Professor | Dan Li | Asia Growth Partners

Name	Dan Li
Contact Information	lidan2017@sjtu.edu.cn
Language ability	English, Chinese
Province	Shanghai

Name

Dan Li

Contact Information

lidan2017@sjtu.edu.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	Shanghai Jiao Tong University
Faculty	Life Sciences
Academic Background & Achievements	1998-2002 Bachelor: Jilin University, College of Life Sciences 2002-2008 PhD: Peking University, College of Life Sciences 2008-2014 Postdoctoral Researcher: University of California, Los Angeles
Work Experience	2017-Present - Shanghai Jiao Tong University, Bio-X Institutes
Awards	2018: Shanghai Pujiang Talent Plan 2019: Shanghai Universities Specially Appointed Professor (Eastern Scholar) 2020: National Ten Thousand Talent Program for Young Top-Notch Talent

University/Lab Affiliation and Title

Shanghai Jiao Tong University

Faculty

Life Sciences

Academic Background & Achievements

1998-2002 Bachelor: Jilin University, College of Life Sciences
2002-2008 PhD: Peking University, College of Life Sciences
2008-2014 Postdoctoral Researcher: University of California, Los Angeles

Work Experience

2017-Present - Shanghai Jiao Tong University, Bio-X Institutes

Awards

2018: Shanghai Pujiang Talent Plan
2019: Shanghai Universities Specially Appointed Professor (Eastern Scholar)
2020: National Ten Thousand Talent Program for Young Top-Notch Talent

Areas of Focus	Protein homeostasis, phase separation, and aggregation in neurodegenerative diseases Early diagnosis and drug development for Parkinson's disease
Publications	Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology, Tao Y.Q., Sun Y.P., Lv S.R., Xia W.C., Zhao K., Xu Q.H., Zhao Q.Y., He L., Wang Y., Liu C., Li D., 2022 Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia, Long H.F., Zhang S.N., Zeng S.Y., Tong Y.L., Liu J., Liu C., Li D., 2022 Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases, Li D, Liu C., 2022 Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders, Fan Y, Zhao Q, Xia W, Tao Y, Yu W, Chen M, Liu Y, Zhao J, Shen Y, Sun Y, Si C, Zhang S, Zhang Y, Li W, Liu C, Wang J, Li D., 2022 Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease, Dan Li and Cong Liu, 2021 The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure, Yunpeng Sun#, Kun Zhao#, Wencheng Xia, Jinge Gu, Yeyang Ma, Xinrui Gui, Xia Zhang, Yanshan Fang, Bo Sun, Cong Liu, Dan Li, 2020 Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles, Jinge Gu , Zhenying Liu , Shengnan Zhang , Yichen Li , Wencheng Xia , Chen Wang , Huaijiang Xiang , Zhijun Liu , Li Tan , Yanshan Fang , Cong Liu* , Dan Li*, 2020 Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure, Zhao, K., Li, Y., Liu, Z., Long, H., Zhao, C., Luo, F., Sun, Y., Tao, Y., Su, X.-D., Li, D.#, Li, X.#, Liu, C.#, 2020 Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly, Gui, X., Luo, F., Li, YC, Zhou, H., Qin,Z., Liu, ZY, Gu, JG, Xie, MY, Zhao, K., Dai, B., Shin, WS, He, JH, He, L., Jiang, L., Zhao, ML, Sun, B., Li, XM, Liu, C.#, Li, D.#, 2019 Better together: a hybrid amyloid signals necroptosis, Li, D.#, Liu, C.#, 2018

Areas of Focus

Protein homeostasis, phase separation, and aggregation in neurodegenerative diseases
Early diagnosis and drug development for Parkinson's disease

Publications

Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology, Tao Y.Q., Sun Y.P., Lv S.R., Xia W.C., Zhao K., Xu Q.H., Zhao Q.Y., He L., Wang Y., Liu C.*, Li D.*, 2022
Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia, Long H.F., Zhang S.N., Zeng S.Y., Tong Y.L., Liu J., Liu C.*, Li D.*, 2022
Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases, Li D*, Liu C*., 2022
Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders, Fan Y, Zhao Q, Xia W, Tao Y, Yu W, Chen M, Liu Y, Zhao J, Shen Y, Sun Y, Si C, Zhang S, Zhang Y, Li W, Liu C, Wang J*, Li D*., 2022
Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease, Dan Li and Cong Liu, 2021
The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure, Yunpeng Sun#, Kun Zhao#, Wencheng Xia, Jinge Gu, Yeyang Ma, Xinrui Gui, Xia Zhang, Yanshan Fang, Bo Sun, Cong Liu*, Dan Li*, 2020
Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles, Jinge Gu , Zhenying Liu , Shengnan Zhang , Yichen Li , Wencheng Xia , Chen Wang , Huaijiang Xiang , Zhijun Liu , Li Tan , Yanshan Fang , Cong Liu* , Dan Li*, 2020
Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure, Zhao, K., Li, Y., Liu, Z., Long, H., Zhao, C., Luo, F., Sun, Y., Tao, Y., Su, X.-D., Li, D.#, Li, X.#, Liu, C.#, 2020
Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly, Gui, X., Luo, F., Li, YC, Zhou, H., Qin,Z., Liu, ZY, Gu, JG, Xie, MY, Zhao, K., Dai, B., Shin, WS, He, JH, He, L., Jiang, L., Zhao, ML, Sun, B., Li, XM, Liu, C.#, Li, D.#, 2019
Better together: a hybrid amyloid signals necroptosis, Li, D.#, Liu, C.#, 2018

Protein Homeostasis Phase Separation Aggregation Neurodegenerative Diseases Cell Function Protein Aggregation Cell Death Biomolecular Assemblies Membraneless Organelles Pathological Aggregation Parkinson'S Disease Drug Development Early Diagnosis Molecular Mechanisms Cellular Mechanisms Tissue-Level Progression Complex Neural Systems Disease Mechanisms Therapeutic Approaches

Xiaofang Li - East China Normal University

Dan Li - Shanghai Jiao Tong University

Xiaofang Li - East China Normal University

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