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Yanwei Sha
Medical School
Xiamen University
Fujian
Language: Chinese, English
Azoospermia
Oligospermia
Asthenozoospermia
Teratozoospermia
Pathogenic Genes
Molecular Mechanisms
Sperm Membrane
Receptor Abnormalities
Fertilization Failure
Embryonic Development
Areas of Focus
- Pathogenic genes and molecular mechanisms of azoospermia, oligospermia, asthenozoospermia, and teratozoospermia
- Pathogenic genes and molecular mechanisms of sperm membrane and receptor abnormalities leading to fertilization failure
- Pathogenic genes and molecular mechanisms of early embryonic development arrest
- Research on genetic testing technology for prevention and treatment of recurrent spontaneous abortion and preimplantation embryos
Work Experience
- 2020-present - Xiamen University Affiliated Women and Children's Hospital - Associate Professor
- 2016-present - Xiamen Maternal and Child Health Hospital - Deputy Chief Physician
- 2012-2016 - Xiamen Maternal and Child Health Hospital - Attending Physician
- 2006-2012 - Xiamen Maternal and Child Health Hospital - Resident Physician
Academic Background & Achievements
- 2002-2005 Master's Degree: Jilin University
- 2000-2002 Clinical Medicine: Jilin University Bethune Medical Department
Publications
- Defective piRNA Processing and Azoospermia, Sha Y, Li L, Yin C, 2022
- Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice, Tan C, Meng L, Lv M, He X, Sha Y, Tang D, Tan Y, Hu T, He W, Tu C, Nie H, Zhang H, Du J, Lu G, Fan LQ, Cao Y, Lin G, Tan YQ, 2022
- Biallelic mutations in ARMC12 cause asthenozoospermia and multiple midpiece defects in humans and mice, Liu W, Wei X, Liu X, Chen G, Zhang X, Liang X, Isachenko V, Sha Y, Wang Y, 2022
- DNAH1 gene mutations and their potential association with dysplasia of the sperm fibrous sheath and infertility in the Han Chinese population, Sha Y, Yang X, Mei L, Ji Z, Wang X, Ding L, Li P, Yang S, 2017
- Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility, Liu C, Miyata H, Gao Y, Sha Y, Tang S, Xu Z, Whitfield M, Patrat C, Wu H, Dulioust E, Tian S, Shimada K, Cong J, Noda T, Li H, Morohoshi A, Cazin C, Kherraf ZE, Arnoult C, Jin L, He X, Ray PF, Cao Y, Touré A, Zhang F, Ikawa M, 2020
- Biallelic mutations of CFAP74 may cause human primary ciliary dyskinesia and MMAF phenotype, Sha Y, Wei X, Ding L, Ji Z, Mei L, Huang X, Su Z, Wang W, Zhang X, Lin S, 2020
- Loss-of-function mutations in SPEF2 cause multiple morphological abnormalities of the sperm flagella (MMAF), Liu W, Sha Y, Li Y, Mei L, Lin S, Huang X, Lu J, Ding L, Kong S, Lu Z, 2019
- Biallelic mutations in PMFBP1 cause acephalic spermatozoa, Sha YW, Wang X, Xu X, Ding L, Liu WS, Li P, Su ZY, Chen J, Mei LB, Zheng LK, Wang HL, Kong SB, You M, Wu JF, 2019
Awards
- Fujian High-Level Talent (2021)
- National Women's and Children's Health Science and Technology Third Prize (2020)
- Xiamen Science and Technology Progress Award Third Prize (2020)
- Fujian Medical Science and Technology Progress Second Prize (2019)
- National Women's and Children's Health Science and Technology Third Prize (2019)
- Xiamen Science and Technology Progress Award Second Prize (2019)
- Xiamen Science and Technology Progress Award Second Prize (2017)
- National Women's and Children's Health Science and Technology Second Prize (2017)
- Xiamen Medical Innovation Award (2015)
