Areas of Focus
- Fundamental immunology of lymphocytes
- Molecular mechanisms of immune activation and antibody response
- Regulatory disorders and related diseases
- Mechanical forces in B lymphocytes and their applications in antibody response
- Pathogenic microorganisms and immune evasion mechanisms
Work Experience
- 2005 – 2007 Postdoctoral Researcher - UCSF, Department of Microbiology and Immunology
- 2007 – 2011 Postdoctoral Researcher - NIH, National Institute of Allergy and Infectious Diseases
- 2011 – Present Associate Professor, Professor - Tsinghua University, School of Life Sciences
Academic Background & Achievements
- 1997 – 2001 Bachelor: China Agricultural University, School of Biology
- 2001 – 2005 PhD: Tsinghua University, Department of Biological Sciences and Technology
- Postdoctoral Researcher at UCSF and NIH
Publications
- Ion channel TRPV2 is critical in enhancing B cell activation and function, Wanli Liu et al., 2024
- MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation, Wanli Liu et al., 2024
- An Asian-specific variant in human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment, Wanli Liu et al., 2022
- Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function, Wanli Liu et al., 2019
- Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding, Wanli Liu et al., 2019
- MARCKS regulates tonic and chronic active B cell receptor signaling, Wanli Liu et al., 2019
- An autoimmune disease variant of IgG1 modulates B-cell activation and differentiation, Wanli Liu et al., 2018
- The mevalonate pathway is a druggable target for vaccine adjuvant discovery, Wanli Liu et al., 2018
- PI(4,5)P2 determines the threshold of mechanical force-induced B cell activation, Wanli Liu et al., 2018
- PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies, Wanli Liu et al.
- A PIP2-derived amplification loop fuels the sustained initiation of B cell activation, Wanli Liu et al., 2017
- Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase, Wanli Liu et al., 2017
- Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232, Wanli Liu et al., 2016
- Utilization of a photoactivatable antigen system to examine B cell probing termination and the B cell receptor sorting mechanisms during B cell activation, Wanli Liu et al., 2016
- Acidic phospholipids govern the enhanced activation of IgG-B cell receptor, Wanli Liu et al., 2015
Awards
- 2020: China Youth Science and Technology Award
- 2019: WuXi AppTec Life Science and Chemistry Achievement Award
- 2019: Tan Jiazhen Life Science Innovation Award
- 2018: Newton Advanced Fellowship
- 2017: Shulan Medical Youth Award
