei Li, E Zhu, Qingqing Yao, Cui Tai, Zixin Deng, Kenn Gerdes, Xinyi He, Jianhua Gan, Hong-Yu Ou, 2019 Structural basis for the recognition of sulfur in phosphorothioated DNA, Guang Liu, Wencheng Fu, Zhengyi Zhang, Yao He, Hao Yu, Yuli Wang, Xiaolei Wang, Yi-Lei Zhao, Zixin Deng, Geng Wu, Xinyi He, 2018 Identification of a conserved DNA sulfur recognition domain by characterizing the phosphorothioate-specific endonuclease SprMcrA from Streptomyces pristinaespiralis, Hao Yu, Guang Liu, Gong Zhao, Wenyue Hu, Geng Wu, Zixin Deng, Xinyi He, 2018 Guanidine N-methylation by BlsL Is Dependent on Acylation of Beta-amine Arginine in the Biosynthesis of Blasticidin S, Xiankun Wang, Aiqing Du, Guiyang Yu, Zixin Deng, Xinyi He, 2017 Structure of the N-glycosidase MilB in complex with hydroxymethyl CMP reveals its Arg23 specifically recognizes the substrate and controls its entry, Gong Zhao, Geng Wu, Yan Zhang, Guang Liu, Tiesheng Han, Zixin Deng, and Xinyi He, 2014 Recognition and cleavage of 5-methylcytosine DNA by bacterial SRA-HNH proteins, Tiesheng Han, Megumu Yamada-Mabuchi, Gong Zhao, Li Li, Guang Liu, Hong-Yu Ou, Zixin Deng, Yu Zheng, and Xinyi He, 2015 Biosynthesis of the methylarginine residue of peptidyl nucleoside arginomycin in Streptomyces arginensis NRRL 15941, Jun Feng, Jun Wu, Jie Gao, Zhigui Xia, Zixin Deng, and Xinyi He*, 2014

Areas of Focus

硫修饰DNA识别蛋白
硫修饰DNA及其识别蛋白的结构和功能

Publications

A [3Fe-4S] cluster and tRNA-dependent aminoacyltransferase BlsK in the biosynthesis of Blasticidin S, Xiankun Wang, Yuchun Zhao, Yaojie Gao, Xiangkun Luo, Aiqing Du, Zixin Deng, Zabriskie TM, Xinyi He*, Ming Jiang*, 2021
DNA backbone interactions impact the sequence specificity of DNA sulfur-binding domains: revelations from structural analyses, Hao Yu, Jiayi Li, Guang Liu, Gong Zhao, Yuli Wang, Wenyue Hu, Zixin Deng, Geng Wu, Jianhua Gan, Yi-Lei Zhao*, Xinyi He*, 2020
Toxin-antitoxin operon kacAT of Klebsiella pneumoniae is regulated by conditional cooperativity via a W-shaped KacA-KacT complex, Hongliang Qian, Hao Yu, Peifei Li, E Zhu, Qingqing Yao, Cui Tai, Zixin Deng, Kenn Gerdes, Xinyi He*, Jianhua Gan*, Hong-Yu Ou*, 2019
Structural basis for the recognition of sulfur in phosphorothioated DNA, Guang Liu, Wencheng Fu, Zhengyi Zhang, Yao He, Hao Yu, Yuli Wang, Xiaolei Wang, Yi-Lei Zhao, Zixin Deng, Geng Wu*, Xinyi He*, 2018
Identification of a conserved DNA sulfur recognition domain by characterizing the phosphorothioate-specific endonuclease SprMcrA from Streptomyces pristinaespiralis, Hao Yu, Guang Liu, Gong Zhao, Wenyue Hu, Geng Wu, Zixin Deng, Xinyi He*, 2018
Guanidine N-methylation by BlsL Is Dependent on Acylation of Beta-amine Arginine in the Biosynthesis of Blasticidin S, Xiankun Wang, Aiqing Du, Guiyang Yu, Zixin Deng, Xinyi He*, 2017
Structure of the N-glycosidase MilB in complex with hydroxymethyl CMP reveals its Arg23 specifically recognizes the substrate and controls its entry, Gong Zhao, Geng Wu, Yan Zhang, Guang Liu, Tiesheng Han, Zixin Deng, and Xinyi He*, 2014
Recognition and cleavage of 5-methylcytosine DNA by bacterial SRA-HNH proteins, Tiesheng Han, Megumu Yamada-Mabuchi, Gong Zhao, Li Li, Guang Liu, Hong-Yu Ou, Zixin Deng, Yu Zheng*, and Xinyi He*, 2015
Biosynthesis of the methylarginine residue of peptidyl nucleoside arginomycin in Streptomyces arginensis NRRL 15941, Jun Feng, Jun Wu, Jie Gao, Zhigui Xia, Zixin Deng, and Xinyi He*, 2014

硫 Dna 识别蛋白质结构功能硫结合域疏水保守结构区分

梁晶丹 - 上海交通大学

Area of Focus
硫 | Dna | 修饰 | 寡核苷酸 | 药物 | 冷冻电镜 | 天然产物 | 合成 | 磷硫酰 | 生理

李根喜 - 上海大学

Area of Focus
生化 | 分析 | 生物传感 | 传感器 | 蛋白质 | Dna | 电化学 | 纳米技术 | 细胞 | 分子

贺新义 - 上海交通大学

Area of Focus
硫 | Dna | 识别 | 蛋白质 | 结构域 | 疏水 | Sbd | 原子半径 | 电负性 | 修饰

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