1983-1988: Bachelor of Medicine, Jiangxi Medical College
1991-1994: Master of Medicine, Shantou University Medical College
2000-2003: Doctor of Medicine, Hyogo College of Medicine, Japan
2003-2004: Postdoctoral Researcher, Hyogo College of Medicine, Japan
2004-2009: Head of Cell Biology Research Laboratory, National Cardiovascular Center Research Institute, Japan
2009-2016: Professor/Doctoral Supervisor, Vice President, Director of Academic Committee, Director of Guangdong Provincial Key Laboratory of Molecular Imaging, First Affiliated Hospital of Shantou University Medical College
2017-present: Specially Appointed Professor, Department of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Japan
2018-present: Professor/Doctoral Supervisor, School of Medicine, Xiamen University
2019-present: Vice President, Xiamen University Affiliated Xiang'an Hospital
2022-present: Chairman, Medical Ethics Committee, Xiamen University; Director, Xiamen Key Laboratory of Nucleic Acid Metabolism and Regulation Translational Medicine
Research
Molecular mechanisms of metabolic diseases Molecular hepatology
High Uric Acid Promotes Atherosclerotic Plaque Instability by Apoptosis Targeted Autophagy., Liu W, Yu W, Xie D, Wang Q, Zhao H, Lv J, He F, Xu C, Chen B, Yamamoto T, Koyama H, Cheng J*., 2022
Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation., Zhao H, He F, Lu J, Wang M, Yan Y, Chen B, Xie D, Xu C, Wang Q, Liu W, Yu W, Xi Y, Linqian Yu, Yamamoto T, Koyama H, Zhang C, Wang W and Cheng J*., 2022
High Level of Uric Acid Promotes Atherosclerosis by Targeting NRF2-Mediated Autophagy Dysfunction and Ferroptosis., Yu W, Liu W, Xie D, Wang Q, Xu C, Zhao H, Lv J, He F, Chen B, Yamamoto T, Koyama H, Cheng J*., 2022
Autophagy protects against high uric acid-induced hepatic insulin resistance., He F, Wang M, Zhao H, Xie D, Lv J, Liu W, Yu W, Wang Q, Chen B, Xu C, Yamamoto T, Koyama H, Cheng J*., 2022
Vespakinin-M, a natural peptide from Vespa magnifica, promotes functional recovery in stroke mice., Zhao H, Wang M, Gao Y, Wu X, Xiao H, Yang D, He F, Lv J, Xie D, Wang Q, Liu W, Luo J, Yang Z, Zhang C*, Cheng J*, Zhao Y*., 2022
Silencing TXNIP ameliorates high uric acid-induced insulin resistance via the IRS2/AKT and Nrf2/HO-1 pathways in macrophages., Yu W, Chen C, Zhuang W, Wang W, Liu W, Zhao H, Lv J, Xie D, Wang Q, He F, Xu C, Chen B, Yamamoto T, Koyama H, Cheng J*., 2021
High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling., Xie D, Zhao H, Lu J, He F, Liu W, Yu W, Wang Q, Hisatome I, Yamamoto T, Koyama H, Cheng J*., 2021
High uric acid promotes dysfunction in pancreatic beta cells by blocking IRS2/AKT signalling., Hu Y, Zhao H, Lu J, Xie D, Wang Q, Huang T, Xin H, Hisatome I, Yamamoto T, Wang W*, Cheng J*., 2021
Uric acid inhibits HMGB1-TLR4-NF-kappaB signaling to alleviate oxygen-glucose deprivation/reoxygenation injury of microglia., Wang Q, Zhao H, Gao Y, Lu J, Xie D, Yu W, He F, Liu W, Hisatome I, Yamamoto T, Wang W*, Cheng J*., 2021
Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective., Yu W , Cheng J*., 2020
Metformin ameliorates high uric acid-induced insulin resistance in skeletal muscle cells., Yuan H, Hu Y, Zhu Y, Zhang Y, Luo C, Li Z, Wen T, Zhuang W, Zou J, Hong L, Zhang X, Hisatome I, Yamamoto T, Cheng J*., 2017
无症候性高尿酸血症的治疗-糖尿病的合併について, 程 継東 山本哲也., 2016
High uric acid directly inhibits insulin signalling and induces insulin resistance., Zhu Y, Hu Y, Huang T, Zhang Y, Li Z, Luo C, Luo Y, Yuan H, Hisatome I, Yamamoto T, Cheng J*., 2014
AMPD1: a novel therapeutic target for reversing insulin resistance., Cheng J, Morisaki H, Toyama K, Sugimoto N, Shintani T, Tandelilin A, Hirase T, Holmes EW, Morisaki T., 2014
Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in rat pancreatic β-cells., Zhang Y, Yamamoto T, Hisatome Y, Li Y, Cheng W, Sun N, Cai B, Huang T, Zhu Y, Li Z, Jing X, Cheng J*., 2013
Recombinant HbsAg inhibits LPS-induced COX-2 expression and IL-18 production by interfering with the NF kappa B pathway in a human monocytic cell line, THP-1., Cheng J*, Imanishi H, Morisaki H, Liu W, Nakamura H, Morisaki T, Hada T., 2005
肝線維化と肝癌におけるcyclooxygenase 2に関する検討, 程 継東., 2004
NS-398, a selective cyclooxygenase 2 inhibitor, inhibited cell growth and induced cell cycle arrest in human hepatocellular carcinoma cell lines., Cheng J*, Imanishi H, Amuro Y, Hada T., 2002
Detection of TTV in serum of patients with chronic liver disease and interferon efficacy., Cheng J, Hada T, Fukui K, Ohno M, Hara N, Ohkawa T, Yokoyama Y, Imanishi H, Iijima H, Shimomura S, Yamamoto T, Amuro Y, Higashino K., 1999
Area of Focus
Lipid Metabolism | Pharmacology | Endocrine | Metabolism | Traditional Chinese Medicine | Drug Discovery | Clinical Research | Molecular Biology | Metabolic Diseases | Therapeutics
