1993.09~1998.06 Bachelor of Medicine: Xianning Medical College, Hubei Province
2002.09~2005.12 Master of Science: Huazhong University of Science and Technology, Tongji Medical College
2006.09~2009.07 Doctor of Medicine: Huazhong University of Science and Technology, Tongji Medical College
2013.09~2014.10 Postdoctoral Research: Mayo Clinic, USA
1998.09~2009.07 - Xianning Medical College, Hubei Province - Assistant Lecturer, Lecturer
2009.08~2012.07 - Xiamen University School of Medicine - Assistant Professor
2012.08~2020.07 - Xiamen University School of Medicine - Associate Professor
2020.08~Present - Xiamen University School of Medicine - Professor
2020: National Second Prize in the Sixth National Undergraduate Basic Medicine Innovation Forum and Experimental Design Competition
2018: National First Prize in the Fifth National Undergraduate Basic Medicine Innovation Forum and Experimental Design Competition
2017: Third Prize in the National University (Medical) Micro-course Teaching Competition
2018: Excellent Instructor in the Undergraduate Science and Technology Innovation Competition at Xiamen University
2017-2020: Excellent Instructor in the University Student Innovation and Entrepreneurship Training Program at Xiamen University School of Medicine
Research
Microglia and Neurodegenerative Diseases
Triggering receptor expressed on myeloid cells-2 (TREM2) interacts with colony-stimulating factor 1 receptor (CSF1R) but is not necessary for CSF1/CSF1R-mediated microglia survival., Baoying Cheng, Xin Li, Kai Dai, Shengshun Duan, Zhouyi Rong, Yingmin Chen, Liangcheng Lü, Zhaoji Liu, Xiaohua Huang, Huaxi Xu, Yun-Wu Zhang, Honghua Zheng, 2021
Proteolytic Shedding of Human Colony-Stimulating Factor 1 Receptor and its implication., Yue Wei, Menghui Ma, Sheng Lin, Xin Li, Yue Shu, Ziwei Wang, Yuhang Zhou, Banglian Hu, Baoying Cheng, Shengshun Duan, Xiaohua Huang, Huaxi Xu, Yun-Wu Zhang, Honghua Zheng, 2021
TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities., Liu Z, Ning J, Zheng X, Meng J, Han L, Zheng H, Zhong L, Chen XF, Zhang X, Luo H, Can D, Xu H, Zhang YW, 2020
Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine models., Rong Z, Cheng B, Zhong L, Ye X, Li X, Jia L, Li Y, Shue F, Wang N, Cheng Y, Huang X, Liu CC, Fryer JD, Wang X, Zhang YW, Zheng H, 2020
Cortical Damage Associated With Cognitive and Motor Impairment in Hereditary Spastic Paraplegia: Evidence of a Novel SPAST Mutation., Lin JZ, Zheng HH, Ma QL, Wang C, Fan LP, Wu HM, Wang DN, Zhang JX, Zhan YH, 2020
ErbB4 Mutation that Decreased NRG1-ErbB4 Signaling Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis/Frontotemporal Dementia., Sun L, Cheng B, Zhou Y, Fan Y, Li W, Qiu Q, Fang Y, Xiao S, Zheng H, Li X, 2020
A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II., Zhao S, Li Z, Zhang M, Zhang L, Zheng H, Ning J, Wang Y, Wang F, Zhang X, Gan H, Wang Y, Zhang X, Luo H, Bu G, Xu H, Yao Y, Zhang YW, 2019
Silencing MicroRNA-155 Attenuates Kainic Acid-Induced Seizure by Inhibiting Microglia Activation., Fu H, Cheng Y, Luo H, Rong Z, Li Y, Lu P, Ye X, Huang W, Qi Z, Li X, Cheng B, Wang X, Yao Y, Zhang YW, Zheng W, Zheng H, 2019
TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism., Zheng H, Cheng B, Li Y, Li X, Chen X, Zhang YW, 2018
Neuron-specific menin deletion leads to synaptic dysfunction and cognitive impairment by modulating p35 expression., Zhuang K, Huang C, Leng L, Zheng H, Gao Y, Chen G, Ji Z, Sun H, Hu Y, Wu D, Shi M, Li H, Zhao Y, Zhang Y, Xue M, Bu G, Huang TY, Xu H, Zhang J, 2018
Protective role of L-3-n-butylphthalide in cognitive function and dysthymic disorders in mouse with chronic epilepsy., Ye X, Rong Z, Li Y, Wang X, Cheng B, Cheng Y, Luo H, Ti Y, Huang X, Liu Z, Zhang Yw, Zheng W, Zheng H, 2018
