Professor | Jiang Peng | Asia Growth Partners

Name	Jiang Peng
Contact Information	jiang-lab@mail.tsinghua.edu.cn
Language ability	English, Chinese
Province	Beijing

Name

Jiang Peng

Contact Information

jiang-lab@mail.tsinghua.edu.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Tsinghua University
Faculty	Life Sciences
Academic Background & Achievements	1999-2003 Bachelor: Anhui University, Biotechnology 2003-2008 PhD: University of Science and Technology of China, Molecular and Cell Biology Postdoctoral Researcher at University of Pennsylvania School of Medicine
Work Experience	2008-2013 - University of Pennsylvania School of Medicine - Postdoctoral Researcher 2013-2014 - University of Pennsylvania School of Medicine - Research Associate 2014-2021 - Tsinghua University School of Life Sciences - Assistant Professor 2021- - Tsinghua University School of Life Sciences - Associate Professor 2020- - Tsinghua-Peking Joint Center for Life Sciences - Principal Investigator

University/Lab Affiliation and Title

Tsinghua University

Faculty

Life Sciences

Academic Background & Achievements

1999-2003 Bachelor: Anhui University, Biotechnology
2003-2008 PhD: University of Science and Technology of China, Molecular and Cell Biology
Postdoctoral Researcher at University of Pennsylvania School of Medicine

Work Experience

2008-2013 - University of Pennsylvania School of Medicine - Postdoctoral Researcher
2013-2014 - University of Pennsylvania School of Medicine - Research Associate
2014-2021 - Tsinghua University School of Life Sciences - Assistant Professor
2021- - Tsinghua University School of Life Sciences - Associate Professor
2020- - Tsinghua-Peking Joint Center for Life Sciences - Principal Investigator

Areas of Focus	Tumor and immune metabolism
Publications	p53 suppresses lipid droplet-fueled tumorigenesis through phosphatidylcholine, Xu X, Wang J, Xu L, Li P, Jiang P, 2024 AKT1 phosphorylation of cytoplasmic ME2 induces a metabolic switch to glycolysis for tumorigenesis, Chen T, Xie S, Cheng J, Zhao Q, Wu H, Jiang P, Du W, 2024 p53 promotes antiviral innate immunity by driving hexosamine metabolism, Xia W, Jiang P, 2024 Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment, Cheng J, Yan J, Liu Y, Shi J, Wang H, Zhou H, Zhou Y, Zhang T, Zhao L, Meng X, Gong H, Zhang X, Zhu H, Jiang P, 2023 Fumarate suppresses B-cell activation and function through direct inactivation of LYN, Cheng J, Liu Y, Yan J, Zhao L, Zhou Y, Shen X, Chen Y, Meng X, Zhang X, Jiang P, 2022 Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate, Zhao M, Yao P, Mao Y, Wu J, Wang W, Geng C, Cheng J, Du W, Jiang P, 2022 Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses, Mao Y, Shi D, Li G, Jiang P, 2022 p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage, Wu J, Li G, Li L, Jiang P, 2021 Asparagine enhances LCK signalling to potentiate CD8+ T cell-activation and anti-tumour responses, Wu J, Li G, Li L, Li D, Dong Z, Jiang P, 2021 p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival, Deng L, Yao P, Li L, Ji F, Zhao S, Xu C, Lan X, Jiang P, 2020 p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis, Li L, Mao Y, Zhao L, Li L, Wu J, Zhao M, Du W, Yu L, Jiang P, 2019 TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation, Li L, Li L, Li W, Chen T, Bin Zou, Zhao L, Wang H, Wang X, Xu L, Liu X, Wang D, Li B, Mak TW, Du W, Yang X, Jiang P, 2018 TAp73 enhances the pentose phosphate pathway and supports cell proliferation, Du W, Jiang P, Mancuso A, Stonestrom A, Brewer M, Minn AJ, Mak TW, Wu M, Yang X, 2013 Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence, Jiang P, Du W, Wang X, Mancuso A, Gao X, Wu M, Yang X, 2013 p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase, Jiang P, Du W, Wang X, Mancuso A, Gao X, Wu M, Yang X, 2011

Areas of Focus

Tumor and immune metabolism

Publications

p53 suppresses lipid droplet-fueled tumorigenesis through phosphatidylcholine, Xu X, Wang J, Xu L, Li P, Jiang P, 2024
AKT1 phosphorylation of cytoplasmic ME2 induces a metabolic switch to glycolysis for tumorigenesis, Chen T, Xie S, Cheng J, Zhao Q, Wu H, Jiang P, Du W, 2024
p53 promotes antiviral innate immunity by driving hexosamine metabolism, Xia W, Jiang P, 2024
Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment, Cheng J, Yan J, Liu Y, Shi J, Wang H, Zhou H, Zhou Y, Zhang T, Zhao L, Meng X, Gong H, Zhang X, Zhu H, Jiang P, 2023
Fumarate suppresses B-cell activation and function through direct inactivation of LYN, Cheng J, Liu Y, Yan J, Zhao L, Zhou Y, Shen X, Chen Y, Meng X, Zhang X, Jiang P, 2022
Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate, Zhao M, Yao P, Mao Y, Wu J, Wang W, Geng C, Cheng J, Du W, Jiang P, 2022
Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses, Mao Y, Shi D, Li G, Jiang P, 2022
p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage, Wu J, Li G, Li L, Jiang P, 2021
Asparagine enhances LCK signalling to potentiate CD8+ T cell-activation and anti-tumour responses, Wu J, Li G, Li L, Li D, Dong Z, Jiang P, 2021
p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival, Deng L, Yao P, Li L, Ji F, Zhao S, Xu C, Lan X, Jiang P, 2020
p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis, Li L, Mao Y, Zhao L, Li L, Wu J, Zhao M, Du W, Yu L, Jiang P, 2019
TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation, Li L, Li L, Li W, Chen T, Bin Zou, Zhao L, Wang H, Wang X, Xu L, Liu X, Wang D, Li B, Mak TW, Du W, Yang X, Jiang P, 2018
TAp73 enhances the pentose phosphate pathway and supports cell proliferation, Du W, Jiang P, Mancuso A, Stonestrom A, Brewer M, Minn AJ, Mak TW, Wu M, Yang X, 2013
Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence, Jiang P, Du W, Wang X, Mancuso A, Gao X, Wu M, Yang X, 2013
p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase, Jiang P, Du W, Wang X, Mancuso A, Gao X, Wu M, Yang X, 2011

Tumor Immune Metabolism Cellular Mechanisms Molecular Mechanisms Pathophysiology Cd8+ T Cells Microenvironment Metabolites Regulatory Mechanisms

Dan Li - Shanghai Jiao Tong University

Yuan Xiaobing - East China Normal University

Jianbin Wang - Tsinghua University

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