Professor | Xin Wang | Asia Growth Partners

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Name	Xin Wang
Contact Information	wangx@xmu.edu.cn
Language ability	English, Chinese
Province	Fujian

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Name

Xin Wang

Contact Information

wangx@xmu.edu.cn

Language ability

English, Chinese

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Medical
Academic Background & Achievements	2009-2013 PhD in Biomedical Sciences: Sanford-Burnham Medical Research Institute 2005-2008 Master's in Pharmacology: Shanghai Jiao Tong University 2001-2005 Bachelor's in Pharmacy: Chongqing Medical University
Work Experience	2015-present - Xiamen University - Professor 2014-2015 - Sanford-Burnham Medical Research Institute - Postdoctoral Researcher 2013-2014 - University of California, San Diego (UCSD) - Postdoctoral Researcher 2013-2013 - Sanford-Burnham Medical Research Institute - Postdoctoral Researcher 2008-2009 - Sanford-Burnham Medical Research Institute - Visiting Scholar
Awards	2023: National Science Fund for Distinguished Young Scholars 2023: 17th Fujian Youth Science and Technology Award 2018: Xiamen Science and Technology Progress First Prize 2018: Xiamen Outstanding Young Talent 2018: National Science Fund for Excellent Young Scholars 2017: Fujian High-Level Innovative Talent Plan Expert 2017: Fujian Distinguished Young Scholar Fund 2016: Minjiang Scholar Distinguished Professor 2016: National High-Level Young Talent 2010: Young Scholar Award of Alzheimer's Association

University/Lab Affiliation and Title

Xiamen University

Faculty

Medical

Academic Background & Achievements

2009-2013 PhD in Biomedical Sciences: Sanford-Burnham Medical Research Institute
2005-2008 Master's in Pharmacology: Shanghai Jiao Tong University
2001-2005 Bachelor's in Pharmacy: Chongqing Medical University

Work Experience

2015-present - Xiamen University - Professor
2014-2015 - Sanford-Burnham Medical Research Institute - Postdoctoral Researcher
2013-2014 - University of California, San Diego (UCSD) - Postdoctoral Researcher
2013-2013 - Sanford-Burnham Medical Research Institute - Postdoctoral Researcher
2008-2009 - Sanford-Burnham Medical Research Institute - Visiting Scholar

Awards

2023: National Science Fund for Distinguished Young Scholars
2023: 17th Fujian Youth Science and Technology Award
2018: Xiamen Science and Technology Progress First Prize
2018: Xiamen Outstanding Young Talent
2018: National Science Fund for Excellent Young Scholars
2017: Fujian High-Level Innovative Talent Plan Expert
2017: Fujian Distinguished Young Scholar Fund
2016: Minjiang Scholar Distinguished Professor
2016: National High-Level Young Talent
2010: Young Scholar Award of Alzheimer's Association

Areas of Focus	Molecular mechanisms of cognitive disorders Drug targets for cognitive disorders
Publications	β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function., Gao Y, Hong Y, Huang L, Zheng S, Zhang H, Wang S, Yao Y, Zhao Y, Zhu L, Xu Q, Chai X, Zeng Y, Zeng Y, Zheng L, Zhou Y, Luo H, Zhang X, Zhang H, Zhou Y, Fu G, Sun H, Huang TY, Zheng Q, Xu H, Wang X., 2023 β2-microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice., Zhao Y, Zheng Q, Hong Y, Gao Y, Hu J, Lang M, Zhang H, Zhou Y, Luo H, Zhang X, Sun H, Yan XX, Huang TY, Wang YJ, Xu H, Liu C, Wang X., 2023 Metabolic reprogramming in astrocytes results in neuronal dysfunction in intellectual disability., Zhang H#, Zheng Q#, Guo T#, Zhang S#, Zheng S, Wang R, Deng Q, Yang G, Zhang S, Tang L, Qi Q, Zhu L, Zhang X-F, Luo H, Zhang X, Sun H, Gao Y, Zhang H, Zhou Y, Han A, Zhang C-S, Xu H, Wang X., 2022 USP25 inhibition ameliorates Alzheimer’s pathology through regulating APP processing and Aβ generation., Zheng Q#, Song B#, Li G#, Cai F#, Wu M, Zhao Y, Jiang L, Guo T, Shen M, Hou H, Zhou Y, Zhao Y, Di A, Zhang L, Zeng F, Zhang X-F, Luo H, Zhang X, Zhang H, Zeng Z, Huang T, Dong C, Qing H, Zhang Y, Zhang Q, Wang X, Wu Y, Xu H, Song W, and Wang X., 2022 SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate., Zhang H#, Hong Y#, Yang W, Wang R, Yao T, Wang J, Liu K, Yuan H, Xu C, Zhou Y, Li G, Zhang L, Luo H, Zhang X, Du D, Sun H, Zheng Q, Zhang Y-W, Zhao Y, Zhou Y, Xu H, Wang X., 2021 Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25., Zheng Q#, Li G#, Wang S, Zhou Y, Liu K, Gao Y, Zhou Y, Zheng L, Zhu L, Deng Q, Wu M, Di A, Zhang L, Zhao Y, Zhang H, Sun H, Dong C, Xu H, Wang X., 2021 The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability., Zeng F#, Ma X#, Zhu L#, Xu Q, Zeng Y, Gao Y, Li G, Guo T, Zhang H, Tang X, Wang Z, Ye Z, Zheng L, Zhang H, Zheng Q, Li K, Lu J, Qi X, Luo H, Zhang X, Wang Z, Zhou Y, Yao Y, Ke R, Zhou Y, Liu Y, Sun H, Huang T, Shao Z, Xu H, and Wang X., 2019 Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction via modulation of glutamate receptor recycling in Down's syndrome., Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang YW, Lipton SA, Hong W, Xu H., 2013

