Areas of Focus
- Protein homeostasis, phase separation, and aggregation in neurodegenerative diseases
- Early diagnosis and drug development for Parkinson's disease
Work Experience
- 2017-Present - Shanghai Jiao Tong University, Bio-X Institutes
Academic Background & Achievements
- 1998-2002 Bachelor: Jilin University, College of Life Sciences
- 2002-2008 PhD: Peking University, College of Life Sciences
- 2008-2014 Postdoctoral Researcher: University of California, Los Angeles
Publications
- Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology, Tao Y.Q., Sun Y.P., Lv S.R., Xia W.C., Zhao K., Xu Q.H., Zhao Q.Y., He L., Wang Y., Liu C.*, Li D.*, 2022
- Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia, Long H.F., Zhang S.N., Zeng S.Y., Tong Y.L., Liu J., Liu C.*, Li D.*, 2022
- Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases, Li D*, Liu C*., 2022
- Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders, Fan Y, Zhao Q, Xia W, Tao Y, Yu W, Chen M, Liu Y, Zhao J, Shen Y, Sun Y, Si C, Zhang S, Zhang Y, Li W, Liu C, Wang J*, Li D*., 2022
- Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease, Dan Li and Cong Liu, 2021
- The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure, Yunpeng Sun#, Kun Zhao#, Wencheng Xia, Jinge Gu, Yeyang Ma, Xinrui Gui, Xia Zhang, Yanshan Fang, Bo Sun, Cong Liu*, Dan Li*, 2020
- Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles, Jinge Gu , Zhenying Liu , Shengnan Zhang , Yichen Li , Wencheng Xia , Chen Wang , Huaijiang Xiang , Zhijun Liu , Li Tan , Yanshan Fang , Cong Liu* , Dan Li*, 2020
- Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure, Zhao, K., Li, Y., Liu, Z., Long, H., Zhao, C., Luo, F., Sun, Y., Tao, Y., Su, X.-D., Li, D.#, Li, X.#, Liu, C.#, 2020
- Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly, Gui, X., Luo, F., Li, YC, Zhou, H., Qin,Z., Liu, ZY, Gu, JG, Xie, MY, Zhao, K., Dai, B., Shin, WS, He, JH, He, L., Jiang, L., Zhao, ML, Sun, B., Li, XM, Liu, C.#, Li, D.#, 2019
- Better together: a hybrid amyloid signals necroptosis, Li, D.#, Liu, C.#, 2018
Awards
- 2018: Shanghai Pujiang Talent Plan
- 2019: Shanghai Universities Specially Appointed Professor (Eastern Scholar)
- 2020: National Ten Thousand Talent Program for Young Top-Notch Talent
