Professor | 刘万里 | 数字化转型顾问

Name	刘万里
Contact Information	LiuLab@tsinghua.edu.cn
Language ability	英语, 汉语
Province	北京

Name

刘万里

Contact Information

LiuLab@tsinghua.edu.cn

Language ability

英语, 汉语

Province

北京

University/Lab Affiliation and Title	清华大学
Faculty	Life Sciences
Academic Background & Achievements	1997 – 2001 学士：中国农业大学生物学院 2001 – 2005 博士：清华大学生物科学与技术系在美国加州大学旧金山分校和美国国立卫生研究院进行博士后研究
Work Experience	2005 – 2007 博士后 - 美国加州大学旧金山分校微生物与免疫学系 2007 – 2011 博士后 - 美国国立卫生研究院过敏与传染病研究所 2011 至今副教授、教授 - 清华大学生命科学学院
Awards	2020年：中国青年科技奖 2019年：药明康德生命化学杰出成就奖 2019年：谈家桢生命科学创新奖 2018年：牛顿高级学者奖 2017年：树兰医学青年奖

University/Lab Affiliation and Title

清华大学

Faculty

Life Sciences

Academic Background & Achievements

1997 – 2001 学士：中国农业大学生物学院
2001 – 2005 博士：清华大学生物科学与技术系
在美国加州大学旧金山分校和美国国立卫生研究院进行博士后研究

Work Experience

2005 – 2007 博士后 - 美国加州大学旧金山分校微生物与免疫学系
2007 – 2011 博士后 - 美国国立卫生研究院过敏与传染病研究所
2011 至今副教授、教授 - 清华大学生命科学学院

Awards

2020年：中国青年科技奖
2019年：药明康德生命化学杰出成就奖
2019年：谈家桢生命科学创新奖
2018年：牛顿高级学者奖
2017年：树兰医学青年奖

Areas of Focus	淋巴细胞的基础免疫学免疫活化和抗体应答的分子机制调控紊乱与相关疾病 B淋巴细胞中的机械力及其在抗体应答中的应用病原微生物和免疫逃逸机制
Publications	Ion channel TRPV2 is critical in enhancing B cell activation and function, 刘万里等。, 2024 MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation, 刘万里等。, 2024 An Asian-specific variant in human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment, 刘万里等。, 2022 Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function, 刘万里等。, 2019 Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding, 刘万里等。, 2019 MARCKS regulates tonic and chronic active B cell receptor signaling, 刘万里等。, 2019 An autoimmune disease variant of IgG1 modulates B-cell activation and differentiation, 刘万里等。, 2018 The mevalonate pathway is a druggable target for vaccine adjuvant discovery, 刘万里等。, 2018 PI(4,5)P2 determines the threshold of mechanical force-induced B cell activation, 刘万里等。, 2018 PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies, 刘万里等。, 2018 A PIP2-derived amplification loop fuels the sustained initiation of B cell activation, 刘万里等。, 2017 Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase, 刘万里等。, 2017 Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232, 刘万里等。, 2016 Utilization of a photoactivatable antigen system to examine B cell probing termination and the B cell receptor sorting mechanisms during B cell activation, 刘万里等。, 2016 Acidic phospholipids govern the enhanced activation of IgG-B cell receptor, 刘万里等。, 2015

Areas of Focus

淋巴细胞的基础免疫学
免疫活化和抗体应答的分子机制
调控紊乱与相关疾病
B淋巴细胞中的机械力及其在抗体应答中的应用
病原微生物和免疫逃逸机制

Publications

Ion channel TRPV2 is critical in enhancing B cell activation and function, 刘万里等。, 2024
MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation, 刘万里等。, 2024
An Asian-specific variant in human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment, 刘万里等。, 2022
Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function, 刘万里等。, 2019
Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding, 刘万里等。, 2019
MARCKS regulates tonic and chronic active B cell receptor signaling, 刘万里等。, 2019
An autoimmune disease variant of IgG1 modulates B-cell activation and differentiation, 刘万里等。, 2018
The mevalonate pathway is a druggable target for vaccine adjuvant discovery, 刘万里等。, 2018
PI(4,5)P2 determines the threshold of mechanical force-induced B cell activation, 刘万里等。, 2018
PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies, 刘万里等。, 2018
A PIP2-derived amplification loop fuels the sustained initiation of B cell activation, 刘万里等。, 2017
Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase, 刘万里等。, 2017
Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232, 刘万里等。, 2016
Utilization of a photoactivatable antigen system to examine B cell probing termination and the B cell receptor sorting mechanisms during B cell activation, 刘万里等。, 2016
Acidic phospholipids govern the enhanced activation of IgG-B cell receptor, 刘万里等。, 2015

淋巴细胞免疫学分子机制免疫活化抗体应答调控紊乱疾病机械力 B淋巴细胞病原微生物

杨晓彤 - 上海师范大学

杨晓彤 - 上海师范大学

刘万里 - 清华大学

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