Professor | Zhanghua Yang | Asia Growth Partners

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Name	Zhanghua Yang
Contact Information	zhanghua_young@xmu.edu.cn
Language ability	Chinese, English
Province	Fujian

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Name

Zhanghua Yang

Contact Information

zhanghua_young@xmu.edu.cn

Language ability

Chinese, English

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Medical
Academic Background & Achievements	2007-2011 Bachelor of Science: Xiamen University, School of Life Sciences 2011-2016 Doctor of Science: Xiamen University, School of Life Sciences
Work Experience	2016-2020 - Xiamen University, School of Life Sciences - Postdoctoral Researcher 2020-2021 - Xiamen University, School of Medicine - Postdoctoral Researcher 2021-present - Xiamen University, School of Medicine - Assistant Professor
Awards	2018-2020: National Natural Science Foundation of China, Youth Science Fund Project 2019-2021: China Postdoctoral Science Foundation, 11th Special Grant 2017-2018: China Postdoctoral Science Foundation, 61st General Grant

University/Lab Affiliation and Title

Xiamen University

Faculty

Medical

Academic Background & Achievements

2007-2011 Bachelor of Science: Xiamen University, School of Life Sciences
2011-2016 Doctor of Science: Xiamen University, School of Life Sciences

Work Experience

2016-2020 - Xiamen University, School of Life Sciences - Postdoctoral Researcher
2020-2021 - Xiamen University, School of Medicine - Postdoctoral Researcher
2021-present - Xiamen University, School of Medicine - Assistant Professor

Awards

2018-2020: National Natural Science Foundation of China, Youth Science Fund Project
2019-2021: China Postdoctoral Science Foundation, 11th Special Grant
2017-2018: China Postdoctoral Science Foundation, 61st General Grant

Areas of Focus	Regulation mechanisms of necroptosis and pyroptosis in inflammatory cell death and their roles in physiological and pathological processes
Publications	Detection of necroptosis by phospho-MLKL immunohistochemical labeling, He P, Ai T, Yang ZH, Wu J, Han J, 2021 RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes, Li X, Zhong CQ, Wu R, Xu X, Yang ZH, Cai S, Wu X, Chen X, Yin Z, He Q, Li D, Xu F, Yan Y, Qi H, Xie C, Shuai J, Han J, 2021 A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade, Yang ZH, Wu XN, He P, Wang X, Wu J, Ai T, Zhong CQ, Wu X, Cong Y, Zhu R, Li H, Cai ZY, Mo W, Han J, 2020 Gut stem cell necroptosis by genome instability triggers bowel inflammation, Wang R, Li H, Wu J, Cai ZY, Li B, Ni H, Qiu X, Chen H, Liu W, Yang ZH, Liu M, Hu J, Liang Y, Lan P, Han J, Mo W, 2020 Quantification of Dynamic Protein Interactions and Phosphorylation in LPS Signaling Pathway by SWATH-MS, Wu X, Yang D, Zhao F, Yang ZH, Wang D, Qiao M, Fang Y, Li W, Wu R, He P, Cong Y, Chen C, Hu L, Yan Y, Xie C, Wu Y, Han J, Zhong CQ, 2019 RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome, Zhang Y, Su SS, Zhao S, Yang Z, Zhong CQ, Chen X, Cai Q, Yang ZH, Huang D, Wu R, Han J, 2017 Gasdermin D is an executor of pyroptosis and required for interleukin-1 beta secretion, He W, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J, 2015 Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis, Wu XN, Yang ZH, Wang XK, Zhang Y, Wan H, Song Y, Chen X, Shao J, Han J, 2014

Areas of Focus

Regulation mechanisms of necroptosis and pyroptosis in inflammatory cell death and their roles in physiological and pathological processes

Publications

Detection of necroptosis by phospho-MLKL immunohistochemical labeling, He P, Ai T, Yang ZH, Wu J, Han J, 2021
RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes, Li X, Zhong CQ, Wu R, Xu X, Yang ZH, Cai S, Wu X, Chen X, Yin Z, He Q, Li D, Xu F, Yan Y, Qi H, Xie C, Shuai J, Han J, 2021
A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade, Yang ZH, Wu XN, He P, Wang X, Wu J, Ai T, Zhong CQ, Wu X, Cong Y, Zhu R, Li H, Cai ZY, Mo W, Han J, 2020
Gut stem cell necroptosis by genome instability triggers bowel inflammation, Wang R, Li H, Wu J, Cai ZY, Li B, Ni H, Qiu X, Chen H, Liu W, Yang ZH, Liu M, Hu J, Liang Y, Lan P, Han J, Mo W, 2020
Quantification of Dynamic Protein Interactions and Phosphorylation in LPS Signaling Pathway by SWATH-MS, Wu X, Yang D, Zhao F, Yang ZH, Wang D, Qiao M, Fang Y, Li W, Wu R, He P, Cong Y, Chen C, Hu L, Yan Y, Xie C, Wu Y, Han J, Zhong CQ, 2019
RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome, Zhang Y, Su SS, Zhao S, Yang Z, Zhong CQ, Chen X, Cai Q, Yang ZH, Huang D, Wu R, Han J, 2017
Gasdermin D is an executor of pyroptosis and required for interleukin-1 beta secretion, He W, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J, 2015
Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis, Wu XN, Yang ZH, Wang XK, Zhang Y, Wan H, Song Y, Chen X, Shao J, Han J, 2014

Necroptosis Pyroptosis Inflammation Cell Death Regulation Physiological Pathological Mechanisms Processes Roles

Francis Kaming Chan - Zhejiang University

Jian Zou - Zhejiang University

Zhexu Chi - Zhejiang University

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