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Li Yu
liyulab@mail.tsinghua.edu.cn
Chinese, English
Beijing

Academic Information

Tsinghua University
Life Sciences
  • 1990-1994 Bachelor: Sichuan University
  • 1994-1997 Master: Yunnan University
  • 1997-2000 PhD: Peking University
  • 2000-2008 Postdoctoral Researcher: National Institutes of Health, USA
  • 2008-Present - Tsinghua University, School of Life Sciences - Professor, Doctoral Supervisor
  • 2012: Top Ten Scientific Advances in China for revealing molecular mechanisms of autophagy induced by nutrient deficiency
  • 2013: Sixth Tan Jiazhen Life Science Innovation Award
  • 2016: Young and Middle-aged Science and Technology Innovation Leading Talent
  • 2021: Outstanding Achievement Award from the Chinese Society for Cell Biology

Research

Cell Biology
Genetics
Biochemistry
Molecular Biology
  • The formation of migrasomes is initiated by the assembly of sphingomyelin synthase 2 foci at the leading edge of migrating cells, Haisha Liang, Xinyu Ma, Yuanyuan Zhang, Yuheng Liu, Nan Liu, Weiying Zhang, Jianhui Chen, Boqi Liu, Wanqing Du, Xiaohui Liu and Li Yu, 2023
  • The phosphatidylinositol (4,5)-bisphosphate-Rab35 axis regulates migrasome formation, Tianlun Ding, Jinyao Ji, Weiying Zhang, Yuheng Liu, Boqi Liu, Yiyang Han, Chunlai Chen, Li Yu
  • Monocytes deposit migrasomes to promote embryonic angiogenesis, Cuifang Zhang, Tianqi Li, Shuyao Yin, Mingyi Gao, Helen He, Ying Li, Dong Jiang, Minghui Shi, Jianbin Wang and Li Yu, 2022
  • Retractosomes: small extracellular vesicles generated from broken-off retraction fibers, Yizheng Wang, Shuaixin Gao, Yuheng Liu, Dongju Wang, Boqi Liu, Dong Jiang, Catherine C. L. Wong, Yang Chen, Li Yu
  • Assembly of Tetraspanin-enriched macrodomains contains membrane damage to facilitate repair, Yuwei Huang, Xing Zhang, Hong-Wei Wang, Li Yu, 2022
  • Mitocytosis, a migrasome-mediated mitochondrial quality-control process, Haifeng Jiao, Dong Jiang, Xiaoyu Hu, Wanqing Du, Liangliang Ji, Yuzhuo Yang, Xiaopeng Li, Takami Sho, Xuan Wang, Ying Li, Yu-Ting Wu, Yau-Huei Wei, Xiaoyu Hu, and Li Yu, 2021
  • Iterative tomography with digital adaptive optics permits hour-long intravital observation of 3D subcellular dynamics at millisecond scale, Jiamin Wu, Zhi Lu, Dong Jiang, Yuduo Guo, Hui Qiao, Yi Zhang, Tianyi Zhu, Yeyi Cai, Xu Zhang, Karl Zhanghao, Hao Xie, Tao Yan, Guoxun Zhang, Xiaoxu Li, Zheng Jiang, Xing Lin, Lu Fang, Bing Zhou, Peng Xi, Jingtao Fan, Li Yu, and Qionghai Dai, 2021
  • Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells, Mingli Zhu, Qin Zou, Rongyao Huang, Ying Li, Xudong Xing, Jianhuo Fang, Liang Ma, Lifei Li, Xuerui Yang, and Li Yu
  • Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation, DongJiang, Zheng Jiang, Di Lu, Xuan Wang, Haisha Liang, Junfeng Zhang, Yaping Meng, Ying Li, Danni Wu, Yuwei Huang, Yuling Chen, Haiteng Deng, Qing Wu, Jingwei Xiong, Anming Meng, and Li Yu, 2019
  • Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains, Yuwei Huang, Ben Zucker, Shaojin Zhang, Sharon Elias, Yun Zhu, Hui Chen, Tianlun Ding, Ying Li, Yujie Sun, Jizhong Lou, Michael M.Kozlov, and Li Yu, 2019
  • Pairing of integrins with ECM proteins determines migrasome formation, Danni Wu, Yue Xu, Ding, Tianlun Ding, Yan Zu, Chun Yang, and Li Yu
  • CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane, Na Mi, Yang Chen, Shuai Wang, Mengran Chen, Mingkun Zhao, Guang Yang, Meisheng Ma, Qian Su, Sai Luo, Jingwen Shi, Jia Xu, Qiang Guo, Ning Gao, Yujie Sun, Zhucheng Chen, and Li Yu, 2015
  • Discovery of the migrasome, an organelle mediates release of cytoplasmic contents during cell migration, Liang Ma, Ying Li, Junya Peng, Danni Wu, Xiaoxin Zhao, Yitong Cui, Lilian Chen, Xiaojun Yan, Yanan Du, and Li Yu, 2015
  • Clathrin and phosphatidylinositol 4,5-bisphosphate regulate autophagic lysosome reformation, Yueguang Rong, Mei Liu, Liang Ma, Wanqing Du, Hanshuo Zhang, Yuan Tian, Zhen Cao, Ying Li, He Ren, Chuanmao Zhang, Lin Li, She Chen, Jianzhong Xi, and Li Yu, 2012
  • Function and Molecular Mechanism of Acetylation in Autophagy Regulation, Cong Yi, Meisheng Ma, Leili Ran, Jingxiang Zheng, Jingjing Tong, Jing Zhu, Chengying Ma, Yufen Sun, Shaojin Zhang, Wenzhi Feng, Liyuan Zhu, Yan Le, Xingqi Gong, Xianghua Yan, Bing Hong, Fen-Jun Jiang, Zhiping Xie, Di Miao, Haiteng Deng, and Li Yu, 2012
Keywords
Cell Organelles Migrasome Cell Migration Sphingomyelin Synthase Phosphatidylinositol Rab35 Extracellular Vesicles Membrane Repair Mitochondrial Quality Control Autophagy
Related Professors
Li Yu - Tsinghua University
Area of Focus
Cell Organelles | Migrasome | Mechanisms | Functions | Model Organisms | Cell Migration | Membrane Dynamics | Signal Transduction | Protein Synthesis | Gene Expression
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