Professor | Wen Lei | Asia Growth Partners

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Name	Wen Lei
Contact Information	wenlei@xmu.edu.cn
Language ability	Chinese, English
Province	Fujian

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Name

Wen Lei

Contact Information

wenlei@xmu.edu.cn

Language ability

Chinese, English

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Medical
Academic Background & Achievements	1990-1995 Bachelor's in Traditional Chinese Medicine: First Military Medical University 1995-1998 Master's in Chinese Medicine: First Military Medical University 2002-2005 PhD in Pharmacology: Academy of Military Medical Sciences
Work Experience	1998-2000 - First Military Medical University - Assistant Lecturer, Physician 2000-2004 - First Military Medical University - Lecturer, Attending Physician 2004-2006 - Southern Medical University - Lecturer, Attending Physician 2006-2012 - Southern Medical University - Associate Professor 2008-2011 - Georgia Health Sciences University - Postdoctoral Researcher 2011-2012 - University of Texas MD Anderson Cancer Center - Postdoctoral Researcher 2012-present - Xiamen University - Professor
Awards	2005: 9th Servier Institute - Chinese Pharmacological Society Young Pharmacologist Award

University/Lab Affiliation and Title

Xiamen University

Faculty

Medical

Academic Background & Achievements

1990-1995 Bachelor's in Traditional Chinese Medicine: First Military Medical University
1995-1998 Master's in Chinese Medicine: First Military Medical University
2002-2005 PhD in Pharmacology: Academy of Military Medical Sciences

Work Experience

1998-2000 - First Military Medical University - Assistant Lecturer, Physician
2000-2004 - First Military Medical University - Lecturer, Attending Physician
2004-2006 - Southern Medical University - Lecturer, Attending Physician
2006-2012 - Southern Medical University - Associate Professor
2008-2011 - Georgia Health Sciences University - Postdoctoral Researcher
2011-2012 - University of Texas MD Anderson Cancer Center - Postdoctoral Researcher
2012-present - Xiamen University - Professor

Awards

2005: 9th Servier Institute - Chinese Pharmacological Society Young Pharmacologist Award

Areas of Focus	Research on the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's, epilepsy, depression, and pain Research on the pharmacological basis and mechanisms of traditional Chinese medicine Development of health foods and pharmaceuticals
Publications	VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology, Wen L#, Tang FL#, Hong Y, Luo SW, Wang CL, He W, Shen C, Jung JU, Xiong F, Lee DH, Zhang QG, Brann D, Kim TW, Yan R, Mei L, Xiong WC, 2011 Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons, Wen L#, Lu YS#, Zhu XH#, Li XM, Woo RS, Chen YJ, Yin DM, Lai C, Terry AV Jr, Vazdarjanova A, Xiong WC, Mei L, 2010 Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability, Yu YE#, Wen L#, Silva J, Li Z, Head K, Sossey-Alaoui K, Pao A, Mei L, Cowell JK, 2010 New conotoxin SO-3 targeting N-type voltage-sensitive calcium channels, Wen L, Yang S, Zhou W, Zhang Y, Huang P, 2006 SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons, Wen L, Yang S, Qiao H, Liu Z, Zhou W, Zhang Y, Huang P, 2005 Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain, Li L, Chen SR, Chen H, Wen L, Hittelman WN, Xie JD, Pan HL, 2016 VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation, Tian Y, Tang FL, Sun X, Wen L, Mei L, Tang BS, Xiong WC, 2015 Increased spinal cord Na+-K+-2Cl- cotransporter-1 (NKCC1) activity contributes to impairment of synaptic inhibition in paclitaxel-induced neuropathic pain, Chen SR, Zhu LH, Chen H, Wen L, Laumet G, Pan HL, 2014 Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons, Ting AK, Chen Y, Wen L, Yin DM, Shen C, Tao Y, Liu X, Xiong WC, Mei L, 2010 ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation, Chen YJ, Zhang M, Yin DM, Wen L, Ting A, Wang P, Lu YS, Zhu XH, Li SJ, Wu CY, Wang XM, Lai C, Xiong WC, Mei L, Gao TM*, 2010

Areas of Focus

Research on the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's, epilepsy, depression, and pain
Research on the pharmacological basis and mechanisms of traditional Chinese medicine
Development of health foods and pharmaceuticals

Publications

VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology, Wen L#, Tang FL#, Hong Y, Luo SW, Wang CL, He W, Shen C, Jung JU, Xiong F, Lee DH, Zhang QG, Brann D, Kim TW, Yan R, Mei L, Xiong WC*, 2011
Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons, Wen L#, Lu YS#, Zhu XH#, Li XM, Woo RS, Chen YJ, Yin DM, Lai C, Terry AV Jr, Vazdarjanova A, Xiong WC, Mei L*, 2010
Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability, Yu YE#, Wen L#, Silva J, Li Z, Head K, Sossey-Alaoui K, Pao A, Mei L, Cowell JK*, 2010
New conotoxin SO-3 targeting N-type voltage-sensitive calcium channels, Wen L, Yang S, Zhou W, Zhang Y*, Huang P, 2006
SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons, Wen L, Yang S, Qiao H, Liu Z, Zhou W, Zhang Y*, Huang P, 2005
Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain, Li L, Chen SR, Chen H, Wen L, Hittelman WN, Xie JD, Pan HL*, 2016
VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation, Tian Y, Tang FL, Sun X, Wen L, Mei L, Tang BS, Xiong WC*, 2015
Increased spinal cord Na+-K+-2Cl- cotransporter-1 (NKCC1) activity contributes to impairment of synaptic inhibition in paclitaxel-induced neuropathic pain, Chen SR, Zhu LH, Chen H, Wen L, Laumet G, Pan HL*, 2014
Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons, Ting AK, Chen Y, Wen L, Yin DM, Shen C, Tao Y, Liu X, Xiong WC, Mei L*, 2010
ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation, Chen YJ, Zhang M, Yin DM, Wen L, Ting A, Wang P, Lu YS, Zhu XH, Li SJ, Wu CY, Wang XM, Lai C, Xiong WC, Mei L*, Gao TM*, 2010

Neurodegenerative Diseases Alzheimer'S Parkinson'S Epilepsy Depression Pain Traditional Chinese Medicine Pharmacology Health Foods Pharmaceuticals

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