Compensatory mechanisms modulate the neuronal excitability in a kainic acid-induced epilepsy mouse model., Pan G, Chen Z, Zheng H, Zhang Yw, Xu H, Bu G, Zheng H, Li Y, 2018
Identification of a Novel Hemizygous SQSTM1 Nonsense Mutation in Atypical Behavioral Variant Frontotemporal Dementia., Sun L, Rong Z, Li W, Zheng H, Xiao S, Li X, 2018
TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway., Zheng H, Jia L, Liu CC, Rong Z, Zhong L, Yang L, Chen XF, Fryer JD, Wang X, Zhang YW, Xu H, Bu G, 2017
Synaptic Adhesion Molecule Pcdh-γC5 Mediates Synaptic Dysfunction in Alzheimer's Disease., Li Y, Chen Z, Gao Y, Pan G, Zheng H, Zhang Y, Xu H, Bu G, Zheng H, 2017
A novel presenilin 1 mutation (F388L) identified in a Chinese family with early-onset Alzheimer's disease., Zhan Y, Zheng H, Wang C, Rong Z, Xiao N, Ma Q, Zhang YW, 2017
Protective role of miR-23b-3p in kainic acid-induced seizure., Zhan L, Yao Y, Fu H, Li Z, Wang F, Zhang X, He W, Zheng W, Zhang Y, Zheng H, 2016
Successful surgery in lesional epilepsy secondary to posterior quandrant ulegyria coexisting with benign childhood focal epilepsy: A case report., Wang F, Zheng H, Zhang X, Li Y, Gao Z, Wang Y, Liu X, Yao Y, 2016
Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation., Zheng H, Liu CC, Atagi Y, Chen XF, Jia L, Yang L, He W, Zhang X, Kang SS, Rosenberry TL, Fryer JD, Zhang YW, Xu H, Bu G, 2016
LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways., Yang L, Liu CC, Zheng H, Kanekiyo T, Atagi Y, Jia L, Wang D, N'songo A, Can D, Xu H, Chen XF, Bu G, 2016
Soluble TREM2 induces inflammatory responses and enhances microglial survival., Zhong L, Chen XF, Wang T, Wang Z, Liao C, Wang Z, Huang R, Wang D, Li X, Wu L, Jia L, Zheng H, Painter M, Atagi Y, Liu CC, Zhang YW, Fryer JD, Xu H, Bu G, 2017
HIV-1 Tat inhibits EAAT-2 through AEG-1 upregulation in models of HIV-associated neurocognitive disorder., Ye X, Zhang Y, Xu Q, Zheng H, Wu X, Qiu J, Zhang Z, Wang W, Shao Y, Xing HQ, 2017
Menin mediates Tat-induced neuronal apoptosis in brain frontal cortex of SIV-infected macaques and in Tat-treated cells., Wang J, Zhang Y, Xu Q, Qiu J, Zheng H, Ye X, Xue Y, Yin Y, Zhang Z, Liu Y, Hao Y, Wei Q, Wang W, Mori K, Izumo S, Kubota R, Shao Y, Xing HQ, 2017
Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan., Fu Y, Zhao J, Atagi Y, Nielsen HM, Liu CC, Zheng H, Shinohara M, Kanekiyo T, Bu G, 2016
Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)., Atagi Y, Liu CC, Painter MM, Chen XF, Verbeeck C, Zheng H, Li X, Rademakers R, Kang SS, Xu H, Younkin S, Das P, Fryer JD, Bu G, 2015
MiR-219 Protects Against Seizure in the Kainic Acid Model of Epilepsy., Zheng H, Tang R, Yao Y, Ji Z, Cao Y, Liu Z, Peng F, Wang W, Can D, Xing H, Bu G, Xu H, Zhang YW, Zheng W, 2016
The PI3K/Akt and ERK1/2 signaling pathways mediate the erythropoietin-modulated calcium influx in kainic acid-induced epilepsy., Zheng H, Wang X, Tang Z, Zheng W, Li Z, 2013
Excitotoxicity of TNFalpha derived from KA activated microglia on hippocampal neurons in vitro and in vivo., Zhu W, Zheng H, Shao X, Wang W, Yao Q, Li Z, 2010
Kainic acid-activated microglia mediate increased excitability of rat hippocampal neurons in vitro and in vivo: crucial role of interleukin-1beta., Zheng H, Zhu W, Zhao H, Wang X, Wang W, Li Z, 2010
Ciliary neurotrophic factor-treated astrocyte conditioned medium regulates the L-type calcium channel activity in rat cortical neurons., Wang X, Zheng H, Liu C, Zhu C, Wang W, Li Z, 2008
Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells., Chen Y, Li D, Liu H, Xu H, Zheng H, Feng Q, Li W, Zhao C, Wang Z, Wang X, 2011
Menin represses malignant phenotypes of melanoma through regulating multiple pathways., Gao SB, Feng ZJ, Xu B, Chen Y, Zheng HH, Yin P, Hua X, Jin GH, 2011
