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Songlin Shi
Medical School
Xiamen University
Fujian
Language: Chinese, English
Liver Fibrosis
Liver Cancer
Tumor Metastasis
Npm Protein
Hnrnpa2/B1
Gene Therapy
Drug Development
Fibrotic Diseases
Cell Biology
Cancer Mechanisms
Areas of Focus
- Mechanisms of liver fibrosis and liver cancer
- Development of anti-tumor drugs and cell gene therapy
- Mechanisms and drug development for fibrotic diseases, focusing on liver fibrosis
Work Experience
- 2012/8-present - Xiamen University, School of Medicine - Associate Professor
- 2014/5-2015/5 - University of Pennsylvania, School of Medicine - Visiting Scholar
- 2009/8-2012/7 - Xiamen University, School of Medicine - Assistant Professor
- 2007/7-2009/7 - Xiamen University, College of Chemistry and Chemical Engineering - Postdoctoral Researcher
Academic Background & Achievements
- 2001/9–2007/6 PhD in Cell Biology: Xiamen University
- 1993/9–1997/7 Bachelor's in Microbiology: Anhui University
Publications
- Screening of small molecule compounds targeting hnRNPA2 protein, Yuan-Rong Zheng, Chao-Jie Wang, Ling Yang, Yu-Jun Zhang, Mei-Juan Fang, He Chang, Kai-Qiang Guo, Song-Lin Shi, 2023
- Targeting the SOX2/CDP protein complex with a peptide suppresses the malignant progression of esophageal squamous cell carcinoma, Yunyun Chen, Kun Zhang, Rui Zhang, Zhuo Wang, Liang Yang, Tingting Zhao, Shihui Zhang, Yong Lin, Hongzhou Zhao, Yongpan Liu, Yuxuan Wei, Yijian Zhou, Jiaying Zhang, Xianzong Ye, Jing Zhao, Xinxin Li, Jianwen Que, Songlin Shi, Kuancan Liu, 2023
- NPM promotes hepatotoxin-induced fibrosis by inhibiting ROS-induced apoptosis of hepatic stellate cells and upregulating lncMIAT-induced TGF-β2, Ding X, Zhu XL, Xu DH, Li S, Yang Q, Feng X, Wei YG, Li H, Yang L, Zhang YJ, Deng XL, Liu KC, Shi SL, 2023
- NPM1 promotes cell proliferation by targeting PRDX6 in colorectal cancer, Dan Wang, Yin Li, Yanling Liu, Shuyu Cheng, Fan Liu, Renjie Zuo, Chenchun Ding, Songlin Shi and Guoyan Liu, 2022
- HnRNPA2B1 promotes the proliferation of breast cancer MCF-7 cells via STAT3 pathway, Li-Bin Gao, Xin-Le Zhu, Ling Yang, Zhen-Qiang Xu, Song-Lin Shi, 2021
- The roles of hnRNP A2/B1 in RNA biology and disease (Invited review), Liu Y, Shi S-L, 2020
- Heterogeneous nuclear ribonucleoprotein A2/B1 is a negative regulator of human breast cancer metastasis by maintaining the balance of multiple genes and pathways, Yu Liu, Huan Li, Fan Liu, Li-Bin Gao, Rong Han, Chen Chen, Xue Ding, Shuang Li, Kun Lu, Ling Yang, Hui-Min Tian, Bin-Bin Chen, Xiao Li, Dong-Hui Xu, Xiao-Ling Deng, Song-Lin Shi, 2020
- FNDC3B circular RNA promotes the migration and invasion of gastric cancer cells via the regulation of E‐cadherin and CD44 expression, Yuling Hong, Haifeng Qin, Yin Li, Yuhai Zhang, Xunrong Zhuang, Lei Liu, Kun Lu, Long Li, Xiaoling Deng, Fan Liu, Fan Liu, Songlin Shi, Guoyan Liu, 2019
- 1433ε is a nuclear matrix protein, and its altered expression and localization are associated with curcumin-induced apoptosis of MG63 cells, Kun Lu, Gang Rui, Fan Liu, Ling Yang, Xiao-Ling Deng, Song-Lin Shi and Qi-Fu Li, 2018
