Professor | Shijin Zheng | Asia Growth Partners

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Name	Shijin Zheng
Contact Information	jamescheng@xmu.edu.cn
Language ability	Chinese, English
Province	Fujian

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Name

Shijin Zheng

Contact Information

jamescheng@xmu.edu.cn

Language ability

Chinese, English

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	2001 - B.S. in Bioscience: National Tsing-Hua University 2005 - M.S. in Microbiology and Immunology: National Yang-Ming University 2012 - Ph.D. in Biomedical Medicine: Radboud University Nijmegen
Work Experience	2013-2014 - University Medical Center Nijmegen - Postdoctoral Fellow 2015-2016 - Broad Institute of Harvard and MIT - Senior Postdoctoral Fellow 2016-2019 - National Tsing-Hua University - Assistant Professor 2019-Present - Xiamen University - Professor
Awards	Veni laureate of Dutch Research Council (2015): Awarded for research excellence MOST outstanding talent award (2015): Recognized for exceptional talent MOST outstanding young investigator grant (2017): Grant for young researchers NHRI Career Development Grant (2018): Career development support NTHU Young Faculty Research Award (2018): Award for young faculty National Overseas High-Level Young Talent (2019): Recognition for overseas talent 7th Xiamen City Taiwan Distinguished Expert (2020): Distinguished expert recognition Vice Chairman, Youth Committee of Fujian Immunology Society (2020): Leadership role

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

2001 - B.S. in Bioscience: National Tsing-Hua University
2005 - M.S. in Microbiology and Immunology: National Yang-Ming University
2012 - Ph.D. in Biomedical Medicine: Radboud University Nijmegen

Work Experience

2013-2014 - University Medical Center Nijmegen - Postdoctoral Fellow
2015-2016 - Broad Institute of Harvard and MIT - Senior Postdoctoral Fellow
2016-2019 - National Tsing-Hua University - Assistant Professor
2019-Present - Xiamen University - Professor

Awards

Veni laureate of Dutch Research Council (2015): Awarded for research excellence
MOST outstanding talent award (2015): Recognized for exceptional talent
MOST outstanding young investigator grant (2017): Grant for young researchers
NHRI Career Development Grant (2018): Career development support
NTHU Young Faculty Research Award (2018): Award for young faculty
National Overseas High-Level Young Talent (2019): Recognition for overseas talent
7th Xiamen City Taiwan Distinguished Expert (2020): Distinguished expert recognition
Vice Chairman, Youth Committee of Fujian Immunology Society (2020): Leadership role

Areas of Focus	Trained Immunity Epigenetic and Metabolic Reprogramming Infectious Diseases Inflammatory Bowel Diseases Cancer Therapy
Publications	Persistent bone marrow hemozoin accumulation confers a survival advantage against bacterial infection via cell-intrinsic Myd88 signaling., Zhu Y, Gao Q, Zhang J, Cheng Y, Yang S, Xu R, Yuan J, Novakovic B, Netea MG, Cheng SC, 2024 Glutamate oxaloacetate transaminase 1 is dispensable in macrophage differentiation and anti-pathogen response., Zhang L, Wu Z, Qiu X, Zhang J, Cheng SC, 2024 Exploring the Limitations of Mitochondrial Dye as a Genuine Horizontal Mitochondrial Transfer Surrogate., Cheng C, Li H, Zhang J, Cheng SC, 2024 The Glycolysis/Hif-1α axis defines the inflammatory role of IL-4-primed macrophages., Dang B, Gao Q, Zhang L, Zhang J, Cai H, Zhu Y, Zhong Q, Liu J, Niu Y, Mao K, Xiao X, Liu WH, Lin SH, Huang J, Huang SC, Ho PC, Cheng SC, 2023 mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity., Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Veer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG, 2014 Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis., Cheng SC, Scicluna BP, Arts RJ, Gresnigt MS, Lachmandas E, Giamarellos-Bourboulis EJ, Kox M, Manjeri GR, Wagenaars JA, Cremer OL, Leentjens J, van der Meer AJ, van de Veerdonk FL, Bonten MJ, Schultz MJ, Willems PH, Pickkers P, Joosten LA, van der Poll T, Netea MG, 2016 High-Mobility Group Nucleosome-Binding Protein 1 as Endogenous Ligand Induces Innate Immune Tolerance in a TLR4-Sirtuin-1 Dependent Manner in Human Blood Peripheral Mononuclear Cells., Arts RJ, Huang PK, Yang D, Joosten AB, Van der Meer JWM, Oppenheim JJ, Netea MG, Cheng SC, 2018 Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia., Kumar V, Cheng SC, Johnson MD, Smeekens SP, Wojtowicz A, Giamarellos-Bourboulis E, Karjalainen J, Franke L, Withoff S, Plantinga TS, van de Veerdonk FL, van der Meer JW, Joosten LA, Sokol H, Bauer H, Herrmann BG, Bochud PY, Marchetti O, Perfect JR, Xavier RJ, Kullberg BJ, Wijmenga C, Netea MG, 2014

