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Dan Li
Life Science
Shanghai Jiao Tong University
Shanghai
Language: Chinese, English
Protein Homeostasis
Neurodegenerative Diseases
Protein Aggregation
Cellular Function
Aging
Cell Death
Biomolecular Assembly
Parkinson'S Disease
Drug Development
Early Diagnosis
Areas of Focus
- Protein homeostasis in neurodegenerative diseases
- Early diagnosis and drug development for Parkinson's disease
Work Experience
- 2017-present - Shanghai Jiao Tong University, Bio-X Institutes, Professor
Academic Background & Achievements
- 1998-2002 Bachelor: Jilin University, College of Life Sciences
- 2002-2008 PhD: Peking University, College of Life Sciences
- 2008-2014 Postdoctoral Researcher: University of California, Los Angeles
Publications
- Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology, Li D.*, Liu C.*, 2022
- Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia, Li D.*, Liu C.*, 2022
- Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases, Li D*, Liu C*, 2022
- Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders, Li D*, Liu C*, 2022
- Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease, Dan Li and Cong Liu, 2021
- The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure, Li D.*, Liu C.*, 2020
- Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles, Li D.*, Liu C.*, 2020
- Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure, Li D.#, Liu C.#, 2020
- Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly, Li D.#, Liu C.#, 2019
- Better together: a hybrid amyloid signals necroptosis, Li D.#, Liu C.#, 2018
Awards
- 2018: Shanghai Pujiang Talent Plan
- 2019: Shanghai Universities Specially Appointed Professor (Eastern Scholar)
- 2020: National Ten Thousand Talent Program for Young Top-notch Talent