- Ephrin-B2/Fc promotes proliferation and migration, and suppresses apoptosis in human umbilical vein endothelial cells, Li-Chun Zheng, Xiao-Qing Wang, Kun Lu, Xiao-Ling Deng, Cheng-Wei Zhang, Hong Luo, Xu-Dong Xu, Xiao-Man Chen, Lu Yan, Yi-Qing Wang, Song-Lin Shi, 2017
- Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6, Guo-Yan Liu, Jing-Xian Shi, Song-Lin Shi, Fan Liu, Gang Rui, Xiao Li, Li-Bin Gao, Xiao-Ling Deng and Qi-Fu Li, 2017
- Relocation of NPM Affects the Malignant Phenotypes of Hepatoma SMMC-7721 Cells, Xiao Li, Dong-Hui Xu, Fan Liu, Guo-Yan Liu, Kun Lu, Xiao-Ling Deng, Qi-Fu Li, Song-Lin Shi, 2017
- Sustainable inflammation transforms hepatic cells by causing oxidative stress injury and potential epithelial-mesenchymal transition, Kun Lu, Guoyan Liu, Ling Yang, Fan Liu, Libin Gao, Jingxian Shi, Xiaoling Deng, Qifu Li, Donghui Xu, Songlin Shi, 2016
- Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells, Bo Peng, Fan Liu, Rong Han, George Luo, Terry Cathopoulis, Kun Lu, Xiao Li, Ling Yang, Guo-Yan Liu, Jian-Chun Cai, Song-Lin Shi, 2015
- Regulatory role of nucleophosmin during the differentiation of human liver cancer cells, Dong-Hui Xu, Fan Liu, Xiao Li, Xiang-Feng Chen, Guang-Jun Jing, Fu-Yun Wu, Song-Lin Shi, Qi-Fu Li, 2014
- 热休克蛋白70在人食管癌EC9706细胞凋亡过程中的表达与定位变化, 刘凡, 陈兰英, 黄建, 刘用金, 石松林, 2012
- Prohibitin在姜黄素诱导人成骨肉瘤MG-63细胞凋亡过程中的调控机制, 石松林, 赵振利, 王国红, 刘凡, 路锟, 杨玲, 韩荣, 李晓, 李祺福, 2015
- 姜黄素诱导人食管癌EC9706细胞凋亡过程中核磷蛋白的表达与定位变化, 石松林, 陈兰英, 刘用金, 杨海波, 路锟, 杨玲, 李祺福, 2014
- The Localization of hnRNP A2/B1 in Nuclear Matrix and the Aberrant Expression During the RA-Induced Differentiation of Human Neuroblastoma SK-N-SH Cells, Liang, Ying, Shi, Song-Lin, Li, Qi-Fu, Chen, Lan-Ying, Jing, Guang-Jun, Tan, Guo-Wei, Wang, San-Ying, Wu, Fu-Yun, 2011
- Synthesis and characterization of a novel cationic polymer gene delivery vector, Shi, Song-Lin, Dan, Bing, Liu, Fan, Lin, Li-Rong, Fu, Zuo-Gen, Jing, Guang-Jun, Yang, Tian-Ci, Zhang, Zhong-Ying, 2010
- Localization of Nucleophosmin in Nuclear Matrix and Changes in Its Expression During the Differentiation of Human Neuroblastoma Induced by Retinoic Acid, Shi, Song-Lin, Liang, Ying, Li, Qi-Fu, Liu, Qing-Rong, Jing, Guang-Jun, Wang, San-Ying, Zhang, Xiu-Yan, Wu, Fu-Yun, 2010
- Nuclear Matrix Protein, Prohibitin, Was Down-Regulated and Translocated From Nucleus to Cytoplasm During the Differentiation of Osteosarcoma MG-63 Cells Induced by Ginsenoside Rg1. Cinnamic acid, and Tanshinone IIA (RCT), Shi, Song-Lin, Li, Qi-Fu, Liu, Qing-Rong, Xu, Dong-Hui, Tang, Jian, Liang, Ying, Zhao, Zhen-Li, Yang, Li-Ming, 2009
- 人参皂甙Rg1对人成骨肉瘤MG-63细胞形态结构和终末分化指标的影响, 石松林, 王国红, 马宗源, 史建陆, 林昌健, 李祺福, 2009
- 文昌鱼鳃组织原代培养, 石松林, 黄晓明, 李祺福, 王三英, 杨海波, 2009
- 人参皂苷Rg1组合诱导人成骨肉瘤MG-63细胞分化过程中Prohibitin的表达与定位变化, 石松林, 李祺福, 刘庆榕, 许东辉, 唐剑, 梁盈, 2008
- 人参皂甙Rg1、肉桂酸和丹参酮IIA组合对成骨肉瘤MG-63细胞增殖与相关基因表达的影响, 石松林, 李祺福, 王国红, 马宗源, 林昌健, 赵振利, 2008
- 人参皂甙Rg1组合对人成骨肉瘤MG-63细胞分化过程中核基质构型与蛋白质组成的影响, 石松林, 李祺福, 郑燕彬, 唐剑, 陈平, 2008
- 丹参酮IIA对人成骨肉瘤MG-63细胞形态结构和终末分化指标的影响, 石松林, 王国红, 马宗源, 史建陆, 林昌健, 李祺福, 2008
- Effects of tachypiesin and n-sodium butyrate on proliferation and gene expression of human gastric adenocarcinoma cell line BGC-823, Shi, Song-Lin, Wang, Yong-Ye, Liang, Ying, Li, Qi-Fu, 2006
Awards
- Fujian Province High-Level Talent
- Xiamen City High-Level Talent
