Areas of Focus
- 神经退行性疾病中蛋白质稳态调控、分相和聚集
- 帕金森病早期诊断和药物开发
Work Experience
- 2017年至今 - 上海交通大学Bio-X研究院
Academic Background & Achievements
- 1998-2002 学士: 吉林大学生命科学学院
- 2002-2008 博士: 北京大学生命科学学院
- 2008-2014 博士后: 美国加州大学洛杉矶分校
Publications
- Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology, Tao Y.Q., Sun Y.P., Lv S.R., Xia W.C., Zhao K., Xu Q.H., Zhao Q.Y., He L., Wang Y., Liu C.*, Li D.*, 2022
- Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia, Long H.F., Zhang S.N., Zeng S.Y., Tong Y.L., Liu J., Liu C.*, Li D.*, 2022
- Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases, Li D*, Liu C*., 2022
- Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders, Fan Y, Zhao Q, Xia W, Tao Y, Yu W, Chen M, Liu Y, Zhao J, Shen Y, Sun Y, Si C, Zhang S, Zhang Y, Li W, Liu C, Wang J*, Li D*., 2022
- Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease, Dan Li and Cong Liu, 2021
- The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure, Yunpeng Sun#, Kun Zhao#, Wencheng Xia, Jinge Gu, Yeyang Ma, Xinrui Gui, Xia Zhang, Yanshan Fang, Bo Sun, Cong Liu*, Dan Li*, 2020
- Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles, Jinge Gu , Zhenying Liu , Shengnan Zhang , Yichen Li , Wencheng Xia , Chen Wang , Huaijiang Xiang , Zhijun Liu , Li Tan , Yanshan Fang , Cong Liu* , Dan Li*, 2020
- Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure, Zhao, K., Li, Y., Liu, Z., Long, H., Zhao, C., Luo, F., Sun, Y., Tao, Y., Su, X.-D., Li, D.#, Li, X.#, Liu, C.#, 2020
- Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly, Gui, X., Luo, F., Li, YC, Zhou, H., Qin,Z., Liu, ZY, Gu, JG, Xie, MY, Zhao, K., Dai, B., Shin, WS, He, JH, He, L., Jiang, L., Zhao, ML, Sun, B., Li, XM, Liu, C.#, Li, D.#, 2019
- Better together: a hybrid amyloid signals necroptosis, Li, D.#, Liu, C.#, 2018
Awards
- 2018年: 上海市浦江人才计划
- 2019年: 上海高校特聘教授(东方学者)
- 2020年: 中组部万人计划青年拔尖
