Professor | 李丹 | 数字化转型顾问

Name	李丹
Contact Information	lidan2017@sjtu.edu.cn
Language ability	英语, 汉语
Province	上海

Name

李丹

Contact Information

lidan2017@sjtu.edu.cn

Language ability

英语, 汉语

Province

上海

University/Lab Affiliation and Title	上海交通大学
Faculty	Life Sciences
Academic Background & Achievements	1998-2002 学士: 吉林大学生命科学学院 2002-2008 博士: 北京大学生命科学学院 2008-2014 博士后: 美国加州大学洛杉矶分校
Work Experience	2017年至今 - 上海交通大学Bio-X研究院
Awards	2018年: 上海市浦江人才计划 2019年: 上海高校特聘教授(东方学者) 2020年: 中组部万人计划青年拔尖

University/Lab Affiliation and Title

上海交通大学

Faculty

Life Sciences

Academic Background & Achievements

1998-2002 学士: 吉林大学生命科学学院
2002-2008 博士: 北京大学生命科学学院
2008-2014 博士后: 美国加州大学洛杉矶分校

Work Experience

2017年至今 - 上海交通大学Bio-X研究院

Awards

2018年: 上海市浦江人才计划
2019年: 上海高校特聘教授(东方学者)
2020年: 中组部万人计划青年拔尖

Areas of Focus	神经退行性疾病中蛋白质稳态调控、分相和聚集帕金森病早期诊断和药物开发
Publications	Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology, Tao Y.Q., Sun Y.P., Lv S.R., Xia W.C., Zhao K., Xu Q.H., Zhao Q.Y., He L., Wang Y., Liu C., Li D., 2022 Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia, Long H.F., Zhang S.N., Zeng S.Y., Tong Y.L., Liu J., Liu C., Li D., 2022 Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases, Li D, Liu C., 2022 Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders, Fan Y, Zhao Q, Xia W, Tao Y, Yu W, Chen M, Liu Y, Zhao J, Shen Y, Sun Y, Si C, Zhang S, Zhang Y, Li W, Liu C, Wang J, Li D., 2022 Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease, Dan Li and Cong Liu, 2021 The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure, Yunpeng Sun#, Kun Zhao#, Wencheng Xia, Jinge Gu, Yeyang Ma, Xinrui Gui, Xia Zhang, Yanshan Fang, Bo Sun, Cong Liu, Dan Li, 2020 Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles, Jinge Gu , Zhenying Liu , Shengnan Zhang , Yichen Li , Wencheng Xia , Chen Wang , Huaijiang Xiang , Zhijun Liu , Li Tan , Yanshan Fang , Cong Liu* , Dan Li*, 2020 Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure, Zhao, K., Li, Y., Liu, Z., Long, H., Zhao, C., Luo, F., Sun, Y., Tao, Y., Su, X.-D., Li, D.#, Li, X.#, Liu, C.#, 2020 Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly, Gui, X., Luo, F., Li, YC, Zhou, H., Qin,Z., Liu, ZY, Gu, JG, Xie, MY, Zhao, K., Dai, B., Shin, WS, He, JH, He, L., Jiang, L., Zhao, ML, Sun, B., Li, XM, Liu, C.#, Li, D.#, 2019 Better together: a hybrid amyloid signals necroptosis, Li, D.#, Liu, C.#, 2018

Areas of Focus

神经退行性疾病中蛋白质稳态调控、分相和聚集
帕金森病早期诊断和药物开发

Publications

Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology, Tao Y.Q., Sun Y.P., Lv S.R., Xia W.C., Zhao K., Xu Q.H., Zhao Q.Y., He L., Wang Y., Liu C.*, Li D.*, 2022
Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia, Long H.F., Zhang S.N., Zeng S.Y., Tong Y.L., Liu J., Liu C.*, Li D.*, 2022
Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases, Li D*, Liu C*., 2022
Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders, Fan Y, Zhao Q, Xia W, Tao Y, Yu W, Chen M, Liu Y, Zhao J, Shen Y, Sun Y, Si C, Zhang S, Zhang Y, Li W, Liu C, Wang J*, Li D*., 2022
Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease, Dan Li and Cong Liu, 2021
The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure, Yunpeng Sun#, Kun Zhao#, Wencheng Xia, Jinge Gu, Yeyang Ma, Xinrui Gui, Xia Zhang, Yanshan Fang, Bo Sun, Cong Liu*, Dan Li*, 2020
Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles, Jinge Gu , Zhenying Liu , Shengnan Zhang , Yichen Li , Wencheng Xia , Chen Wang , Huaijiang Xiang , Zhijun Liu , Li Tan , Yanshan Fang , Cong Liu* , Dan Li*, 2020
Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure, Zhao, K., Li, Y., Liu, Z., Long, H., Zhao, C., Luo, F., Sun, Y., Tao, Y., Su, X.-D., Li, D.#, Li, X.#, Liu, C.#, 2020
Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly, Gui, X., Luo, F., Li, YC, Zhou, H., Qin,Z., Liu, ZY, Gu, JG, Xie, MY, Zhao, K., Dai, B., Shin, WS, He, JH, He, L., Jiang, L., Zhao, ML, Sun, B., Li, XM, Liu, C.#, Li, D.#, 2019
Better together: a hybrid amyloid signals necroptosis, Li, D.#, Liu, C.#, 2018

蛋白质稳态分相聚集神经退行性疾病细胞功能蛋白质聚集细胞死亡生物分子组装无膜细胞器病理性聚集帕金森病药物开发早期诊断分子机制细胞机制组织级进展复杂神经系统疾病机制治疗方法

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