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Yingying Zhang
Life Science
Xiamen University
Fujian
Language: English, Chinese
P38 Signaling Pathway
Cell Cycle Regulation
Cell Proliferation
Cell Differentiation
Senescence
Immunity
Development
Tumorigenesis
Rip3
Gsdmd
Areas of Focus
- Intracellular signaling transduction
- Molecular mechanisms of programmed necrosis
- Immune responses to invasive viruses and tumor cells
Work Experience
- 2017-present - Xiamen University - Assistant Professor
- 2020-2022 - University of California, Berkeley - Postdoc
Academic Background & Achievements
- 2006-2010 B.S.: School of Life Sciences, Xiamen University
- 2010-2016 Ph.D.: School of Life Sciences, Xiamen University
Publications
- RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome, Zhang Y#, Su SS#, Zhao S, Yang Z, Zhong CQ, Chen X, Cai Q, Yang ZH, Huang D, Wu R, Han J*, 2017
- Electrophysiologist shows a cation channel function of MLKL, Zhang Y, Han J*, 2016
- The RIP3-RIP1-NF-κB signaling axis is dispensable for necroptotic cells to elicit cross-priming of CD8+ T cells, Ren J#, Jia X, Zhao Y, Shi W, Lu J, Zhang Y, Wu J, Liang B, Wu R, Fu G, Han J*, 2017
- MLKL channel in necroptosis is octamer formed by tetramers in a dyadic process, Huang D#, Zheng X#, Wang ZA#, Chen X, He WT, Zhang Y, Xu JG, Zhao H, Shi W, Wang X, Zhu Y, Han J*, 2017
- Group-DIA: analyzing multiple data-independent acquisition mass spectrometry data files, Li, Y. #, Zhong, C.Q. #, Xu, X., Cai, S., Wu, X., Zhang, Y., Chen, J., Shi, J., Lin, S., and Han, J*, 2015
- Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis, Wu XN#, Yang ZH#, Wang XK, Zhang Y, Wan H, Song Y, Chen X, Shao J, Han J*, 2014
- Regulator of G-Protein Signaling 19 (RGS19) and Its Partner Gα-Inhibiting Activity Polypeptide 3 (GNAI3) Are Required for zVAD-Induced Autophagy and Cell Death in L929 Cells, Wu T, Li Y, Huang D, Han F, Zhang YY, Zhang DW, Han J*, 2014
- Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis, Wu J#, Huang Z#, Ren J#, Zhang Z, He P, Li Y, Ma J, Chen W, Zhang Y, Zhou X, Yang Z, Wu SQ, Chen L, Han J*, 2013
- Diverse Sequence Determinants Control Human and Mouse Receptor Interacting Protein 3 (RIP3) and Mixed Lineage Kinase domain-Like (MLKL) Interaction in Necroptotic Signaling, Chen W#, Zhou Z#, Li L#, Zhong CQ, Zheng X, Wu X, Zhang Y, Ma H, Huang D, Li W, Xia Z, Han J*, 2013
- Investigation of RIP3-dependent protein phosphorylation by quantitative phosphoproteomics, Wu X#, Tian L#, Li J, Zhang Y, Han V, Li Y, Xu X, Li H, Chen X, Chen J, Jin W, Xie Y, Han J*, Zhong CQ*, 2012
