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程继东
Medical School
厦门大学
福建
Language: 中文, 英语, 日语
代谢性疾病
分子机制
高尿酸血症
痛风
代谢综合征
葡萄糖代谢
脂质代谢
核酸代谢
肝癌
肝炎
Areas of Focus
- 代谢性疾病的分子机制
- 分子肝病学
Work Experience
- 2003-2004: 博士后研究员, 日本兵库医科大学
- 2004-2009: 室长, 日本国立循环器中心研究所细胞生物学研究室
- 2009-2016: 教授/博导, 副院长, 学术委员会主任, 广东省分子影像重点实验室主任, 汕头大学医学院第一附属医院
- 2017-至今: 特别招聘教授, 日本兵库医科大学糖尿病内分泌代谢科
- 2018-至今: 教授/博导, 厦门大学医学院
- 2019-至今: 副院长, 厦门大学附属翔安医院
- 2022-至今: 厦门大学医学伦理委员会主任委员; 厦门市核酸代谢与调控转化医学重点实验室主任
Academic Background & Achievements
- 1983-1988: 医学学士, 江西医学院
- 1991-1994: 医学硕士, 汕头大学医学院
- 2000-2003: 医学博士, 日本兵库医科大学
Publications
- Mechanistic insights of soluble uric acid-induced insulin resistance: Insulin signaling and beyond., Yu W, Xie D, Yamamoto T, Koyama H, Cheng J*., 2023
- High Uric Acid Promotes Atherosclerotic Plaque Instability by Apoptosis Targeted Autophagy., Liu W, Yu W, Xie D, Wang Q, Zhao H, Lv J, He F, Xu C, Chen B, Yamamoto T, Koyama H, Cheng J*., 2022
- Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation., Zhao H, He F, Lu J, Wang M, Yan Y, Chen B, Xie D, Xu C, Wang Q, Liu W, Yu W, Xi Y, Linqian Yu, Yamamoto T, Koyama H, Zhang C, Wang W and Cheng J*., 2022
- High Level of Uric Acid Promotes Atherosclerosis by Targeting NRF2-Mediated Autophagy Dysfunction and Ferroptosis., Yu W, Liu W, Xie D, Wang Q, Xu C, Zhao H, Lv J, He F, Chen B, Yamamoto T, Koyama H, Cheng J*., 2022
- Autophagy protects against high uric acid-induced hepatic insulin resistance., He F, Wang M, Zhao H, Xie D, Lv J, Liu W, Yu W, Wang Q, Chen B, Xu C, Yamamoto T, Koyama H, Cheng J*., 2022
- Vespakinin-M, a natural peptide from Vespa magnifica, promotes functional recovery in stroke mice., Zhao H, Wang M, Gao Y, Wu X, Xiao H, Yang D, He F, Lv J, Xie D, Wang Q, Liu W, Luo J, Yang Z, Zhang C*, Cheng J*, Zhao Y*., 2022
- Silencing TXNIP ameliorates high uric acid-induced insulin resistance via the IRS2/AKT and Nrf2/HO-1 pathways in macrophages., Yu W, Chen C, Zhuang W, Wang W, Liu W, Zhao H, Lv J, Xie D, Wang Q, He F, Xu C, Chen B, Yamamoto T, Koyama H, Cheng J*., 2021
- High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling., Xie D, Zhao H, Lu J, He F, Liu W, Yu W, Wang Q, Hisatome I, Yamamoto T, Koyama H, Cheng J*., 2021
- High uric acid promotes dysfunction in pancreatic beta cells by blocking IRS2/AKT signalling., Hu Y, Zhao H, Lu J, Xie D, Wang Q, Huang T, Xin H, Hisatome I, Yamamoto T, Wang W*, Cheng J*., 2021
- Uric acid inhibits HMGB1-TLR4-NF-kappaB signaling to alleviate oxygen-glucose deprivation/reoxygenation injury of microglia., Wang Q, Zhao H, Gao Y, Lu J, Xie D, Yu W, He F, Liu W, Hisatome I, Yamamoto T, Wang W*, Cheng J*., 2021
- Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective., Yu W , Cheng J*., 2020
- Metformin ameliorates high uric acid-induced insulin resistance in skeletal muscle cells., Yuan H, Hu Y, Zhu Y, Zhang Y, Luo C, Li Z, Wen T, Zhuang W, Zou J, Hong L, Zhang X, Hisatome I, Yamamoto T, Cheng J*., 2017
- 无症候性高尿酸血症的治疗-糖尿病的合併について, 程 継東 山本哲也., 2016
- High uric acid directly inhibits insulin signalling and induces insulin resistance., Zhu Y, Hu Y, Huang T, Zhang Y, Li Z, Luo C, Luo Y, Yuan H, Hisatome I, Yamamoto T, Cheng J*., 2014
- AMPD1: a novel therapeutic target for reversing insulin resistance., Cheng J, Morisaki H, Toyama K, Sugimoto N, Shintani T, Tandelilin A, Hirase T, Holmes EW, Morisaki T., 2014
- Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in rat pancreatic β-cells., Zhang Y, Yamamoto T, Hisatome Y, Li Y, Cheng W, Sun N, Cai B, Huang T, Zhu Y, Li Z, Jing X, Cheng J*., 2013
- Recombinant HbsAg inhibits LPS-induced COX-2 expression and IL-18 production by interfering with the NF kappa B pathway in a human monocytic cell line, THP-1., Cheng J*, Imanishi H, Morisaki H, Liu W, Nakamura H, Morisaki T, Hada T., 2005
- 肝線維化と肝癌におけるcyclooxygenase 2に関する検討, 程 継東., 2004
- NS-398, a selective cyclooxygenase 2 inhibitor, inhibited cell growth and induced cell cycle arrest in human hepatocellular carcinoma cell lines., Cheng J*, Imanishi H, Amuro Y, Hada T., 2002
- Detection of TTV in serum of patients with chronic liver disease and interferon efficacy., Cheng J, Hada T, Fukui K, Ohno M, Hara N, Ohkawa T, Yokoyama Y, Imanishi H, Iijima H, Shimomura S, Yamamoto T, Amuro Y, Higashino K., 1999
- 食管鳞癌自发细胞凋亡和核增殖抗原p53关系的研究., 程继东, 李淳, 沈忠英., 1998
