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刘万里
Life Science
清华大学
北京
Language: 英语, 汉语
淋巴细胞
免疫学
B细胞
抗原受体
免疫活化
抗体应答
分子机制
调控紊乱
相关疾病
研究
Areas of Focus
- 淋巴细胞基础免疫学，B细胞抗原受体介导的免疫活化和抗体应答的分子机制，以及此过程调控紊乱与相关疾病发生发展的关系
Work Experience
- 2005 – 2007 博士后 - 美国加州大学旧金山分校微生物与免疫学系
- 2007 – 2011 博士后 - 美国国立卫生研究院过敏与传染病研究所
- 2011.12 – 至今 副教授、教授 - 清华大学生命科学学院
Academic Background & Achievements
- 1997 – 2001 学士: 中国农业大学生物学院
- 2001 – 2005 博士: 清华大学生物科学与技术系
- 在美国加州大学旧金山分校和美国国立卫生研究院进行博士后研究
Publications
- Ion channel TRPV2 is critical in enhancing B cell activation and function, 刘万里等, 2024
- MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation, 刘万里等, 2024
- An Asian-specific variant in human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment, 刘万里等, 2022
- Fc receptor-like 1 intrinsically recruits c-Abl to enhance B cell activation and function, 刘万里等, 2019
- Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding, 刘万里等, 2019
- MARCKS regulates tonic and chronic active B cell receptor signaling, 刘万里等, 2019
- An autoimmune disease variant of IgG1 modulates B-cell activation and differentiation, 刘万里等, 2018
- The mevalonate pathway is a druggable target for vaccine adjuvant discovery, 刘万里等, 2018
- PI(4,5)P2 determines the threshold of mechanical force-induced B cell activation, 刘万里等, 2018
- PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies, 刘万里等, 2018
- A PIP2-derived amplification loop fuels the sustained initiation of B cell activation, 刘万里等, 2017
- Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase, 刘万里等, 2017
- Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232, 刘万里等, 2016
- Utilization of a photoactivatable antigen system to examine B cell probing termination and the B cell receptor sorting mechanisms during B cell activation, 刘万里等, 2016
- Acidic phospholipids govern the enhanced activation of IgG-B cell receptor, 刘万里等, 2015
Awards
- 中国青年科技奖 (2020年)
- 药明康德生命化学杰出成就奖 (2019年)
- 谈家桢生命科学创新奖 (2019年)
- 牛顿高级学者奖 (2018年)
- 树兰医学青年奖 (2017年)
