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Wen Lei
Medical School
Xiamen University
Fujian
Language: Chinese, English
Neurodegenerative Diseases
Alzheimer'S
Parkinson'S
Epilepsy
Depression
Pain
Traditional Chinese Medicine
Pharmacology
Health Foods
Pharmaceuticals
Areas of Focus
- Research on the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's, epilepsy, depression, and pain
- Research on the pharmacological basis and mechanisms of traditional Chinese medicine
- Development of health foods and pharmaceuticals
Work Experience
- 1998-2000 - First Military Medical University - Assistant Lecturer, Physician
- 2000-2004 - First Military Medical University - Lecturer, Attending Physician
- 2004-2006 - Southern Medical University - Lecturer, Attending Physician
- 2006-2012 - Southern Medical University - Associate Professor
- 2008-2011 - Georgia Health Sciences University - Postdoctoral Researcher
- 2011-2012 - University of Texas MD Anderson Cancer Center - Postdoctoral Researcher
- 2012-present - Xiamen University - Professor
Academic Background & Achievements
- 1990-1995 Bachelor's in Traditional Chinese Medicine: First Military Medical University
- 1995-1998 Master's in Chinese Medicine: First Military Medical University
- 2002-2005 PhD in Pharmacology: Academy of Military Medical Sciences
Publications
- VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology, Wen L#, Tang FL#, Hong Y, Luo SW, Wang CL, He W, Shen C, Jung JU, Xiong F, Lee DH, Zhang QG, Brann D, Kim TW, Yan R, Mei L, Xiong WC*, 2011
- Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons, Wen L#, Lu YS#, Zhu XH#, Li XM, Woo RS, Chen YJ, Yin DM, Lai C, Terry AV Jr, Vazdarjanova A, Xiong WC, Mei L*, 2010
- Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability, Yu YE#, Wen L#, Silva J, Li Z, Head K, Sossey-Alaoui K, Pao A, Mei L, Cowell JK*, 2010
- New conotoxin SO-3 targeting N-type voltage-sensitive calcium channels, Wen L, Yang S, Zhou W, Zhang Y*, Huang P, 2006
- SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons, Wen L, Yang S, Qiao H, Liu Z, Zhou W, Zhang Y*, Huang P, 2005
- Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain, Li L, Chen SR, Chen H, Wen L, Hittelman WN, Xie JD, Pan HL*, 2016
- VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation, Tian Y, Tang FL, Sun X, Wen L, Mei L, Tang BS, Xiong WC*, 2015
- Increased spinal cord Na+-K+-2Cl- cotransporter-1 (NKCC1) activity contributes to impairment of synaptic inhibition in paclitaxel-induced neuropathic pain, Chen SR, Zhu LH, Chen H, Wen L, Laumet G, Pan HL*, 2014
- Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons, Ting AK, Chen Y, Wen L, Yin DM, Shen C, Tao Y, Liu X, Xiong WC, Mei L*, 2010
- ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation, Chen YJ, Zhang M, Yin DM, Wen L, Ting A, Wang P, Lu YS, Zhu XH, Li SJ, Wu CY, Wang XM, Lai C, Xiong WC, Mei L*, Gao TM*, 2010
Awards
- 2005: 9th Servier Institute - Chinese Pharmacological Society Young Pharmacologist Award
