Professor | Wanli Liu | Asia Growth Partners

Name	Wanli Liu
Contact Information	LiuLab@tsinghua.edu.cn
Language ability	English, Chinese
Province	Beijing

Name

Wanli Liu

Contact Information

LiuLab@tsinghua.edu.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Tsinghua University
Faculty	Life Sciences
Academic Background & Achievements	1997 – 2001 Bachelor: China Agricultural University, School of Biology 2001 – 2005 PhD: Tsinghua University, Department of Biological Sciences and Technology Postdoctoral Researcher at UCSF and NIH
Work Experience	2005 – 2007 Postdoctoral Researcher - UCSF, Department of Microbiology and Immunology 2007 – 2011 Postdoctoral Researcher - NIH, National Institute of Allergy and Infectious Diseases 2011 – Present Associate Professor, Professor - Tsinghua University, School of Life Sciences
Awards	2020: China Youth Science and Technology Award 2019: WuXi AppTec Life Science and Chemistry Achievement Award 2019: Tan Jiazhen Life Science Innovation Award 2018: Newton Advanced Fellowship 2017: Shulan Medical Youth Award

University/Lab Affiliation and Title

Tsinghua University

Faculty

Life Sciences

Academic Background & Achievements

1997 – 2001 Bachelor: China Agricultural University, School of Biology
2001 – 2005 PhD: Tsinghua University, Department of Biological Sciences and Technology
Postdoctoral Researcher at UCSF and NIH

Work Experience

2005 – 2007 Postdoctoral Researcher - UCSF, Department of Microbiology and Immunology
2007 – 2011 Postdoctoral Researcher - NIH, National Institute of Allergy and Infectious Diseases
2011 – Present Associate Professor, Professor - Tsinghua University, School of Life Sciences

Awards

2020: China Youth Science and Technology Award
2019: WuXi AppTec Life Science and Chemistry Achievement Award
2019: Tan Jiazhen Life Science Innovation Award
2018: Newton Advanced Fellowship
2017: Shulan Medical Youth Award

Areas of Focus	Fundamental immunology of lymphocytes Molecular mechanisms of immune activation and antibody response Regulatory disorders and related diseases Mechanical forces in B lymphocytes and their applications in antibody response Pathogenic microorganisms and immune evasion mechanisms
Publications	Ion channel TRPV2 is critical in enhancing B cell activation and function, Wanli Liu et al., 2024 MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation, Wanli Liu et al., 2024 An Asian-specific variant in human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment, Wanli Liu et al., 2022 Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function, Wanli Liu et al., 2019 Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding, Wanli Liu et al., 2019 MARCKS regulates tonic and chronic active B cell receptor signaling, Wanli Liu et al., 2019 An autoimmune disease variant of IgG1 modulates B-cell activation and differentiation, Wanli Liu et al., 2018 The mevalonate pathway is a druggable target for vaccine adjuvant discovery, Wanli Liu et al., 2018 PI(4,5)P2 determines the threshold of mechanical force-induced B cell activation, Wanli Liu et al., 2018 PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies, Wanli Liu et al. A PIP2-derived amplification loop fuels the sustained initiation of B cell activation, Wanli Liu et al., 2017 Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase, Wanli Liu et al., 2017 Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232, Wanli Liu et al., 2016 Utilization of a photoactivatable antigen system to examine B cell probing termination and the B cell receptor sorting mechanisms during B cell activation, Wanli Liu et al., 2016 Acidic phospholipids govern the enhanced activation of IgG-B cell receptor, Wanli Liu et al., 2015

Areas of Focus

Fundamental immunology of lymphocytes
Molecular mechanisms of immune activation and antibody response
Regulatory disorders and related diseases
Mechanical forces in B lymphocytes and their applications in antibody response
Pathogenic microorganisms and immune evasion mechanisms

Publications

Ion channel TRPV2 is critical in enhancing B cell activation and function, Wanli Liu et al., 2024
MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation, Wanli Liu et al., 2024
An Asian-specific variant in human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment, Wanli Liu et al., 2022
Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function, Wanli Liu et al., 2019
Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding, Wanli Liu et al., 2019
MARCKS regulates tonic and chronic active B cell receptor signaling, Wanli Liu et al., 2019
An autoimmune disease variant of IgG1 modulates B-cell activation and differentiation, Wanli Liu et al., 2018
The mevalonate pathway is a druggable target for vaccine adjuvant discovery, Wanli Liu et al., 2018
PI(4,5)P2 determines the threshold of mechanical force-induced B cell activation, Wanli Liu et al., 2018
PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies, Wanli Liu et al.
A PIP2-derived amplification loop fuels the sustained initiation of B cell activation, Wanli Liu et al., 2017
Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase, Wanli Liu et al., 2017
Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232, Wanli Liu et al., 2016
Utilization of a photoactivatable antigen system to examine B cell probing termination and the B cell receptor sorting mechanisms during B cell activation, Wanli Liu et al., 2016
Acidic phospholipids govern the enhanced activation of IgG-B cell receptor, Wanli Liu et al., 2015

Lymphocytes Immunology Molecular Mechanisms Immune Activation Antibody Response Regulatory Disorders Diseases Mechanical Forces B Lymphocytes Pathogenic Microorganisms

Wanli Liu - Tsinghua University

Senfang Sui - Tsinghua University

Shun Li - University of Chinese Academy of Sciences

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