Areas of Focus

Trained Immunity
Epigenetic and Metabolic Reprogramming
Infectious Diseases
Inflammatory Bowel Diseases
Cancer Therapy

Publications

Persistent bone marrow hemozoin accumulation confers a survival advantage against bacterial infection via cell-intrinsic Myd88 signaling., Zhu Y, Gao Q, Zhang J, Cheng Y, Yang S, Xu R, Yuan J, Novakovic B, Netea MG, Cheng SC, 2024
Glutamate oxaloacetate transaminase 1 is dispensable in macrophage differentiation and anti-pathogen response., Zhang L, Wu Z, Qiu X, Zhang J, Cheng SC, 2024
Exploring the Limitations of Mitochondrial Dye as a Genuine Horizontal Mitochondrial Transfer Surrogate., Cheng C, Li H, Zhang J, Cheng SC, 2024
The Glycolysis/Hif-1α axis defines the inflammatory role of IL-4-primed macrophages., Dang B, Gao Q, Zhang L, Zhang J, Cai H, Zhu Y, Zhong Q, Liu J, Niu Y, Mao K, Xiao X, Liu WH, Lin SH, Huang J, Huang SC, Ho PC, Cheng SC, 2023
mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity., Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Veer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG, 2014
Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis., Cheng SC, Scicluna BP, Arts RJ, Gresnigt MS, Lachmandas E, Giamarellos-Bourboulis EJ, Kox M, Manjeri GR, Wagenaars JA, Cremer OL, Leentjens J, van der Meer AJ, van de Veerdonk FL, Bonten MJ, Schultz MJ, Willems PH, Pickkers P, Joosten LA, van der Poll T, Netea MG, 2016
High-Mobility Group Nucleosome-Binding Protein 1 as Endogenous Ligand Induces Innate Immune Tolerance in a TLR4-Sirtuin-1 Dependent Manner in Human Blood Peripheral Mononuclear Cells., Arts RJ, Huang PK, Yang D, Joosten AB, Van der Meer JWM, Oppenheim JJ, Netea MG, Cheng SC, 2018
Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia., Kumar V, Cheng SC, Johnson MD, Smeekens SP, Wojtowicz A, Giamarellos-Bourboulis E, Karjalainen J, Franke L, Withoff S, Plantinga TS, van de Veerdonk FL, van der Meer JW, Joosten LA, Sokol H, Bauer H, Herrmann BG, Bochud PY, Marchetti O, Perfect JR, Xavier RJ, Kullberg BJ, Wijmenga C, Netea MG, 2014

Immunology Memory Innate Immunity Antigen-Independent Epigenetics Metabolism Bcg Vaccine Fungi Pathophysiology Translational Applications

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