Areas of Focus

Molecular mechanisms of cognitive disorders
Drug targets for cognitive disorders

Publications

β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function., Gao Y, Hong Y, Huang L, Zheng S, Zhang H, Wang S, Yao Y, Zhao Y, Zhu L, Xu Q, Chai X, Zeng Y, Zeng Y, Zheng L, Zhou Y, Luo H, Zhang X, Zhang H, Zhou Y, Fu G, Sun H, Huang TY, Zheng Q, Xu H, Wang X*., 2023
β2-microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice., Zhao Y, Zheng Q, Hong Y, Gao Y, Hu J, Lang M, Zhang H, Zhou Y, Luo H, Zhang X, Sun H, Yan XX, Huang TY, Wang YJ, Xu H, Liu C, Wang X*., 2023
Metabolic reprogramming in astrocytes results in neuronal dysfunction in intellectual disability., Zhang H#, Zheng Q#, Guo T#, Zhang S#, Zheng S, Wang R, Deng Q, Yang G, Zhang S, Tang L, Qi Q, Zhu L, Zhang X-F, Luo H, Zhang X, Sun H, Gao Y, Zhang H, Zhou Y, Han A, Zhang C-S, Xu H, Wang X*., 2022
USP25 inhibition ameliorates Alzheimer’s pathology through regulating APP processing and Aβ generation., Zheng Q#, Song B#, Li G#, Cai F#, Wu M, Zhao Y, Jiang L, Guo T, Shen M, Hou H, Zhou Y, Zhao Y, Di A, Zhang L, Zeng F, Zhang X-F, Luo H, Zhang X, Zhang H, Zeng Z, Huang T, Dong C, Qing H, Zhang Y, Zhang Q, Wang X, Wu Y, Xu H*, Song W*, and Wang X*., 2022
SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate., Zhang H#, Hong Y#, Yang W, Wang R, Yao T, Wang J, Liu K, Yuan H, Xu C, Zhou Y, Li G, Zhang L, Luo H, Zhang X, Du D, Sun H, Zheng Q, Zhang Y-W, Zhao Y, Zhou Y, Xu H, Wang X*., 2021
Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25., Zheng Q#, Li G#, Wang S, Zhou Y, Liu K, Gao Y, Zhou Y, Zheng L, Zhu L, Deng Q, Wu M, Di A, Zhang L, Zhao Y, Zhang H, Sun H, Dong C, Xu H, Wang X*., 2021
The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability., Zeng F#, Ma X#, Zhu L#, Xu Q, Zeng Y, Gao Y, Li G, Guo T, Zhang H, Tang X, Wang Z, Ye Z, Zheng L, Zhang H, Zheng Q, Li K, Lu J, Qi X, Luo H, Zhang X, Wang Z, Zhou Y, Yao Y, Ke R, Zhou Y, Liu Y, Sun H, Huang T, Shao Z, Xu H, and Wang X*., 2019
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction via modulation of glutamate receptor recycling in Down's syndrome., Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang YW, Lipton SA, Hong W, Xu H*., 2013

Cognitive Disorders Molecular Mechanisms Drug Targets Alzheimer'S Disease Down Syndrome Synaptic Function Neurodegeneration Gene Modification Electrophysiology Pharmacology

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