Areas of Focus
- Cell Biology
- Genetics
- Biochemistry
- Molecular Biology
Work Experience
- 2000-2008 Postdoctoral Researcher: National Institutes of Health, USA
- 2008-Present Professor, Doctoral Supervisor: Tsinghua University
Academic Background & Achievements
- 1990-1994 Bachelor: Sichuan University
- 1994-1997 Master: Yunnan University
- 1997-2000 PhD: Peking University
Publications
- The formation of migrasomes is initiated by the assembly of sphingomyelin synthase 2 foci at the leading edge of migrating cells, Li Yu et al., 2023
- The phosphatidylinositol (4,5)-bisphosphate-Rab35 axis regulates migrasome formation, Li Yu et al.
- Monocytes deposit migrasomes to promote embryonic angiogenesis, Li Yu et al., 2022
- Retractosomes: small extracellular vesicles generated from broken-off retraction fibers, Li Yu et al.
- Assembly of Tetraspanin-enriched macrodomains contains membrane damage to facilitate repair, Li Yu et al., 2022
- Mitocytosis, a migrasome-mediated mitochondrial quality-control process, Li Yu et al., 2021
- Iterative tomography with digital adaptive optics permits hour-long intravital observation of 3D subcellular dynamics at millisecond scale, Li Yu et al., 2021
- Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells, Li Yu et al.
- Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation, Li Yu et al., 2019
- Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains, Li Yu et al., 2019
- Pairing of integrins with ECM proteins determines migrasome formation, Li Yu et al.
- CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane, Li Yu et al., 2015
- Discovery of the migrasome, an organelle mediates release of cytoplasmic contents during cell migration, Li Yu et al., 2015
- Clathrin and phosphatidylinositol 4,5-bisphosphate regulate autophagic lysosome reformation, Li Yu et al., 2012
- Function and Molecular Mechanism of Acetylation in Autophagy Regulation, Li Yu et al., 2012
Awards
- 2012: Top Ten Scientific Advances in China for revealing molecular mechanisms of autophagy under nutrient deficiency
- 2013: Sixth Tan Jiazhen Life Science Innovation Award
- 2016: Young Science and Technology Innovation Leader in the Innovation Talent Promotion Plan
- 2021: Outstanding Achievement Award from the Chinese Society for Cell Biology
