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Personal Information

Li Yu
liyulab@mail.tsinghua.edu.cn
Chinese, English
Beijing

Academic Information

Tsinghua University
Life Sciences
  • 1990-1994 Bachelor: Sichuan University
  • 1994-1997 Master: Yunnan University
  • 1997-2000 PhD: Peking University
  • 2000-2008 Postdoctoral Researcher: National Institutes of Health, USA
  • 2008-Present Professor, Doctoral Supervisor: Tsinghua University
  • 2012: Top Ten Scientific Advances in China for revealing molecular mechanisms of autophagy under nutrient deficiency
  • 2013: Sixth Tan Jiazhen Life Science Innovation Award
  • 2016: Young Science and Technology Innovation Leader in the Innovation Talent Promotion Plan
  • 2021: Outstanding Achievement Award from the Chinese Society for Cell Biology

Research

Cell Biology
Genetics
Biochemistry
Molecular Biology
  • The formation of migrasomes is initiated by the assembly of sphingomyelin synthase 2 foci at the leading edge of migrating cells, Li Yu et al., 2023
  • The phosphatidylinositol (4,5)-bisphosphate-Rab35 axis regulates migrasome formation, Li Yu et al.
  • Monocytes deposit migrasomes to promote embryonic angiogenesis, Li Yu et al., 2022
  • Retractosomes: small extracellular vesicles generated from broken-off retraction fibers, Li Yu et al.
  • Assembly of Tetraspanin-enriched macrodomains contains membrane damage to facilitate repair, Li Yu et al., 2022
  • Mitocytosis, a migrasome-mediated mitochondrial quality-control process, Li Yu et al., 2021
  • Iterative tomography with digital adaptive optics permits hour-long intravital observation of 3D subcellular dynamics at millisecond scale, Li Yu et al., 2021
  • Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells, Li Yu et al.
  • Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation, Li Yu et al., 2019
  • Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains, Li Yu et al., 2019
  • Pairing of integrins with ECM proteins determines migrasome formation, Li Yu et al.
  • CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane, Li Yu et al., 2015
  • Discovery of the migrasome, an organelle mediates release of cytoplasmic contents during cell migration, Li Yu et al., 2015
  • Clathrin and phosphatidylinositol 4,5-bisphosphate regulate autophagic lysosome reformation, Li Yu et al., 2012
  • Function and Molecular Mechanism of Acetylation in Autophagy Regulation, Li Yu et al., 2012
Keywords
Cell Organelles Migrasome Mechanisms Functions Model Organisms Cell Migration Membrane Dynamics Signal Transduction Protein Synthesis Gene Expression
Related Professors
Jinwei Zhu - Shanghai Jiao Tong University
Area of Focus
Neural | Signal Transduction | Plasticity | Biochemistry | Structural Biology | Glomerular Filtration | Cell Connections | Cell Polarity | Cell Migration | Synaptic Development
Yi Deng - Southern University of Science and Technology
Area of Focus
Cell Microenvironment | Signal Transduction | Disease | Cell-Matrix Adhesion | Actin Cytoskeleton | Cell Migration | Embryonic Development | Tumor Metastasis | Integrin Signaling | Molecular Mechanisms
Li Yu - Tsinghua University
Area of Focus
Cell Organelles | Migrasome | Cell Migration | Sphingomyelin Synthase | Phosphatidylinositol | Rab35 | Extracellular Vesicles | Membrane Repair | Mitochondrial Quality Control | Autophagy
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